| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 3,340,552 | 5,372,004 | +2,031,452 | 0.05 | 0.08 | +0.02 | buy |
| Vivo Capital, LLC | 0 | 1,612,903 | +1,612,903 | 0.00 | 0.98 | +0.98 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 475,699 | 1,461,381 | +985,682 | 0.04 | 0.14 | +0.10 | buy |
| MORGAN STANLEY | 0 | 702,306 | +702,306 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,712,882 | 2,233,099 | +520,217 | 0.09 | 0.12 | +0.03 | buy |
| Woodline Partners LP | 612,712 | 944,039 | +331,327 | 0.02 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 14,589 | 305,757 | +291,168 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 225,528 | +225,528 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 194,611 | +194,611 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 187,769 | +187,769 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 1,443,701 | 1,630,910 | +187,209 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 158,383 | +158,383 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 150,906 | +150,906 | 0.00 | 0.96 | +0.96 | buy |
| MILLENNIUM MANAGEMENT LLC | 68,823 | 180,866 | +112,043 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 109,763 | +109,763 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 117,833 | 226,512 | +108,679 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,076,236 | 1,179,817 | +103,581 | 0.06 | 0.08 | +0.02 | buy |
| DIADEMA PARTNERS LP | 0 | 100,320 | +100,320 | 0.00 | 0.56 | +0.56 | buy |
| Trexquant Investment LP | 0 | 99,967 | +99,967 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,133 | 94,828 | +89,695 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 78,949 | +78,949 | 0.00 | 0.08 | +0.08 | buy |
| BlackRock, Inc. | 2,044,388 | 2,117,156 | +72,768 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 373,276 | 438,894 | +65,618 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 61,852 | +61,852 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 54,600 | +54,600 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 52,730 | +52,730 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 46,771 | +46,771 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 46,142 | +46,142 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 34,989 | +34,989 | 0.00 | 0.16 | +0.16 | buy |
| FMR LLC | 740,849 | 771,268 | +30,419 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 26,965 | +26,965 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,062 | 50,657 | +23,595 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,868 | 35,284 | +23,416 | 0.00 | 0.01 | +0.00 | buy |
| Virtu Financial LLC | 0 | 22,651 | +22,651 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 29,411 | 50,023 | +20,612 | 0.00 | 0.01 | +0.01 | buy |
| Baader Bank Aktiengesellschaft | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 6,377 | 25,234 | +18,857 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 279,817 | 297,921 | +18,104 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 52,081 | 69,377 | +17,296 | 0.13 | 0.16 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 0 | 15,541 | +15,541 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 14,012 | +14,012 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 634,397 | 647,636 | +13,239 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 274,300 | 287,100 | +12,800 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 11,728 | +11,728 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,396 | +11,396 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 261,445 | 270,654 | +9,209 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,317 | 26,786 | +8,469 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 7,093 | +7,093 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 50,852 | 57,798 | +6,946 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,320 | 15,249 | +4,929 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 65,954 | 69,516 | +3,562 | 0.10 | 0.13 | +0.03 | buy |
| STRS OHIO | 22,600 | 25,200 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,959 | 4,273 | +2,314 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 1,816 | +1,816 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,590 | 3,113 | +1,523 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 738 | +738 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,202 | 2,768 | +566 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 380 | +380 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,724 | 11,091 | +367 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 443 | 750 | +307 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 13,664 | 13,730 | +66 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,570 | 2,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 239 | 239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 46,120 | 46,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,227 | 1,227 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Almitas Capital LLC | 1,530,435 | 1,530,435 | 0 | 2.64 | 3.16 | +0.52 | hold |
| Capital Advisors, Ltd. LLC | 12 | 12 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Larson Financial Group LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 268 | 268 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 20,000 | 20,000 | 0 | 0.14 | 0.11 | -0.03 | hold |
| Optiver Holding B.V. | 328 | 328 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 6,526,476 | 6,526,476 | 0 | 7.11 | 8.67 | +1.56 | hold |
| Farther Finance Advisors, LLC | 385 | 385 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 558 | 558 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,598 | 6,598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 2,077 | 2,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,026 | 2,026 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearstead Advisors, LLC | 610 | 610 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 11,824 | 11,824 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 71 | 0 | -71 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,213 | 1,118 | -95 | 0.00 | 0.00 | +0.00 | sell |
| Rise Advisors, LLC | 130 | 0 | -130 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 194 | 47 | -147 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 222 | 0 | -222 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 235 | 3 | -232 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 1,648 | 1,377 | -271 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 1,176 | 751 | -425 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,969 | 1,471 | -498 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,314 | 15,711 | -603 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 34,982 | 34,282 | -700 | 0.02 | 0.02 | +0.00 | sell |
| BARCLAYS PLC | 88,176 | 87,060 | -1,116 | 0.00 | 0.00 | +0.00 | sell |
| CAZ INVESTMENTS LP | 5,000 | 3,500 | -1,500 | 0.07 | 0.06 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 44,825 | 42,710 | -2,115 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 87,475 | 84,975 | -2,500 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 16,081 | 12,822 | -3,259 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 617,489 | 612,768 | -4,721 | 0.01 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 133,028 | 125,260 | -7,768 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 23,221 | 14,451 | -8,770 | 0.00 | 0.00 | -0.00 | sell |