| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 776,082 | +776,082 | 0.00 | 0.04 | +0.04 | buy |
| MPM BioImpact LLC | 0 | 559,547 | +559,547 | 0.00 | 0.49 | +0.49 | buy |
| CITADEL ADVISORS LLC | 575,550 | 958,793 | +383,243 | 0.00 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 53,834 | 426,683 | +372,849 | 0.01 | 0.11 | +0.10 | buy |
| Point72 Asset Management, L.P. | 1,600,740 | 1,856,750 | +256,010 | 0.03 | 0.03 | +0.00 | buy |
| BlackRock, Inc. | 2,358,797 | 2,579,599 | +220,802 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 828,665 | 951,882 | +123,217 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 134,360 | 215,265 | +80,905 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 70,000 | 141,127 | +71,127 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 0 | 66,587 | +66,587 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 1,892,547 | 1,953,547 | +61,000 | 0.41 | 0.50 | +0.09 | buy |
| NORTHERN TRUST CORP | 336,774 | 388,125 | +51,351 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 40,687 | 89,215 | +48,528 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 48,424 | +48,424 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 40,289 | +40,289 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,394,024 | 1,430,745 | +36,721 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 690,826 | 723,319 | +32,493 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 275,532 | 297,129 | +21,597 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 10,784 | 29,855 | +19,071 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 36,774 | 54,696 | +17,922 | 0.08 | 0.13 | +0.05 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 17,665 | +17,665 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 14,266 | +14,266 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 12,006 | +12,006 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 11,583 | +11,583 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,525 | +11,525 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257,432 | 264,675 | +7,243 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 96,635 | 103,571 | +6,936 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 32,634 | 39,115 | +6,481 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,415 | 18,428 | +4,013 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 758,550 | 761,640 | +3,090 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 50,567 | 52,932 | +2,365 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,284 | 12,451 | +2,167 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,887 | +1,887 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 14,378 | 16,238 | +1,860 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 11,591 | 13,266 | +1,675 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 12,289 | 13,667 | +1,378 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,145 | 24,476 | +1,331 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 102 | 1,005 | +903 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,197 | 17,957 | +760 | 0.00 | 0.00 | +0.00 | buy |
| Venturi Wealth Management, LLC | 0 | 753 | +753 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 712 | +712 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 417 | 1,070 | +653 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 16,128 | 16,257 | +129 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,705 | 1,761 | +56 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 124 | 141 | +17 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,275 | 2,275 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 42,090 | 42,090 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAZ INVESTMENTS LP | 15,000 | 15,000 | 0 | 0.08 | 0.13 | +0.06 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,480,975 | 1,480,975 | 0 | 0.57 | 0.60 | +0.04 | hold |
| PRINCIPAL SECURITIES, INC. | 74 | 74 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,743,725 | 1,743,725 | 0 | 0.10 | 0.11 | +0.02 | hold |
| MetLife Investment Management, LLC | 19,334 | 19,334 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDT Partners, LLC | 36,099 | 36,099 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Almitas Capital LLC | 1,323,667 | 1,323,667 | 0 | 2.52 | 1.79 | -0.72 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Logos Global Management LP | 4,217,627 | 4,217,627 | 0 | 2.54 | 3.04 | +0.50 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 7.04 | 9.82 | +2.78 | hold |
| Corient Private Wealth LLC | 26,965 | 26,965 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 19 | 19 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 9,219 | 9,219 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 2,565 | 2,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 32,600 | 32,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,176 | 1,176 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 28,094 | 28,094 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 20 | 0 | -20 | 0.00 | 0.00 | 0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 11,905 | 11,855 | -50 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 67 | 0 | -67 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 244 | 143 | -101 | 0.00 | 0.00 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 143 | 0 | -143 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,221 | 13,070 | -151 | 0.00 | 0.00 | +0.00 | sell |
| Newbridge Financial Services Group, Inc. | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 16,789 | 15,610 | -1,179 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 4,492 | 3,059 | -1,433 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 7,602 | 5,168 | -2,434 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 59,115 | 56,315 | -2,800 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 2,988 | 0 | -2,988 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 99,125 | 95,348 | -3,777 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 8,272 | 0 | -8,272 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 11,000 | 0 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| Paloma Partners Management Co | 11,902 | 0 | -11,902 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 583,160 | 567,604 | -15,556 | 0.01 | 0.01 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,985 | 0 | -15,985 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 17,192 | 0 | -17,192 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 18,738 | 0 | -18,738 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 274,000 | 253,500 | -20,500 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 31,287 | 0 | -31,287 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 85,131 | 48,186 | -36,945 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 43,245 | 0 | -43,245 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 46,356 | 0 | -46,356 | 0.01 | 0.00 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 173,744 | 118,328 | -55,416 | 0.07 | 0.05 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 582,858 | 512,330 | -70,528 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 304,900 | 233,900 | -71,000 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 428,798 | 346,183 | -82,615 | 0.00 | 0.00 | -0.00 | sell |