| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 81,016 | 828,665 | +747,649 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,195,179 | 1,892,547 | +697,368 | 0.19 | 0.41 | +0.22 | buy |
| Point72 Asset Management, L.P. | 990,801 | 1,600,740 | +609,939 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 304,630 | 575,550 | +270,920 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,296,788 | 1,394,024 | +97,236 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 179,960 | 257,432 | +77,472 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 1,253,248 | 1,323,667 | +70,419 | 1.75 | 2.52 | +0.77 | buy |
| EcoR1 Capital, LLC | 0 | 53,834 | +53,834 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 80,953 | 134,360 | +53,407 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 707,971 | 758,550 | +50,579 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,695,294 | 1,743,725 | +48,431 | 0.07 | 0.10 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 535,784 | 582,858 | +47,074 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 40,687 | +40,687 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 389,437 | 428,798 | +39,361 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 11,070 | 46,356 | +35,286 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 72,033 | 96,635 | +24,602 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 19,334 | +19,334 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,234 | 23,145 | +15,911 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 13,221 | +13,221 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 12,289 | +12,289 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 11,902 | +11,902 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,333 | 32,634 | +11,301 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 60,212 | 70,000 | +9,788 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 27,127 | 36,099 | +8,972 | 0.01 | 0.02 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 1,295 | 7,602 | +6,307 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 33,054 | 36,774 | +3,720 | 0.05 | 0.08 | +0.03 | buy |
| ALGERT GLOBAL LLC | 12,416 | 14,378 | +1,962 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 17,197 | +927 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 13,797 | 14,415 | +618 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 417 | +417 | 0.00 | 0.00 | +0.00 | buy |
| Newbridge Financial Services Group, Inc. | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 143 | +143 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 11,855 | 11,905 | +50 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 98 | 124 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,275 | 2,275 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 235,600 | 235,600 | 0 | 0.02 | 0.03 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 42,090 | 42,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 343,000 | 343,000 | 0 | 0.18 | 0.27 | +0.09 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,480,975 | 1,480,975 | 0 | 0.51 | 0.57 | +0.06 | hold |
| PRINCIPAL SECURITIES, INC. | 74 | 74 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 244 | 244 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 6.85 | 7.04 | +0.20 | hold |
| Corient Private Wealth LLC | 26,965 | 26,965 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,565 | 2,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,284 | 10,284 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 32,600 | 32,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 583,160 | 583,160 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMALGAMATED BANK | 1,176 | 1,176 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 28,094 | 28,094 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 22 | 20 | -2 | 0.00 | 0.00 | 0.00 | sell |
| Bleakley Financial Group, LLC | 11,632 | 11,591 | -41 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 1,100 | 1,000 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 16,892 | 16,789 | -103 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,083 | 10,784 | -299 | 0.00 | 0.00 | +0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,692 | 9,219 | -473 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 337,345 | 336,774 | -571 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 19,865 | 18,738 | -1,127 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 4,200 | 2,988 | -1,212 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 1,288 | 0 | -1,288 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 347,794 | 346,192 | -1,602 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 53,067 | 50,567 | -2,500 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 18,674 | 16,128 | -2,546 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 2,986 | 0 | -2,986 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 8,244 | 4,492 | -3,752 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 63,215 | 59,115 | -4,100 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,042 | 1,705 | -4,337 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 695,423 | 690,826 | -4,597 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 89,955 | 85,131 | -4,824 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 24,280 | 17,192 | -7,088 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 50,515 | 43,245 | -7,270 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 20,087 | 11,000 | -9,087 | 0.00 | 0.00 | -0.00 | sell |
| Simplicity Wealth,LLC | 11,632 | 0 | -11,632 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 44,470 | 31,287 | -13,183 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 22,393 | 8,272 | -14,121 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 32,956 | 15,985 | -16,971 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 118,110 | 99,125 | -18,985 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 23,497 | 0 | -23,497 | 0.00 | 0.00 | -0.00 | sell |
| CAZ INVESTMENTS LP | 40,000 | 15,000 | -25,000 | 0.20 | 0.08 | -0.12 | sell |
| Verition Fund Management LLC | 27,045 | 0 | -27,045 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 209,953 | 173,744 | -36,209 | 0.05 | 0.07 | +0.02 | sell |
| TWO SIGMA ADVISERS, LP | 400,100 | 304,900 | -95,200 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 402,715 | 304,244 | -98,471 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 384,075 | 274,000 | -110,075 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 476,258 | 280,271 | -195,987 | 0.01 | 0.01 | -0.00 | sell |
| Opaleye Management Inc. | 205,000 | 0 | -205,000 | 0.16 | 0.00 | -0.16 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 256,627 | 0 | -256,627 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 603,705 | 275,532 | -328,173 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 610,803 | 207,257 | -403,546 | 0.00 | 0.00 | -0.00 | sell |
| BML Capital Management, LLC | 421,749 | 0 | -421,749 | 1.03 | 0.00 | -1.03 | sell |
| Logos Global Management LP | 5,032,501 | 4,217,627 | -814,874 | 1.94 | 2.54 | +0.60 | sell |