| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 913,399 | 1,076,236 | +162,837 | 0.03 | 0.03 | -0.00 | buy |
| Woodline Partners LP | 645,694 | 777,537 | +131,843 | 0.02 | 0.01 | -0.00 | buy |
| Kynam Capital Management, LP | 904,017 | 1,029,579 | +125,562 | 0.30 | 0.37 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,680,975 | 1,780,975 | +100,000 | 0.36 | 0.30 | -0.06 | buy |
| Almitas Capital LLC | 1,452,896 | 1,530,435 | +77,539 | 1.86 | 1.30 | -0.56 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 113,800 | 188,200 | +74,400 | 0.01 | 0.02 | +0.00 | buy |
| VANGUARD GROUP INC | 1,427,467 | 1,471,574 | +44,107 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 42,408 | +42,408 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 31,079 | +31,079 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 84,006 | 109,536 | +25,530 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 288,602 | 313,363 | +24,761 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 775,497 | 794,008 | +18,511 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 12,735 | +12,735 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 21,962 | 28,662 | +6,700 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 14,000 | 20,000 | +6,000 | 0.06 | 0.07 | +0.01 | buy |
| STATE STREET CORP | 714,074 | 719,212 | +5,138 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,069 | 16,314 | +3,245 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 948,050 | 951,198 | +3,148 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 11,331 | 14,364 | +3,033 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 42,090 | 45,030 | +2,940 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 265,000 | 267,800 | +2,800 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 58,278 | 60,555 | +2,277 | 0.08 | 0.06 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 44,415 | 46,385 | +1,970 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 46,369 | 48,317 | +1,948 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 7,902 | 9,698 | +1,796 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 56,405 | 57,925 | +1,520 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,846 | 20,284 | +1,438 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 14,383 | 15,010 | +627 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 2,565 | 3,078 | +513 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 542 | 841 | +299 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,895 | 2,193 | +298 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 15,471 | 15,740 | +269 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 268 | +268 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 31 | 235 | +204 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,357 | 11,402 | +45 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 350 | 350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Logos Global Management LP | 4,217,627 | 4,217,627 | 0 | 2.89 | 1.90 | -1.00 | hold |
| Brooklyn Investment Group | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 1,953,547 | 1,953,547 | 0 | 0.34 | 0.26 | -0.08 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 6.47 | 4.77 | -1.70 | hold |
| Lynx1 Capital Management LP | 65,954 | 65,954 | 0 | 0.09 | 0.06 | -0.03 | hold |
| Corient Private Wealth LLC | 26,965 | 26,965 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 6,598 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 1,449 | 1,449 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 22,600 | 22,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,176 | 1,176 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 28,129 | 28,094 | -35 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 74 | 0 | -74 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 11,916 | 11,824 | -92 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 3,940 | 3,759 | -181 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 228 | 0 | -228 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 263 | 0 | -263 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,165 | 1,817 | -348 | 0.00 | 0.00 | -0.00 | sell |
| COLDSTREAM CAPITAL MANAGEMENT INC | 535 | 0 | -535 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 95,348 | 94,603 | -745 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,737 | 17,957 | -780 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 20,550 | 19,668 | -882 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 19,277 | 18,325 | -952 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,957 | 11,955 | -1,002 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,275 | 0 | -2,275 | 0.00 | 0.00 | -0.00 | sell |
| CoreCap Advisors, LLC | 2,879 | 0 | -2,879 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 31,740 | 28,726 | -3,014 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 630,953 | 627,348 | -3,605 | 0.01 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 17,482 | 13,501 | -3,981 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 395,251 | 390,648 | -4,603 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 36,917 | 31,125 | -5,792 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 258,375 | 250,949 | -7,426 | 0.00 | 0.00 | -0.00 | sell |
| CAZ INVESTMENTS LP | 15,000 | 7,500 | -7,500 | 0.42 | 0.14 | -0.27 | sell |
| MPM BioImpact LLC | 562,943 | 555,187 | -7,756 | 0.37 | 0.32 | -0.05 | sell |
| CITIGROUP INC | 22,879 | 13,648 | -9,231 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,251 | 0 | -9,251 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 1,817,858 | 1,807,218 | -10,640 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 373,653 | 362,518 | -11,135 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 72,149 | 59,975 | -12,174 | 0.03 | 0.01 | -0.01 | sell |
| SG Americas Securities, LLC | 12,980 | 0 | -12,980 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 147,228 | 133,028 | -14,200 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 15,383 | 0 | -15,383 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 18,962 | 0 | -18,962 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 266,016 | 239,459 | -26,557 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 1,743,725 | 1,712,882 | -30,843 | 0.07 | 0.06 | -0.02 | sell |
| TWO SIGMA ADVISERS, LP | 146,700 | 108,500 | -38,200 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 128,747 | 89,311 | -39,436 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 52,872 | 3,823 | -49,049 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 2,479,963 | 2,395,743 | -84,220 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 87,988 | 0 | -87,988 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 963,460 | 840,793 | -122,667 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 141,519 | 0 | -141,519 | 0.00 | 0.00 | -0.00 | sell |