| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 0 | 1,647,565 | +1,647,565 | 0.00 | 0.53 | +0.53 | buy |
| CITADEL ADVISORS LLC | 885,407 | 1,920,843 | +1,035,436 | 0.01 | 0.02 | +0.01 | buy |
| Vestal Point Capital, LP | 2,750,000 | 3,750,000 | +1,000,000 | 2.38 | 3.38 | +0.99 | buy |
| Paradigm Biocapital Advisors LP | 3,421,965 | 3,904,862 | +482,897 | 1.52 | 1.56 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 0 | 451,476 | +451,476 | 0.00 | 0.05 | +0.05 | buy |
| Aberdeen Group plc | 0 | 232,900 | +232,900 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 215,449 | +215,449 | 0.00 | 0.01 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 1,152,456 | 1,354,711 | +202,255 | 0.63 | 0.62 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 9,536,634 | 9,681,183 | +144,549 | 0.02 | 0.02 | -0.00 | buy |
| Aquilo Capital Management, LLC | 200,000 | 333,502 | +133,502 | 2.24 | 4.28 | +2.04 | buy |
| D. E. Shaw & Co., Inc. | 0 | 63,647 | +63,647 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 51,102 | +51,102 | 0.00 | 0.06 | +0.06 | buy |
| WASATCH ADVISORS LP | 843,272 | 872,511 | +29,239 | 0.05 | 0.05 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 26,100 | +26,100 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 24,282 | +24,282 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 202,492 | 225,202 | +22,710 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 18,900 | +18,900 | 0.00 | 0.02 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 14,798 | +14,798 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 150,769 | 164,766 | +13,997 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 13,829 | +13,829 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 11,524 | 24,462 | +12,938 | 0.02 | 0.04 | +0.03 | buy |
| Crestline Management, LP | 126,325 | 136,721 | +10,396 | 0.12 | 0.09 | -0.03 | buy |
| Texas Capital Bank Wealth Management Services Inc | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Corton Capital Inc. | 21,339 | 25,439 | +4,100 | 0.13 | 0.14 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,606 | +3,606 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 8,500 | 11,000 | +2,500 | 0.04 | 0.04 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 357,526 | 359,244 | +1,718 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 20,818 | 21,458 | +640 | 0.01 | 0.01 | -0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 6,990 | 7,115 | +125 | 0.04 | 0.04 | -0.00 | buy |
| American Capital Advisory, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 1.58 | 1.29 | -0.29 | hold |
| ORBIMED ADVISORS LLC | 2,006,381 | 2,006,381 | 0 | 0.46 | 0.42 | -0.04 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 280,447 | 280,447 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 8,086,159 | 8,086,159 | 0 | 2.27 | 1.98 | -0.29 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 203,614 | 203,614 | 0 | 0.10 | 0.11 | +0.01 | hold |
| BAKER BROS. ADVISORS LP | 6,443,398 | 6,443,398 | 0 | 0.96 | 0.76 | -0.19 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,750,000 | 1,750,000 | 0 | 0.27 | 0.23 | -0.04 | hold |
| DAFNA Capital Management LLC | 145,000 | 145,000 | 0 | 0.40 | 0.39 | -0.01 | hold |
| RTW INVESTMENTS, LP | 10,000,000 | 10,000,000 | 0 | 1.80 | 1.65 | -0.15 | hold |
| NewEdge Advisors, LLC | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 198,000 | 198,000 | 0 | 0.48 | 0.43 | -0.05 | hold |
| Ikarian Capital, LLC | 49,415 | 49,415 | 0 | 0.18 | 0.18 | -0.00 | hold |
| BARCLAYS PLC | 1,434 | 1,434 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,877 | 29,877 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| Bell Investment Advisors, Inc | 45 | 0 | -45 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 1,537 | 1,365 | -172 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 110,217 | 110,007 | -210 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 437 | 204 | -233 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 36,616 | 35,922 | -694 | 0.00 | 0.00 | -0.00 | sell |
