| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 10,604,777 | 14,677,003 | +4,072,226 | 0.05 | 0.04 | -0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,065,277 | 9,135,029 | +4,069,752 | 1.33 | 1.67 | +0.33 | buy |
| TORONTO DOMINION BANK | 0 | 2,973,032 | +2,973,032 | 0.00 | 0.03 | +0.03 | buy |
| Sofinnova Investments, Inc. | 343,206 | 1,554,304 | +1,211,098 | 0.18 | 0.53 | +0.35 | buy |
| Vestal Point Capital, LP | 6,275,000 | 7,192,700 | +917,700 | 2.65 | 2.32 | -0.33 | buy |
| MORGAN STANLEY | 2,438,046 | 3,093,614 | +655,568 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 347,379 | 719,586 | +372,207 | 0.00 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 6,540,540 | 6,909,510 | +368,970 | 0.70 | 0.48 | -0.23 | buy |
| Qube Research & Technologies Ltd | 185,960 | 479,085 | +293,125 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 173,518 | +173,518 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 168,037 | +168,037 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 126,957 | +126,957 | 0.00 | 0.03 | +0.03 | buy |
| Man Group plc | 0 | 120,447 | +120,447 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 95,383 | +95,383 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 152,510 | 228,293 | +75,783 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 686,181 | 758,333 | +72,152 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 48,613 | +48,613 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 18,338 | 58,519 | +40,181 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1 | 38,065 | +38,064 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 776 | 25,311 | +24,535 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 35,652 | 59,282 | +23,630 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 22,629 | +22,629 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 22,153 | +22,153 | 0.00 | 0.03 | +0.03 | buy |
| Quadrature Capital Ltd | 0 | 17,940 | +17,940 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 15,613 | +15,613 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 0 | 15,500 | +15,500 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 62,077 | 75,298 | +13,221 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 13,155 | 25,580 | +12,425 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 58,596 | 70,668 | +12,072 | 0.01 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 24,734 | 29,463 | +4,729 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 31,462 | 34,270 | +2,808 | 0.05 | 0.02 | -0.03 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 22,701 | 24,778 | +2,077 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 14,210 | 15,664 | +1,454 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 374 | +374 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 213 | +213 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 15,911 | 15,971 | +60 | 0.05 | 0.08 | +0.03 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 0.59 | 0.54 | -0.05 | hold |
| ORBIMED ADVISORS LLC | 3,087,462 | 3,087,462 | 0 | 0.46 | 0.33 | -0.12 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 427,994 | 427,994 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 9,383,456 | 9,383,456 | 0 | 1.86 | 1.50 | -0.36 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 311,722 | 311,722 | 0 | 0.13 | 0.08 | -0.05 | hold |
| BAKER BROS. ADVISORS LP | 7,275,830 | 7,275,830 | 0 | 0.55 | 0.36 | -0.19 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,750,000 | 1,750,000 | 0 | 0.17 | 0.13 | -0.03 | hold |
| DAFNA Capital Management LLC | 245,000 | 245,000 | 0 | 0.44 | 0.31 | -0.13 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.01 | 0.00 | -0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 921,111 | 921,111 | 0 | 1.21 | 1.02 | -0.19 | hold |
| NewEdge Advisors, LLC | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bell Investment Advisors, Inc | 64 | 64 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 1,861 | 1,758 | -103 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 126 | 0 | -126 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 30,364 | 29,877 | -487 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 940 | 0 | -940 | 0.01 | 0.00 | -0.01 | sell |
| NORTHERN TRUST CORP | 47,226 | 44,585 | -2,641 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,594 | 0 | -9,594 | 0.03 | 0.00 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 254,282 | 241,246 | -13,036 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 15,538 | 0 | -15,538 | 0.06 | 0.00 | -0.06 | sell |
| TWO SIGMA INVESTMENTS, LP | 70,324 | 53,129 | -17,195 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 18,700 | 0 | -18,700 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,587 | 0 | -27,587 | 0.00 | 0.00 | -0.00 | sell |
| Aristides Capital LLC | 28,900 | 0 | -28,900 | 0.06 | 0.00 | -0.06 | sell |
| Y-Intercept (Hong Kong) Ltd | 29,624 | 0 | -29,624 | 0.01 | 0.00 | -0.01 | sell |
| 683 Capital Management, LLC | 650,000 | 615,000 | -35,000 | 0.45 | 0.28 | -0.17 | sell |
| CITADEL ADVISORS LLC | 328,765 | 287,870 | -40,895 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 111,267 | 68,451 | -42,816 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 57,487 | 0 | -57,487 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 67,369 | 0 | -67,369 | 0.00 | 0.00 | -0.00 | sell |
| Aquilo Capital Management, LLC | 373,902 | 304,902 | -69,000 | 4.55 | 3.71 | -0.84 | sell |
| UBS Group AG | 270,449 | 193,264 | -77,185 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 84,166 | 0 | -84,166 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 93,279 | 0 | -93,279 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 97,085 | 0 | -97,085 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 156,686 | 55,127 | -101,559 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 286,769 | 151,179 | -135,590 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 162,504 | 6,839 | -155,665 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 165,000 | 0 | -165,000 | 0.21 | 0.00 | -0.21 | sell |
| Samsara BioCapital, LLC | 198,000 | 0 | -198,000 | 0.19 | 0.00 | -0.19 | sell |
| Zimmer Partners, LP | 405,000 | 145,990 | -259,010 | 0.05 | 0.01 | -0.04 | sell |
| Cubist Systematic Strategies, LLC | 278,382 | 0 | -278,382 | 0.03 | 0.00 | -0.03 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 330,002 | 0 | -330,002 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 2,034,224 | 1,684,285 | -349,939 | 0.10 | 0.05 | -0.05 | sell |
| WASATCH ADVISORS LP | 957,052 | 577,663 | -379,389 | 0.03 | 0.01 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 2,380,406 | 1,987,292 | -393,114 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 578,856 | 0 | -578,856 | 0.29 | 0.00 | -0.29 | sell |
| Artisan Partners Limited Partnership | 645,607 | 0 | -645,607 | 0.01 | 0.00 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 2,147,911 | 1,247,911 | -900,000 | 0.63 | 0.26 | -0.38 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 10,417,892 | 8,583,568 | -1,834,324 | 0.01 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,461,592 | 0 | -2,461,592 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 3,503,965 | 0 | -3,503,965 | 0.74 | 0.00 | -0.74 | sell |
| Paradigm Biocapital Advisors LP | 5,414,409 | 1,907,108 | -3,507,301 | 1.34 | 0.40 | -0.94 | sell |