| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 14,677,003 | 18,328,455 | +3,651,452 | 0.04 | 0.06 | +0.02 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9,135,029 | 12,030,129 | +2,895,100 | 1.67 | 2.44 | +0.77 | buy |
| BAKER BROS. ADVISORS LP | 7,275,830 | 10,168,901 | +2,893,071 | 0.36 | 0.53 | +0.17 | buy |
| Woodline Partners LP | 1,684,285 | 3,877,631 | +2,193,346 | 0.05 | 0.11 | +0.06 | buy |
| Paradigm Biocapital Advisors LP | 1,907,108 | 3,144,157 | +1,237,049 | 0.40 | 0.72 | +0.33 | buy |
| Sofinnova Investments, Inc. | 1,554,304 | 2,240,528 | +686,224 | 0.53 | 0.82 | +0.29 | buy |
| CITADEL ADVISORS LLC | 287,870 | 879,235 | +591,365 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 332,270 | +332,270 | 0.00 | 1.18 | +1.18 | buy |
| UBS Group AG | 193,264 | 404,269 | +211,005 | 0.00 | 0.00 | +0.00 | buy |
| WASATCH ADVISORS LP | 577,663 | 785,154 | +207,491 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 44,585 | 232,375 | +187,790 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 0 | 120,000 | +120,000 | 0.00 | 0.18 | +0.18 | buy |
| ALPS ADVISORS INC | 0 | 65,582 | +65,582 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 60,920 | +60,920 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 6,909,510 | 6,970,152 | +60,642 | 0.48 | 0.53 | +0.06 | buy |
| Ikarian Capital, LLC | 0 | 49,396 | +49,396 | 0.00 | 0.09 | +0.09 | buy |
| JPMORGAN CHASE & CO | 151,179 | 198,769 | +47,590 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 241,246 | 288,256 | +47,010 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 43,969 | +43,969 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 38,065 | 78,123 | +40,058 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 25,233 | +25,233 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 0 | 23,133 | +23,133 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 13,740 | +13,740 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,557 | +12,557 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 24,778 | 31,894 | +7,116 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 1,820 | +1,820 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,690 | +1,690 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 374 | 1,924 | +1,550 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,081 | +1,081 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 15,664 | 16,557 | +893 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,758 | 2,321 | +563 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 335 | +335 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 68,451 | 68,732 | +281 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 29,877 | 29,987 | +110 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 104 | 204 | +100 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 0.54 | 0.59 | +0.05 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 427,994 | 427,994 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 9,383,456 | 9,383,456 | 0 | 1.50 | 1.89 | +0.39 | hold |
| DAFNA Capital Management LLC | 245,000 | 245,000 | 0 | 0.31 | 0.36 | +0.05 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Intellectus Partners, LLC | 15,500 | 15,500 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Aberdeen Group plc | 719,586 | 719,586 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pale Fire Capital SE | 34,270 | 34,270 | 0 | 0.02 | 0.02 | +0.00 | hold |
| BARCLAYS PLC | 25,311 | 25,311 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bell Investment Advisors, Inc | 64 | 0 | -64 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 80 | 0 | -80 | 0.00 | 0.00 | -0.00 | sell |
| SUMMIT SECURITIES GROUP LLC | 213 | 0 | -213 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 3,000 | 0 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 6,839 | 3,350 | -3,489 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 15,613 | 11,328 | -4,285 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 22,153 | 15,315 | -6,838 | 0.03 | 0.03 | +0.00 | sell |
| HRT FINANCIAL LP | 48,613 | 34,840 | -13,773 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 15,971 | 0 | -15,971 | 0.08 | 0.00 | -0.08 | sell |
| D. E. Shaw & Co., Inc. | 29,463 | 11,792 | -17,671 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 17,940 | 0 | -17,940 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 22,629 | 0 | -22,629 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 25,580 | 0 | -25,580 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 55,127 | 14,179 | -40,948 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 228,293 | 182,629 | -45,664 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 53,129 | 0 | -53,129 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 58,519 | 0 | -58,519 | 0.01 | 0.00 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 59,282 | 0 | -59,282 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 2,973,032 | 2,912,390 | -60,642 | 0.03 | 0.03 | -0.00 | sell |
| ALGERT GLOBAL LLC | 70,668 | 0 | -70,668 | 0.01 | 0.00 | -0.01 | sell |
| 683 Capital Management, LLC | 615,000 | 540,000 | -75,000 | 0.28 | 0.29 | +0.01 | sell |
| ExodusPoint Capital Management, LP | 75,298 | 0 | -75,298 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 95,383 | 0 | -95,383 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 120,447 | 0 | -120,447 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 126,957 | 0 | -126,957 | 0.03 | 0.00 | -0.03 | sell |
| Zimmer Partners, LP | 145,990 | 0 | -145,990 | 0.01 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 168,037 | 0 | -168,037 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 173,518 | 0 | -173,518 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 479,085 | 282,678 | -196,407 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 3,093,614 | 2,804,092 | -289,522 | 0.00 | 0.00 | -0.00 | sell |
| Aquilo Capital Management, LLC | 304,902 | 0 | -304,902 | 3.71 | 0.00 | -3.71 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 311,722 | 0 | -311,722 | 0.08 | 0.00 | -0.08 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 921,111 | 583,105 | -338,006 | 1.02 | 0.82 | -0.20 | sell |
| BlackRock, Inc. | 758,333 | 241,451 | -516,882 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 7,192,700 | 6,250,000 | -942,700 | 2.32 | 1.77 | -0.55 | sell |
| GOLDMAN SACHS GROUP INC | 1,987,292 | 1,034,825 | -952,467 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,247,911 | 0 | -1,247,911 | 0.26 | 0.00 | -0.26 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,750,000 | 0 | -1,750,000 | 0.13 | 0.00 | -0.13 | sell |
| ORBIMED ADVISORS LLC | 3,087,462 | 719,901 | -2,367,561 | 0.33 | 0.10 | -0.24 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 8,583,568 | 5,318,624 | -3,264,944 | 0.01 | 0.01 | -0.00 | sell |