| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 0 | 7,436,342 | +7,436,342 | 0.00 | 0.14 | +0.14 | buy |
| RTW INVESTMENTS, LP | 11,433,354 | 12,869,340 | +1,435,986 | 1.20 | 1.26 | +0.06 | buy |
| Longaeva Partners L.P. | 44,601 | 780,967 | +736,366 | 0.06 | 0.37 | +0.31 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 592,428 | 982,864 | +390,436 | 0.01 | 0.02 | +0.01 | buy |
| Atom Investors LP | 0 | 254,140 | +254,140 | 0.00 | 0.18 | +0.18 | buy |
| Troluce Capital Advisors LLC | 0 | 250,000 | +250,000 | 0.00 | 0.26 | +0.26 | buy |
| Qube Research & Technologies Ltd | 147,328 | 366,772 | +219,444 | 0.00 | 0.01 | +0.00 | buy |
| Sofinnova Investments, Inc. | 3,435,542 | 3,630,454 | +194,912 | 1.56 | 1.79 | +0.23 | buy |
| T. Rowe Price Investment Management, Inc. | 21,459,156 | 21,652,162 | +193,006 | 0.14 | 0.15 | +0.00 | buy |
| Tidal Investments LLC | 0 | 170,389 | +170,389 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,714,961 | 1,851,963 | +137,002 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 83,122 | 215,721 | +132,599 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 714,569 | 820,717 | +106,148 | 0.01 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 75,427 | +75,427 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,089,796 | 2,149,082 | +59,286 | 0.00 | 0.00 | -0.00 | buy |
| SummitTX Capital, L.P. | 96,784 | 151,112 | +54,328 | 0.03 | 0.05 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 50,165 | +50,165 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 6,125,000 | 6,175,000 | +50,000 | 2.36 | 1.70 | -0.66 | buy |
| Engineers Gate Manager LP | 0 | 40,248 | +40,248 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 28,185 | 64,654 | +36,469 | 0.00 | 0.00 | +0.00 | buy |
| Prime Capital Investment Advisors, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Robeco Institutional Asset Management B.V. | 0 | 24,034 | +24,034 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 21,094 | +21,094 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 444,658 | 456,998 | +12,340 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 54,720 | 67,048 | +12,328 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 8,001 | 18,750 | +10,749 | 0.01 | 0.04 | +0.02 | buy |
| Graham Capital Management, L.P. | 19,630 | 25,169 | +5,539 | 0.01 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,891 | +4,891 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 12,307 | 16,957 | +4,650 | 0.02 | 0.03 | +0.01 | buy |
| CITIGROUP INC | 56,367 | 60,914 | +4,547 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 63,015 | 66,830 | +3,815 | 0.53 | 0.57 | +0.04 | buy |
| XTX Topco Ltd | 11,234 | 14,293 | +3,059 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 0 | 2,232 | +2,232 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 25,554 | 26,600 | +1,046 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 20,220 | 21,173 | +953 | 0.01 | 0.01 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 866 | +866 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 26,497 | 27,159 | +662 | 0.08 | 0.07 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 191 | +191 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 16,402 | 16,583 | +181 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 13,405 | 13,453 | +48 | 0.00 | 0.00 | -0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 1.04 | 1.00 | -0.04 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 402,352 | 402,352 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 10,383,456 | 10,383,456 | 0 | 2.00 | 2.02 | +0.02 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,190,129 | 11,190,129 | 0 | 2.93 | 2.99 | +0.06 | hold |
| MYDA Advisors LLC | 120,000 | 120,000 | 0 | 0.35 | 0.28 | -0.08 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ikarian Capital, LLC | 48,569 | 48,569 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Woodline Partners LP | 1,000,597 | 1,000,597 | 0 | 0.04 | 0.04 | -0.00 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.10 | 0.07 | -0.03 | hold |
| Pale Fire Capital SE | 16,272 | 16,272 | 0 | 0.02 | 0.01 | -0.01 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,987 | 29,987 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,300 | 55,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 5,059,551 | 5,059,551 | 0 | 0.44 | 0.61 | +0.17 | hold |
| Farther Finance Advisors, LLC | 528 | 335 | -193 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 16,955 | 16,546 | -409 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 134,763 | 134,277 | -486 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 110,082 | 109,138 | -944 | 0.01 | 0.01 | -0.00 | sell |
| Jump Financial, LLC | 50,868 | 48,339 | -2,529 | 0.01 | 0.01 | +0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 49,374 | 44,890 | -4,484 | 0.01 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 146,972 | 140,465 | -6,507 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 116,646 | 104,023 | -12,623 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 500,724 | 470,444 | -30,280 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 261,138 | 225,860 | -35,278 | 0.64 | 0.51 | -0.13 | sell |
| WASATCH ADVISORS LP | 515,128 | 464,823 | -50,305 | 0.03 | 0.03 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,635,231 | 1,561,892 | -73,339 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 748,035 | 652,170 | -95,865 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 104,929 | 0 | -104,929 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 323,023 | 215,978 | -107,045 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 208,456 | 99,441 | -109,015 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 160,336 | 0 | -160,336 | 0.95 | 0.00 | -0.95 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 861,105 | 696,105 | -165,000 | 1.89 | 1.18 | -0.71 | sell |
| NORTHERN TRUST CORP | 203,449 | 36,442 | -167,007 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 206,568 | 0 | -206,568 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 1,754,181 | 1,493,800 | -260,381 | 0.03 | 0.03 | -0.00 | sell |
| UBS Group AG | 563,463 | 261,007 | -302,456 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 550,891 | 0 | -550,891 | 0.26 | 0.00 | -0.26 | sell |
| STEMPOINT CAPITAL LP | 610,308 | 0 | -610,308 | 1.10 | 0.00 | -1.10 | sell |
| Lynx1 Capital Management LP | 921,950 | 216,973 | -704,977 | 1.96 | 0.34 | -1.62 | sell |
| Alyeska Investment Group, L.P. | 789,163 | 0 | -789,163 | 0.02 | 0.00 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 12,094,094 | 10,916,693 | -1,177,401 | 0.74 | 0.62 | -0.13 | sell |