| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 10,000,000 | 10,000,000 | 0 | 1.55 | 1.80 | +0.25 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 8,326,332 | 9,536,634 | +1,210,302 | 0.02 | 0.02 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 4,582,409 | 8,086,159 | +3,503,750 | 0.85 | 2.27 | +1.42 | buy |
| T. Rowe Price Investment Management, Inc. | 6,304,672 | 7,433,707 | +1,129,035 | 0.04 | 0.05 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 6,443,398 | 6,443,398 | 0 | 0.85 | 0.96 | +0.11 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,225,360 | 3,639,562 | +414,202 | 0.00 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,818,908 | 3,421,965 | +603,057 | 1.04 | 1.52 | +0.48 | buy |
| Woodline Partners LP | 2,373,987 | 3,262,010 | +888,023 | 0.23 | 0.36 | +0.13 | buy |
| Vestal Point Capital, LP | 1,200,000 | 2,750,000 | +1,550,000 | 1.04 | 2.38 | +1.34 | buy |
| ORBIMED ADVISORS LLC | 1,769,708 | 2,006,381 | +236,673 | 0.34 | 0.46 | +0.12 | buy |
| GOLDMAN SACHS GROUP INC | 1,809,269 | 1,752,355 | -56,914 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,750,000 | 1,750,000 | 0 | 0.23 | 0.27 | +0.03 | hold |
| Frazier Life Sciences Management, L.P. | 0 | 1,152,456 | +1,152,456 | 0.00 | 0.63 | +0.63 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 946,563 | 946,563 | 0 | 0.42 | 0.45 | +0.03 | hold |
| CITADEL ADVISORS LLC | 701,487 | 885,407 | +183,920 | 0.01 | 0.01 | +0.00 | buy |
| WASATCH ADVISORS LP | 730,394 | 843,272 | +112,878 | 0.04 | 0.05 | +0.01 | buy |
| 683 Capital Management, LLC | 900,000 | 815,000 | -85,000 | 0.96 | 0.99 | +0.03 | sell |
| Sofinnova Investments, Inc. | 2,163,646 | 796,704 | -1,366,942 | 1.34 | 0.58 | -0.76 | sell |
| Nantahala Capital Management, LLC | 787,974 | 787,974 | 0 | 0.81 | 0.92 | +0.11 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 481,252 | 751,252 | +270,000 | 0.01 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 666,111 | 731,111 | +65,000 | 1.13 | 1.38 | +0.25 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 1.70 | 1.58 | -0.12 | hold |
| Artisan Partners Limited Partnership | 688,950 | 688,484 | -466 | 0.01 | 0.01 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 491,926 | 502,207 | +10,281 | 1.38 | 1.72 | +0.34 | buy |
| Walleye Capital LLC | 660,179 | 419,393 | -240,786 | 0.08 | 0.05 | -0.02 | sell |
| MPM BioImpact LLC | 0 | 417,810 | +417,810 | 0.00 | 0.75 | +0.75 | buy |
| Avidity Partners Management LP | 0 | 393,100 | +393,100 | 0.00 | 0.19 | +0.19 | buy |
| Zimmer Partners, LP | 397,000 | 360,000 | -37,000 | 0.09 | 0.08 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 319,756 | 357,526 | +37,770 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 512,897 | 324,441 | -188,456 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 271,450 | 321,760 | +50,310 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 300,000 | -50,000 | 0.60 | 0.55 | -0.05 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 137,739 | 280,447 | +142,708 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 206,920 | +206,920 | 0.00 | 0.04 | +0.04 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 288,689 | 203,614 | -85,075 | 0.12 | 0.10 | -0.03 | sell |
| STATE STREET CORP | 0 | 202,492 | +202,492 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 2.24 | +2.24 | buy |
| Samsara BioCapital, LLC | 396,000 | 198,000 | -198,000 | 0.64 | 0.48 | -0.16 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 132,415 | 150,769 | +18,354 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 145,000 | 145,000 | 0 | 0.35 | 0.40 | +0.06 | hold |
| JANUS HENDERSON GROUP PLC | 637,954 | 133,284 | -504,670 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 220,123 | 130,999 | -89,124 | 0.01 | 0.00 | -0.00 | sell |
