| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 14,677,003 | 18,328,455 | +3,651,452 | 0.04 | 0.06 | +0.02 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9,135,029 | 12,030,129 | +2,895,100 | 1.53 | 1.95 | +0.42 | buy |
| BAKER BROS. ADVISORS LP | 7,275,830 | 10,168,901 | +2,893,071 | 0.36 | 0.53 | +0.17 | buy |
| Woodline Partners LP | 1,684,285 | 3,877,631 | +2,193,346 | 0.05 | 0.11 | +0.06 | buy |
| Paradigm Biocapital Advisors LP | 1,907,108 | 3,144,157 | +1,237,049 | 0.40 | 0.72 | +0.33 | buy |
| Sofinnova Investments, Inc. | 1,554,304 | 2,240,528 | +686,224 | 0.46 | 0.74 | +0.28 | buy |
| WASATCH ADVISORS LP | 577,663 | 785,154 | +207,491 | 0.01 | 0.02 | +0.01 | buy |
| RTW INVESTMENTS, LP | 6,909,510 | 6,970,152 | +60,642 | 0.48 | 0.53 | +0.06 | buy |
| Virtus Investment Advisers, LLC | 22,153 | 15,315 | -6,838 | 0.03 | 0.03 | +0.00 | sell |
| 683 Capital Management, LLC | 615,000 | 540,000 | -75,000 | 0.19 | 0.19 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 921,111 | 583,105 | -338,006 | 0.96 | 0.74 | -0.22 | sell |
| Vestal Point Capital, LP | 7,192,700 | 6,250,000 | -942,700 | 2.32 | 1.77 | -0.55 | sell |
| ORBIMED ADVISORS LLC | 3,087,462 | 719,901 | -2,367,561 | 0.33 | 0.10 | -0.24 | sell |