| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 1,484,911 | 10,000,000 | +8,515,089 | 0.24 | 1.55 | +1.31 | buy |
| T. Rowe Price Investment Management, Inc. | 2,824,169 | 6,304,672 | +3,480,503 | 0.02 | 0.04 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 3,491,500 | 4,582,409 | +1,090,909 | 0.82 | 0.84 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,334,169 | 3,225,360 | +891,191 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,136,339 | 2,818,908 | +682,569 | 1.05 | 1.04 | -0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,838,853 | 6,443,398 | +604,545 | 0.70 | 0.85 | +0.15 | buy |
| Woodline Partners LP | 2,070,083 | 2,373,987 | +303,904 | 0.24 | 0.23 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 1,543,407 | 1,769,708 | +226,301 | 0.33 | 0.34 | +0.02 | buy |
| Zimmer Partners, LP | 210,000 | 397,000 | +187,000 | 0.08 | 0.09 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 350,000 | +150,000 | 0.38 | 0.46 | +0.07 | buy |
| TD ASSET MANAGEMENT INC | 227,118 | 319,756 | +92,638 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 704,391 | 637,954 | +66,437 | 0.00 | 0.00 | 0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 621,111 | 666,111 | +45,000 | 1.05 | 0.98 | -0.07 | buy |
| DAFNA Capital Management LLC | 105,000 | 145,000 | +40,000 | 0.26 | 0.35 | +0.08 | buy |
| Ikarian Capital, LLC | 49,031 | 49,415 | +384 | 0.05 | 0.06 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 9,447 | 8,837 | -610 | 0.06 | 0.05 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 22,000 | 16,200 | -5,800 | 0.10 | 0.05 | -0.06 | sell |
| ARISTEIA CAPITAL, L.L.C. | 857,758 | 839,058 | -18,700 | 0.10 | 0.09 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 313,574 | 288,689 | -24,885 | 0.13 | 0.12 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621,500 | 481,252 | -140,248 | 0.01 | 0.01 | -0.00 | sell |
| 683 Capital Management, LLC | 1,100,000 | 900,000 | -200,000 | 0.95 | 0.69 | -0.26 | sell |
| Hudson Bay Capital Management LP | 475,580 | 225,023 | -250,557 | 0.03 | 0.01 | -0.02 | sell |
| STEMPOINT CAPITAL LP | 1,020,214 | 491,926 | -528,288 | 2.89 | 1.38 | -1.51 | sell |
| Nantahala Capital Management, LLC | 1,413,956 | 787,974 | -625,982 | 0.89 | 0.47 | -0.42 | sell |
| Sofinnova Investments, Inc. | 2,969,039 | 2,163,646 | -805,393 | 1.75 | 1.27 | -0.48 | sell |
| Vestal Point Capital, LP | 2,100,000 | 1,200,000 | -900,000 | 2.34 | 1.04 | -1.30 | sell |
| Rock Springs Capital Management LP | 1,875,466 | 848,751 | -1,026,715 | 0.49 | 0.23 | -0.26 | sell |