| HUNTINGTON NATIONAL BANK | 701 | 1 | -700 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 1,000 | 200 | -800 | 0.01 | 0.00 | -0.01 | sell |
| Forefront Analytics, LLC | 11,987 | 11,180 | -807 | 0.07 | 0.06 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 1,544 | 87 | -1,457 | 0.00 | 0.00 | -0.00 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 19,944 | 18,224 | -1,720 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,156 | 27,587 | -3,569 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 18,111 | 13,155 | -4,956 | 0.01 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 29,538 | 22,788 | -6,750 | 0.01 | 0.01 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 731,111 | 721,111 | -10,000 | 1.38 | 1.35 | -0.04 | sell |
| Engineers Gate Manager LP | 25,342 | 12,729 | -12,613 | 0.01 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 27,587 | 14,116 | -13,471 | 0.03 | 0.01 | -0.02 | sell |
| TUDOR INVESTMENT CORP ET AL | 51,379 | 36,011 | -15,368 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 48,991 | 33,600 | -15,391 | 0.01 | 0.01 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 15,700 | 0 | -15,700 | 0.19 | 0.00 | -0.19 | sell |
| Bayesian Capital Management, LP | 20,552 | 0 | -20,552 | 0.03 | 0.00 | -0.03 | sell |
| Qube Research & Technologies Ltd | 22,275 | 0 | -22,275 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 321,760 | 299,066 | -22,694 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 130,999 | 106,669 | -24,330 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 688,484 | 661,317 | -27,167 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 751,252 | 721,252 | -30,000 | 0.02 | 0.01 | -0.00 | sell |
| Trexquant Investment LP | 55,008 | 23,721 | -31,287 | 0.01 | 0.00 | -0.01 | sell |
| HighVista Strategies LLC | 77,821 | 45,544 | -32,277 | 0.33 | 0.18 | -0.15 | sell |
| TWO SIGMA ADVISERS, LP | 100,300 | 59,800 | -40,500 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 44,724 | 0 | -44,724 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 250,000 | -50,000 | 0.55 | 0.44 | -0.11 | sell |
| STEMPOINT CAPITAL LP | 502,207 | 449,735 | -52,472 | 1.72 | 1.54 | -0.18 | sell |
| T. Rowe Price Investment Management, Inc. | 7,433,707 | 7,379,636 | -54,071 | 0.05 | 0.05 | -0.00 | sell |
| Verition Fund Management LLC | 55,283 | 0 | -55,283 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 55,531 | 0 | -55,531 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 58,365 | 0 | -58,365 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 73,302 | 13,516 | -59,786 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 360,000 | 280,000 | -80,000 | 0.08 | 0.06 | -0.02 | sell |
| 683 Capital Management, LLC | 815,000 | 700,000 | -115,000 | 0.99 | 0.81 | -0.18 | sell |
| JANUS HENDERSON GROUP PLC | 133,284 | 0 | -133,284 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 419,393 | 282,193 | -137,200 | 0.05 | 0.03 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,639,562 | 3,494,502 | -145,060 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 324,441 | 163,571 | -160,870 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 787,974 | 625,659 | -162,315 | 0.92 | 0.60 | -0.32 | sell |
| Cubist Systematic Strategies, LLC | 206,920 | 35,394 | -171,526 | 0.04 | 0.01 | -0.04 | sell |
| Avidity Partners Management LP | 393,100 | 0 | -393,100 | 0.19 | 0.00 | -0.19 | sell |
| Sofinnova Investments, Inc. | 796,704 | 386,100 | -410,604 | 0.58 | 0.36 | -0.22 | sell |
| MPM BioImpact LLC | 417,810 | 0 | -417,810 | 0.75 | 0.00 | -0.75 | sell |
| Woodline Partners LP | 3,262,010 | 2,501,962 | -760,048 | 0.36 | 0.24 | -0.12 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 946,563 | 0 | -946,563 | 0.45 | 0.00 | -0.45 | sell |
| GOLDMAN SACHS GROUP INC | 1,752,355 | 114,265 | -1,638,090 | 0.00 | 0.00 | -0.00 | sell |