| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 0 | 1,195,179 | +1,195,179 | 0.00 | 0.19 | +0.19 | buy |
| Point72 Asset Management, L.P. | 593,516 | 990,801 | +397,285 | 0.01 | 0.01 | +0.00 | buy |
| Almitas Capital LLC | 1,026,068 | 1,253,248 | +227,180 | 1.71 | 1.75 | +0.04 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 403,546 | 583,160 | +179,614 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 484,468 | 610,803 | +126,335 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 506,256 | 603,705 | +97,449 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 113,038 | 205,000 | +91,962 | 0.10 | 0.16 | +0.06 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 145,900 | 235,600 | +89,700 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 446,190 | 535,784 | +89,594 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 36,437 | 89,955 | +53,518 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 36,855 | 80,953 | +44,098 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 214,310 | 256,627 | +42,317 | 0.00 | 0.00 | +0.00 | buy |
| CAZ INVESTMENTS LP | 0 | 40,000 | +40,000 | 0.00 | 0.20 | +0.20 | buy |
| BAKER BROS. ADVISORS LP | 1,662,120 | 1,695,294 | +33,174 | 0.08 | 0.07 | -0.01 | buy |
| PDT Partners, LLC | 0 | 27,127 | +27,127 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 27,045 | +27,045 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 24,280 | +24,280 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 683,898 | 707,971 | +24,073 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 21,333 | +21,333 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 20,087 | +20,087 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 46,815 | 63,215 | +16,400 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 16,972 | 33,054 | +16,082 | 0.03 | 0.05 | +0.02 | buy |
| Virtu Financial LLC | 0 | 11,070 | +11,070 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,285,962 | 1,296,788 | +10,826 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 13,384 | 23,497 | +10,113 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 37,500 | 42,090 | +4,590 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 4,311 | 8,244 | +3,933 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,677 | 6,042 | +3,365 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 29,300 | 32,600 | +3,300 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 2,986 | +2,986 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 115,242 | 118,110 | +2,868 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 78,341 | 81,016 | +2,675 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,506 | 13,797 | +2,291 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 11,080 | 12,416 | +1,336 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 1,288 | +1,288 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,329 | 7,234 | +905 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 179,170 | 179,960 | +790 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 52,452 | 53,067 | +615 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 11,560 | 11,855 | +295 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 244 | +244 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 11,495 | 11,632 | +137 | 0.00 | 0.00 | -0.00 | buy |
| Bleakley Financial Group, LLC | 11,495 | 11,632 | +137 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1 | 98 | +97 | 0.00 | 0.00 | 0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 343,000 | 343,000 | 0 | 0.22 | 0.18 | -0.04 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,480,975 | 1,480,975 | 0 | 0.62 | 0.51 | -0.12 | hold |
| Mariner, LLC | 18,674 | 18,674 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Assenagon Asset Management S.A. | 347,794 | 347,794 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Logos Global Management LP | 5,032,501 | 5,032,501 | 0 | 2.13 | 1.94 | -0.19 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 7.22 | 6.85 | -0.38 | hold |
| Corient Private Wealth LLC | 26,965 | 26,965 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,565 | 2,565 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 50,515 | 50,515 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,176 | 1,176 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 28,094 | 28,094 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 32 | 22 | -10 | 0.00 | 0.00 | 0.00 | sell |
| GROUP ONE TRADING LLC | 1,300 | 1,100 | -200 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,748 | 11,083 | -665 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,147 | 10,284 | -863 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,294 | 2,275 | -1,019 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 10,843 | 9,692 | -1,151 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 23,748 | 22,393 | -1,355 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 1,705 | 0 | -1,705 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 698,986 | 695,423 | -3,563 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 5,019 | 1,295 | -3,724 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 404,000 | 400,100 | -3,900 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 48,789 | 44,470 | -4,319 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 25,327 | 19,865 | -5,462 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 10,318 | 4,200 | -6,118 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 216,347 | 209,953 | -6,394 | 0.07 | 0.05 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 7,200 | 0 | -7,200 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 10,474 | 0 | -10,474 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 11,316 | 0 | -11,316 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 12,497 | 0 | -12,497 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,630 | 0 | -12,630 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 14,133 | 0 | -14,133 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,257 | 0 | -15,257 | 0.01 | 0.00 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 48,600 | 32,956 | -15,644 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 16,150 | 0 | -16,150 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 88,908 | 72,033 | -16,875 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 422,035 | 402,715 | -19,320 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 357,284 | 337,345 | -19,939 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 23,395 | 0 | -23,395 | 0.02 | 0.00 | -0.02 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 502,020 | 476,258 | -25,762 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 33,033 | 0 | -33,033 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 38,704 | 0 | -38,704 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 453,400 | 384,075 | -69,325 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 478,092 | 389,437 | -88,655 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 128,305 | 0 | -128,305 | 0.15 | 0.00 | -0.15 | sell |
| Walleye Capital LLC | 194,551 | 60,212 | -134,339 | 0.01 | 0.00 | -0.01 | sell |