| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 4,582,409 | 8,086,159 | +3,503,750 | 0.84 | 2.26 | +1.42 | buy |
| Vestal Point Capital, LP | 1,200,000 | 2,750,000 | +1,550,000 | 1.04 | 2.38 | +1.34 | buy |
| T. Rowe Price Investment Management, Inc. | 6,304,672 | 7,433,707 | +1,129,035 | 0.04 | 0.05 | +0.01 | buy |
| Woodline Partners LP | 2,373,987 | 3,262,010 | +888,023 | 0.23 | 0.36 | +0.13 | buy |
| BAKER BROS. ADVISORS LP | 5,838,853 | 6,443,398 | +604,545 | 0.70 | 0.96 | 0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,818,908 | 3,421,965 | +603,057 | 1.04 | 1.52 | +0.48 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,225,360 | 3,639,562 | +414,202 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 481,252 | 751,252 | +270,000 | 0.01 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 1,769,708 | 2,006,381 | +236,673 | 0.34 | 0.46 | +0.12 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,739 | 280,447 | +142,708 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 730,394 | 843,272 | +112,878 | 0.04 | 0.05 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 666,111 | 731,111 | +65,000 | 0.98 | 1.16 | +0.18 | buy |
| TD ASSET MANAGEMENT INC | 319,756 | 357,526 | +37,770 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 491,926 | 502,207 | +10,281 | 1.38 | 1.72 | +0.34 | buy |
| Crestline Management, LP | 122,036 | 126,325 | +4,289 | 0.11 | 0.11 | +0.00 | buy |
| nVerses Capital, LLC | 1,400 | 1,000 | -400 | 0.04 | 0.01 | -0.03 | sell |
| Artisan Partners Limited Partnership | 688,950 | 688,484 | -466 | 0.01 | 0.01 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 8,837 | 6,990 | -1,847 | 0.05 | 0.04 | -0.01 | sell |
| ARISTEIA CAPITAL, L.L.C. | 839,058 | 832,328 | -6,730 | 0.09 | 0.08 | -0.01 | sell |
| J. Goldman & Co LP | 62,632 | 29,538 | -33,094 | 0.02 | 0.01 | -0.01 | sell |
| Zimmer Partners, LP | 397,000 | 360,000 | -37,000 | 0.09 | 0.08 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 350,000 | 300,000 | -50,000 | 0.60 | 0.55 | -0.05 | sell |
| 683 Capital Management, LLC | 900,000 | 815,000 | -85,000 | 0.69 | 0.72 | +0.02 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 288,689 | 203,614 | -85,075 | 0.12 | 0.10 | -0.03 | sell |
| Samsara BioCapital, LLC | 396,000 | 198,000 | -198,000 | 0.64 | 0.48 | -0.16 | sell |
| Sofinnova Investments, Inc. | 2,163,646 | 796,704 | -1,366,942 | 1.27 | 0.48 | -0.79 | sell |