| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Jefferies Financial Group Inc. | 5,059,551 | 6,506,802 | +1,447,251 | 0.61 | 0.61 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 21,652,162 | 22,365,046 | +712,884 | 0.15 | 0.15 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 475,000 | +475,000 | 0.00 | 0.36 | +0.36 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 192,770 | +192,770 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 215,978 | 384,171 | +168,193 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 66,830 | 224,928 | +158,098 | 0.57 | 1.59 | +1.02 | buy |
| Qube Research & Technologies Ltd | 366,772 | 523,217 | +156,445 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 104,548 | +104,548 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,561,892 | 1,647,852 | +85,960 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 12,869,340 | 12,946,176 | +76,836 | 1.26 | 1.12 | -0.14 | buy |
| D. E. Shaw & Co., Inc. | 0 | 59,161 | +59,161 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 48,339 | 106,046 | +57,707 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 53,500 | +53,500 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 3,630,454 | 3,669,346 | +38,892 | 1.79 | 1.99 | +0.20 | buy |
| MORGAN STANLEY | 2,149,082 | 2,186,494 | +37,412 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 31,724 | +31,724 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 109,138 | 135,599 | +26,461 | 0.01 | 0.01 | +0.00 | buy |
| BRANDYWINE MANAGERS, LLC | 0 | 25,227 | +25,227 | 0.00 | 0.13 | +0.13 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 696,105 | 720,057 | +23,952 | 1.18 | 1.04 | -0.13 | buy |
| XTX Topco Ltd | 14,293 | 30,020 | +15,727 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 14,726 | +14,726 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 10,791 | +10,791 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 40,248 | 50,886 | +10,638 | 0.00 | 0.01 | +0.00 | buy |
| Prime Capital Investment Advisors, LLC | 30,000 | 40,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 27,159 | 34,882 | +7,723 | 0.07 | 0.08 | +0.01 | buy |
| BlackRock, Inc. | 26,600 | 33,914 | +7,314 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 134,277 | 141,400 | +7,123 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 16,957 | 23,694 | +6,737 | 0.03 | 0.04 | +0.01 | buy |
| CITIGROUP INC | 60,914 | 66,933 | +6,019 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 44,890 | 49,365 | +4,475 | 0.00 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 170,389 | 171,499 | +1,110 | 0.01 | 0.00 | -0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 600 | +600 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 1.00 | 0.82 | -0.18 | hold |
| PERCEPTIVE ADVISORS LLC | 10,383,456 | 10,383,456 | 0 | 2.02 | 1.63 | -0.39 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,190,129 | 11,190,129 | 0 | 2.99 | 2.38 | -0.60 | hold |
| MYDA Advisors LLC | 120,000 | 120,000 | 0 | 0.28 | 0.30 | +0.02 | hold |
| Ikarian Capital, LLC | 48,569 | 48,569 | 0 | 0.07 | 0.08 | +0.01 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Burkehill Global Management, LP | 150,000 | 150,000 | 0 | 0.07 | 0.05 | -0.02 | hold |
| Vestal Point Capital, LP | 6,175,000 | 6,175,000 | 0 | 1.70 | 1.46 | -0.24 | hold |
| Farther Finance Advisors, LLC | 335 | 335 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 2,232 | 2,232 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,987 | 29,987 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 52 | 0 | -52 | 0.00 | 0.00 | -0.00 | sell |
| NewEdge Advisors, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 16,583 | 16,434 | -149 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 191 | 0 | -191 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 36,442 | 36,128 | -314 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 13,453 | 13,100 | -353 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 866 | 258 | -608 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 67,048 | 66,434 | -614 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 16,546 | 15,299 | -1,247 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 25,169 | 22,725 | -2,444 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 140,465 | 137,074 | -3,391 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 151,112 | 146,351 | -4,761 | 0.05 | 0.04 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 4,891 | 0 | -4,891 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 21,173 | 14,097 | -7,076 | 0.01 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 99,441 | 87,277 | -12,164 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 18,750 | 3,926 | -14,824 | 0.04 | 0.01 | -0.03 | sell |
| ExodusPoint Capital Management, LP | 50,165 | 34,937 | -15,228 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 16,272 | 0 | -16,272 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 64,654 | 46,265 | -18,389 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 21,094 | 0 | -21,094 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 470,444 | 449,348 | -21,096 | 0.00 | 0.00 | +0.00 | sell |
| WASATCH ADVISORS LP | 464,823 | 441,510 | -23,313 | 0.03 | 0.03 | -0.00 | sell |
| Robeco Institutional Asset Management B.V. | 24,034 | 0 | -24,034 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55,300 | 21,977 | -33,323 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 456,998 | 419,698 | -37,300 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,851,963 | 1,814,657 | -37,306 | 0.01 | 0.01 | -0.00 | sell |
| Atom Investors LP | 254,140 | 216,365 | -37,775 | 0.18 | 0.19 | +0.02 | sell |
| Point72 Asset Management, L.P. | 1,493,800 | 1,449,597 | -44,203 | 0.03 | 0.02 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 104,023 | 43,297 | -60,726 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 75,427 | 0 | -75,427 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 1,000,597 | 900,736 | -99,861 | 0.04 | 0.03 | -0.01 | sell |
| DAFNA Capital Management LLC | 225,860 | 116,960 | -108,900 | 0.51 | 0.23 | -0.28 | sell |
| MILLENNIUM MANAGEMENT LLC | 215,721 | 104,710 | -111,011 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 820,717 | 653,604 | -167,113 | 0.01 | 0.01 | -0.00 | sell |
| Lynx1 Capital Management LP | 216,973 | 23,236 | -193,737 | 0.34 | 0.03 | -0.31 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 402,352 | 197,300 | -205,052 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 652,170 | 410,712 | -241,458 | 0.00 | 0.00 | -0.00 | sell |
| Troluce Capital Advisors LLC | 250,000 | 0 | -250,000 | 0.26 | 0.00 | -0.26 | sell |
| UBS Group AG | 261,007 | 0 | -261,007 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 982,864 | 401,643 | -581,221 | 0.02 | 0.01 | -0.01 | sell |
| Longaeva Partners L.P. | 780,967 | 0 | -780,967 | 0.37 | 0.00 | -0.37 | sell |
| BAKER BROS. ADVISORS LP | 10,916,693 | 9,508,565 | -1,408,128 | 0.62 | 0.48 | -0.13 | sell |
| TORONTO DOMINION BANK | 7,436,342 | 0 | -7,436,342 | 0.14 | 0.00 | -0.14 | sell |