| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 12,869,340 | 12,946,176 | +76,836 | 1.26 | 1.12 | -0.14 | buy |
| Sofinnova Investments, Inc. | 3,630,454 | 3,669,346 | +38,892 | 1.36 | 1.92 | +0.56 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 696,105 | 720,057 | +23,952 | 1.09 | 0.95 | -0.14 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 16,957 | 23,694 | +6,737 | 0.03 | 0.04 | +0.01 | buy |
| SummitTX Capital, L.P. | 151,112 | 146,351 | -4,761 | 0.05 | 0.04 | -0.01 | sell |
| WASATCH ADVISORS LP | 464,823 | 441,510 | -23,313 | 0.03 | 0.03 | -0.00 | sell |
| Atom Investors LP | 254,140 | 216,365 | -37,775 | 0.18 | 0.19 | +0.02 | sell |
| DAFNA Capital Management LLC | 225,860 | 116,960 | -108,900 | 0.51 | 0.23 | -0.28 | sell |
| Aberdeen Group plc | 820,717 | 653,604 | -167,113 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 10,916,693 | 9,508,565 | -1,408,128 | 0.62 | 0.48 | -0.13 | sell |