| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 7.59 | 9.09 | +1.50 | hold |
| Logos Global Management LP | 1,950,000 | 3,000,000 | +1,050,000 | 1.07 | 1.87 | +0.80 | buy |
| BAKER BROS. ADVISORS LP | 2,585,978 | 2,678,430 | +92,452 | 0.16 | 0.19 | +0.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,744,987 | 2,661,115 | +916,128 | 0.14 | 0.22 | +0.09 | buy |
| BlackRock, Inc. | 2,133,764 | 2,660,024 | +526,260 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,722,754 | 2,366,453 | -356,301 | 0.05 | 0.05 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 0 | 1,809,854 | +1,809,854 | 0.00 | 0.57 | +0.57 | buy |
| Vivo Capital, LLC | 1,612,903 | 1,612,903 | 0 | 1.43 | 2.13 | +0.70 | hold |
| Caption Management, LLC | 86,708 | 1,118,098 | +1,031,390 | 0.04 | 0.57 | +0.53 | buy |
| Almitas Capital LLC | 1,530,335 | 1,026,893 | -503,442 | 3.68 | 3.56 | -0.12 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 692,518 | 958,417 | +265,899 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 865,135 | +865,135 | 0.00 | 0.67 | +0.67 | buy |
| FMR LLC | 798,411 | 776,462 | -21,949 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 656,565 | 765,425 | +108,860 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 659,575 | 736,221 | +76,646 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 961,501 | 700,354 | -261,147 | 0.04 | 0.03 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 431,840 | 694,743 | +262,903 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 504,718 | 656,584 | +151,866 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 289,385 | 565,597 | +276,212 | 0.01 | 0.03 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 616,481 | 537,479 | -79,002 | 0.01 | 0.01 | -0.00 | sell |
| Siren, L.L.C. | 0 | 523,212 | +523,212 | 0.00 | 0.15 | +0.15 | buy |
| Qube Research & Technologies Ltd | 34,183 | 437,079 | +402,896 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 408,200 | 387,913 | -20,287 | 0.01 | 0.01 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 271,554 | 384,036 | +112,482 | 0.06 | 0.10 | +0.04 | buy |
| NORTHERN TRUST CORP | 300,279 | 353,197 | +52,918 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 204,739 | 296,085 | +91,346 | 0.03 | 0.05 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 145,900 | 282,564 | +136,664 | 1.10 | 2.85 | +1.75 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 271,264 | +271,264 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 241,485 | 271,264 | +29,779 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 45,810 | 224,170 | +178,360 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 470,270 | 195,645 | -274,625 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 0 | 190,000 | +190,000 | 0.00 | 0.15 | +0.15 | buy |
| J. Goldman & Co LP | 0 | 176,770 | +176,770 | 0.00 | 0.09 | +0.09 | buy |
| MILLENNIUM MANAGEMENT LLC | 108,928 | 147,714 | +38,786 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 108,449 | 138,521 | +30,072 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 111,103 | +111,103 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 126,815 | 104,734 | -22,081 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 0 | 102,600 | +102,600 | 0.00 | 0.28 | +0.28 | buy |
| Bank of New York Mellon Corp | 79,645 | 92,069 | +12,424 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 35,109 | 89,940 | +54,831 | 0.03 | 0.08 | +0.05 | buy |
| CITADEL ADVISORS LLC | 231,513 | 81,971 | -149,542 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 80,663 | +80,663 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 65,638 | 76,825 | +11,187 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 71,408 | 71,744 | +336 | 0.19 | 0.22 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 25,957 | 71,114 | +45,157 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 34,990 | 67,598 | +32,608 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 50,209 | 63,391 | +13,182 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 25,437 | 63,100 | +37,663 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 49,214 | 59,249 | +10,035 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 44,700 | 50,500 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 43,728 | +43,728 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 46,120 | 43,230 | -2,890 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 41,286 | +41,286 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 34,860 | 38,132 | +3,272 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 33,375 | +33,375 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,300 | 32,925 | +16,625 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 60,400 | 32,600 | -27,800 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 0 | 32,087 | +32,087 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 20,644 | 30,613 | +9,969 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 29,827 | +29,827 | 0.00 | 0.10 | +0.10 | buy |
| Squarepoint Ops LLC | 86,117 | 29,630 | -56,487 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 117,111 | 28,150 | -88,961 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 9,027 | 28,072 | +19,045 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 27,169 | 27,169 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 52,000 | 27,000 | -25,000 | 0.01 | 0.01 | -0.00 | sell |
| Quantinno Capital Management LP | 14,128 | 26,901 | +12,773 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,370 | 25,606 | +9,236 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 133,203 | 22,740 | -110,463 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 60,939 | 22,383 | -38,556 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 141,920 | 21,429 | -120,491 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,193 | 20,700 | +5,507 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 15,249 | 20,609 | +5,360 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 19,400 | +19,400 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 14,134 | 16,904 | +2,770 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,263 | 15,880 | +11,617 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 15,844 | +15,844 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 14,824 | 14,824 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,363 | 14,171 | +2,808 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,910 | +12,910 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 12,553 | +12,553 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 11,366 | 12,254 | +888 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 55,790 | 11,707 | -44,083 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 10,826 | +8,800 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,328 | +10,328 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 9,849 | +3,251 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 50,272 | 5,751 | -44,521 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 610 | 5,610 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,545 | 4,908 | +3,363 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 4,064 | +4,064 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 3,684 | 3,684 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAZ INVESTMENTS LP | 3,500 | 3,500 | 0 | 0.04 | 0.02 | -0.02 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,594 | 3,025 | +1,431 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,077 | 2,987 | +910 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,793 | +223 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,971 | 2,793 | -178 | 0.00 | 0.00 | -0.00 | sell |
| State of Wyoming | 0 | 2,566 | +2,566 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,816 | 1,816 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAMMA Investing LLC | 1,472 | 1,450 | -22 | 0.00 | 0.00 | +0.00 | sell |
| Caitong International Asset Management Co., Ltd | 1 | 1,259 | +1,258 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,271 | 1,209 | -62 | 0.00 | 0.00 | -0.00 | sell |