| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 1,484,911 | 10,000,000 | +8,515,089 | 0.24 | 1.55 | +1.31 | buy |
| T. Rowe Price Investment Management, Inc. | 2,824,169 | 6,304,672 | +3,480,503 | 0.02 | 0.04 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,352,929 | 8,326,332 | +1,973,403 | 0.01 | 0.02 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,750,000 | +1,750,000 | 0.00 | 0.23 | +0.23 | buy |
| VR Adviser, LLC | 0 | 1,750,000 | +1,750,000 | 0.00 | 0.87 | +0.87 | buy |
| PERCEPTIVE ADVISORS LLC | 3,491,500 | 4,582,409 | +1,090,909 | 0.82 | 0.85 | +0.03 | buy |
| Logos Global Management LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 1.11 | +1.11 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 946,563 | +946,563 | 0.00 | 0.42 | +0.42 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,334,169 | 3,225,360 | +891,191 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 0 | 730,394 | +730,394 | 0.00 | 0.04 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 2,136,339 | 2,818,908 | +682,569 | 1.05 | 1.04 | -0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,838,853 | 6,443,398 | +604,545 | 0.70 | 0.85 | +0.15 | buy |
| MORGAN STANLEY | 153,293 | 512,897 | +359,604 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 2,070,083 | 2,373,987 | +303,904 | 0.24 | 0.23 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,548,909 | 1,809,269 | +260,360 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,543,407 | 1,769,708 | +226,301 | 0.33 | 0.34 | +0.02 | buy |
| Qube Research & Technologies Ltd | 2,448 | 224,908 | +222,460 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 210,000 | 397,000 | +187,000 | 0.08 | 0.09 | +0.01 | buy |
| Walleye Capital LLC | 485,710 | 660,179 | +174,469 | 0.07 | 0.08 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 350,000 | +150,000 | 0.42 | 0.60 | +0.18 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 137,739 | +137,739 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 122,036 | +122,036 | 0.00 | 0.12 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 227,118 | 319,756 | +92,638 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,219 | 132,415 | +64,196 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 62,632 | +62,632 | 0.00 | 0.03 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 621,111 | 666,111 | +45,000 | 1.21 | 1.13 | -0.08 | buy |
| DAFNA Capital Management LLC | 105,000 | 145,000 | +40,000 | 0.26 | 0.35 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 30,243 | +30,243 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 25,433 | +25,433 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 24,437 | +24,437 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 23,832 | +23,832 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 137,800 | 157,500 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 19,043 | +19,043 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 15,888 | +15,888 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 0 | 15,700 | +15,700 | 0.00 | 0.15 | +0.15 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 11,501 | 23,745 | +12,244 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 84,307 | 87,966 | +3,659 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,429 | 2,967 | +1,538 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 1,400 | +1,400 | 0.00 | 0.04 | +0.04 | buy |
| Ikarian Capital, LLC | 49,031 | 49,415 | +384 | 0.14 | 0.14 | +0.00 | buy |
| CITIGROUP INC | 3,323 | 3,583 | +260 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,590 | 30,751 | +161 | 0.00 | 0.00 | -0.00 | buy |
| NewEdge Advisors, LLC | 0 | 104 | +104 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 2.01 | 1.70 | -0.31 | hold |
| Alyeska Investment Group, L.P. | 470,285 | 470,285 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Artisan Partners Limited Partnership | 688,950 | 688,950 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Samsara BioCapital, LLC | 396,000 | 396,000 | 0 | 0.65 | 0.64 | -0.00 | hold |
| US BANCORP \DE\ | 511 | 511 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 701 | 701 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,877 | 29,877 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 1,696 | 1,560 | -136 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,447 | 8,837 | -610 | 0.06 | 0.05 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 809 | 0 | -809 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 41,410 | 39,928 | -1,482 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 8,202 | 5,728 | -2,474 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 4,787 | 1,874 | -2,913 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 22,000 | 16,200 | -5,800 | 0.10 | 0.05 | -0.06 | sell |
| JANE STREET GROUP, LLC | 40,386 | 32,698 | -7,688 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 9,524 | 0 | -9,524 | 0.01 | 0.00 | -0.01 | sell |
| Texas Capital Bank Wealth Management Services Inc | 10,000 | 0 | -10,000 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 10,653 | 0 | -10,653 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 10,793 | 0 | -10,793 | 0.01 | 0.00 | -0.01 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 13,761 | 0 | -13,761 | 0.00 | 0.00 | -0.00 | sell |
| TORNO CAPITAL, LLC | 20,000 | 0 | -20,000 | 0.22 | 0.00 | -0.22 | sell |
| JPMORGAN CHASE & CO | 291,571 | 271,450 | -20,121 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 313,574 | 288,689 | -24,885 | 0.13 | 0.12 | -0.01 | sell |
| Walleye Trading LLC | 26,024 | 0 | -26,024 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 29,000 | 0 | -29,000 | 0.03 | 0.00 | -0.03 | sell |
| STATE STREET CORP | 30,100 | 0 | -30,100 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 44,773 | 0 | -44,773 | 0.01 | 0.00 | -0.01 | sell |
| Jump Financial, LLC | 48,484 | 0 | -48,484 | 0.02 | 0.00 | -0.02 | sell |
| HRT FINANCIAL LP | 53,930 | 0 | -53,930 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 704,391 | 637,954 | -66,437 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 67,015 | 0 | -67,015 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 774,410 | 701,487 | -72,923 | 0.01 | 0.01 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 79,213 | 0 | -79,213 | 0.60 | 0.00 | -0.60 | sell |
| TWO SIGMA INVESTMENTS, LP | 334,016 | 220,123 | -113,893 | 0.01 | 0.01 | -0.00 | sell |
| Exome Asset Management LLC | 129,900 | 0 | -129,900 | 1.35 | 0.00 | -1.35 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621,500 | 481,252 | -140,248 | 0.01 | 0.01 | -0.00 | sell |
| 683 Capital Management, LLC | 1,100,000 | 900,000 | -200,000 | 1.16 | 0.96 | -0.20 | sell |
| Hudson Bay Capital Management LP | 475,580 | 225,023 | -250,557 | 0.04 | 0.02 | -0.02 | sell |
| Tri Locum Partners LP | 275,482 | 0 | -275,482 | 1.42 | 0.00 | -1.42 | sell |
| LORD, ABBETT & CO. LLC | 281,284 | 0 | -281,284 | 0.01 | 0.00 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 1,020,214 | 491,926 | -528,288 | 2.89 | 1.38 | -1.51 | sell |
| Nantahala Capital Management, LLC | 1,413,956 | 787,974 | -625,982 | 1.49 | 0.81 | -0.68 | sell |
| Sofinnova Investments, Inc. | 2,969,039 | 2,163,646 | -805,393 | 1.75 | 1.34 | -0.41 | sell |
| Vestal Point Capital, LP | 2,100,000 | 1,200,000 | -900,000 | 2.34 | 1.04 | -1.30 | sell |
| Rock Springs Capital Management LP | 1,875,466 | 848,751 | -1,026,715 | 0.49 | 0.23 | -0.26 | sell |