| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 1,807,218 | 3,340,552 | +1,533,334 | 0.01 | 0.05 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 475,699 | +475,699 | 0.00 | 0.04 | +0.04 | buy |
| JANE STREET GROUP, LLC | 31,079 | 117,833 | +86,754 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 68,823 | +68,823 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| HRT FINANCIAL LP | 0 | 31,903 | +31,903 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,402 | 34,982 | +23,580 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 239,459 | 261,445 | +21,986 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 21,918 | +21,918 | 0.00 | 0.04 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 15,010 | 29,411 | +14,401 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 11,868 | +11,868 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 10,320 | +10,320 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 267,800 | 274,300 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 5,702 | +5,702 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 18,325 | 23,221 | +4,896 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 46,385 | 50,852 | +4,467 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 3,759 | 6,377 | +2,618 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,969 | +1,969 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,823 | 5,133 | +1,310 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 45,030 | 46,120 | +1,090 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 841 | 1,648 | +807 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 443 | +443 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 19 | 385 | +366 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 15,740 | 16,081 | +341 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 328 | +328 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 14,364 | 14,589 | +225 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 222 | +222 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 194 | +194 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 71 | +71 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,193 | 2,202 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 188,200 | 188,200 | 0 | 0.02 | 0.03 | +0.02 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,780,975 | 1,780,975 | 0 | 0.30 | 0.52 | +0.21 | hold |
| BAKER BROS. ADVISORS LP | 1,712,882 | 1,712,882 | 0 | 0.06 | 0.09 | +0.04 | hold |
| Almitas Capital LLC | 1,530,435 | 1,530,435 | 0 | 1.30 | 2.64 | +1.34 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MPM BioImpact LLC | 555,187 | 555,187 | 0 | 0.32 | 0.68 | +0.36 | hold |
| EverSource Wealth Advisors, LLC | 235 | 235 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 268 | 268 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rise Advisors, LLC | 130 | 130 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 20,000 | 20,000 | 0 | 0.07 | 0.14 | +0.07 | hold |
| Nuveen, LLC | 133,028 | 133,028 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 1,953,547 | 1,953,547 | 0 | 0.26 | 0.44 | +0.18 | hold |
| Kynam Capital Management, LP | 1,029,579 | 1,029,579 | 0 | 0.37 | 0.58 | +0.20 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 4.77 | 7.11 | +2.34 | hold |
| Lynx1 Capital Management LP | 65,954 | 65,954 | 0 | 0.06 | 0.10 | +0.04 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 6,598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,314 | 16,314 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 22,600 | 22,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,176 | 1,176 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 11,824 | 11,824 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,076,236 | 1,076,236 | 0 | 0.03 | 0.06 | +0.03 | hold |
| Brooklyn Investment Group | 19 | 0 | -19 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,449 | 1,213 | -236 | 0.00 | 0.00 | +0.00 | sell |
| Daiwa Securities Group Inc. | 350 | 100 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,817 | 1,227 | -590 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 3,078 | 2,077 | -1,001 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 28,662 | 27,062 | -1,600 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 20,284 | 18,317 | -1,967 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 48,317 | 46,334 | -1,983 | 0.00 | 0.00 | +0.00 | sell |
| CAZ INVESTMENTS LP | 7,500 | 5,000 | -2,500 | 0.14 | 0.07 | -0.07 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,949 | 247,934 | -3,015 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 19,668 | 14,155 | -5,513 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 94,603 | 87,475 | -7,128 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,957 | 10,724 | -7,233 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 9,698 | 1,959 | -7,739 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 60,555 | 52,081 | -8,474 | 0.06 | 0.13 | +0.06 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 627,348 | 617,489 | -9,859 | 0.00 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,955 | 0 | -11,955 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 13,648 | 1,590 | -12,058 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 12,735 | 0 | -12,735 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 57,925 | 44,825 | -13,100 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 13,501 | 0 | -13,501 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 28,726 | 13,664 | -15,062 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 390,648 | 373,276 | -17,372 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 109,536 | 88,176 | -21,360 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 26,965 | 0 | -26,965 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,471,574 | 1,443,701 | -27,873 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 28,094 | 0 | -28,094 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 89,311 | 59,237 | -30,074 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 31,125 | 0 | -31,125 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 313,363 | 279,817 | -33,546 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 42,408 | 0 | -42,408 | 0.02 | 0.00 | -0.02 | sell |
| GSA CAPITAL PARTNERS LLP | 59,975 | 0 | -59,975 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 362,518 | 296,529 | -65,989 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 108,500 | 40,500 | -68,000 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 719,212 | 634,397 | -84,815 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 794,008 | 695,613 | -98,395 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 777,537 | 612,712 | -164,825 | 0.01 | 0.02 | +0.01 | sell |
| FMR LLC | 951,198 | 740,849 | -210,349 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 840,793 | 554,020 | -286,773 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 2,395,743 | 2,044,388 | -351,355 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 4,217,627 | 3,655,000 | -562,627 | 1.90 | 2.72 | +0.82 | sell |