| Crestline Management, LP | 122,036 | 126,325 | +4,289 | 0.12 | 0.12 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 87,966 | 110,217 | +22,251 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 157,500 | 100,300 | -57,200 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 0 | 77,821 | +77,821 | 0.00 | 0.33 | +0.33 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 73,302 | +73,302 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 15,888 | 58,365 | +42,477 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 32,698 | 55,531 | +22,833 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 55,283 | +55,283 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 55,008 | +55,008 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 25,433 | 51,379 | +25,946 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 49,415 | 49,415 | 0 | 0.14 | 0.18 | +0.04 | hold |
| Jump Financial, LLC | 0 | 48,991 | +48,991 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 30,243 | 44,724 | +14,481 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 39,928 | 36,616 | -3,312 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,751 | 31,156 | +405 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 29,877 | 29,877 | 0 | 0.00 | 0.00 | +0.00 | hold |
| J. Goldman & Co LP | 62,632 | 29,538 | -33,094 | 0.03 | 0.01 | -0.02 | sell |
| XTX Topco Ltd | 0 | 27,587 | +27,587 | 0.00 | 0.03 | +0.03 | buy |
| Engineers Gate Manager LP | 23,832 | 25,342 | +1,510 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 224,908 | 22,275 | -202,633 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 0 | 21,339 | +21,339 | 0.00 | 0.13 | +0.13 | buy |
| ALGERT GLOBAL LLC | 0 | 20,818 | +20,818 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 20,552 | +20,552 | 0.00 | 0.03 | +0.03 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 19,944 | +19,944 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 23,745 | 18,111 | -5,634 | 0.01 | 0.01 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 15,700 | 15,700 | 0 | 0.15 | 0.19 | +0.04 | hold |
| Forefront Analytics, LLC | 0 | 11,987 | +11,987 | 0.00 | 0.07 | +0.07 | buy |
| Pale Fire Capital SE | 0 | 11,524 | +11,524 | 0.00 | 0.02 | +0.02 | buy |
| Quarry LP | 0 | 8,500 | +8,500 | 0.00 | 0.04 | +0.04 | buy |
| VIRTUS ADVISERS, LLC | 8,837 | 6,990 | -1,847 | 0.05 | 0.04 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 5,728 | 1,544 | -4,184 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 3,583 | 1,537 | -2,046 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 1,560 | 1,434 | -126 | 0.00 | 0.00 | +0.00 | sell |
| nVerses Capital, LLC | 1,400 | 1,000 | -400 | 0.04 | 0.01 | -0.03 | sell |
| HUNTINGTON NATIONAL BANK | 701 | 701 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 511 | 437 | -74 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bell Investment Advisors, Inc | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 225,023 | 0 | -225,023 | 0.02 | 0.00 | -0.02 | sell |
| Alyeska Investment Group, L.P. | 470,285 | 0 | -470,285 | 0.03 | 0.00 | -0.03 | sell |
| SIMPLEX TRADING, LLC | 1,874 | 0 | -1,874 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,967 | 0 | -2,967 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 848,751 | 0 | -848,751 | 0.23 | 0.00 | -0.23 | sell |
| VR Adviser, LLC | 1,750,000 | 0 | -1,750,000 | 0.87 | 0.00 | -0.87 | sell |
| Squarepoint Ops LLC | 19,043 | 0 | -19,043 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 24,437 | 0 | -24,437 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 1,000,000 | 0 | -1,000,000 | 1.11 | 0.00 | -1.11 | sell |
| ADAR1 Capital Management, LLC | 16,200 | 0 | -16,200 | 0.05 | 0.00 | -0.05 | sell |