| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,691,290 | 8,829,053 | +7,137,763 | 0.48 | 2.91 | +2.43 | buy |
| JANUS HENDERSON GROUP PLC | 900,816 | 876,523 | -24,293 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 841,395 | 841,395 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Nantahala Capital Management, LLC | 841,395 | 838,095 | -3,300 | 0.59 | 0.65 | +0.06 | sell |
| FRANKLIN RESOURCES INC | 796,644 | 796,644 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AWM Investment Company, Inc. | 0 | 625,000 | +625,000 | 0.00 | 0.70 | +0.70 | buy |
| Schonfeld Strategic Advisors LLC | 260,417 | 272,817 | +12,400 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 215,070 | 213,067 | -2,003 | 0.00 | 0.00 | +0.00 | sell |
| Simplify Asset Management Inc. | 51,216 | 116,535 | +65,319 | 0.03 | 0.07 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 63,975 | 83,987 | +20,012 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.01 | +0.01 | buy |
| Lion Point Capital, LP | 0 | 39,000 | +39,000 | 0.00 | 1.44 | +1.44 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 29,800 | +29,800 | 0.00 | 0.22 | +0.22 | buy |
| NORTHERN TRUST CORP | 24,924 | 24,775 | -149 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 14,879 | +14,879 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 14,244 | +14,244 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 5,438 | 6,540 | +1,102 | 0.01 | 0.01 | +0.00 | buy |
| NewEdge Advisors, LLC | 0 | 610 | +610 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 186 | 186 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 89 | 89 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 891 | 0 | -891 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |