| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 11,433,354 | 12,869,340 | +1,435,986 | 1.20 | 1.26 | +0.06 | buy |
| Longaeva Partners L.P. | 44,601 | 780,967 | +736,366 | 0.06 | 0.37 | +0.31 | buy |
| Sofinnova Investments, Inc. | 3,435,542 | 3,630,454 | +194,912 | 1.56 | 1.79 | +0.23 | buy |
| T. Rowe Price Investment Management, Inc. | 21,459,156 | 21,652,162 | +193,006 | 0.14 | 0.15 | +0.00 | buy |
| Aberdeen Group plc | 714,569 | 820,717 | +106,148 | 0.01 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 96,784 | 151,112 | +54,328 | 0.03 | 0.05 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 12,307 | 16,957 | +4,650 | 0.02 | 0.03 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 63,015 | 66,830 | +3,815 | 0.53 | 0.57 | +0.04 | buy |
| DAFNA Capital Management LLC | 261,138 | 225,860 | -35,278 | 0.64 | 0.51 | -0.13 | sell |
| WASATCH ADVISORS LP | 515,128 | 464,823 | -50,305 | 0.03 | 0.03 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 861,105 | 696,105 | -165,000 | 1.89 | 1.18 | -0.71 | sell |
| BAKER BROS. ADVISORS LP | 12,094,094 | 10,916,693 | -1,177,401 | 0.74 | 0.62 | -0.13 | sell |