| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 2,750,000 | 3,750,000 | +1,000,000 | 2.38 | 3.38 | +0.99 | buy |
| Paradigm Biocapital Advisors LP | 3,421,965 | 3,904,862 | +482,897 | 1.52 | 1.56 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 1,152,456 | 1,354,711 | +202,255 | 0.63 | 0.62 | -0.01 | buy |
| Aquilo Capital Management, LLC | 200,000 | 333,502 | +133,502 | 2.24 | 4.28 | +2.04 | buy |
| WASATCH ADVISORS LP | 843,272 | 872,511 | +29,239 | 0.05 | 0.05 | -0.00 | buy |
| Pale Fire Capital SE | 11,524 | 24,462 | +12,938 | 0.02 | 0.04 | +0.03 | buy |
| Crestline Management, LP | 126,325 | 136,721 | +10,396 | 0.11 | 0.08 | -0.03 | buy |
| Corton Capital Inc. | 21,339 | 25,439 | +4,100 | 0.13 | 0.14 | +0.01 | buy |
| Quarry LP | 8,500 | 11,000 | +2,500 | 0.04 | 0.04 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 357,526 | 359,244 | +1,718 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 6,990 | 7,115 | +125 | 0.04 | 0.04 | -0.00 | buy |
| nVerses Capital, LLC | 1,000 | 200 | -800 | 0.01 | 0.00 | -0.01 | sell |
| Forefront Analytics, LLC | 11,987 | 11,180 | -807 | 0.07 | 0.06 | -0.01 | sell |
| J. Goldman & Co LP | 29,538 | 22,788 | -6,750 | 0.01 | 0.01 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 731,111 | 721,111 | -10,000 | 1.16 | 1.31 | +0.15 | sell |
| Artisan Partners Limited Partnership | 688,484 | 661,317 | -27,167 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 751,252 | 721,252 | -30,000 | 0.02 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 77,821 | 45,544 | -32,277 | 0.33 | 0.18 | -0.15 | sell |
| Affinity Asset Advisors, LLC | 300,000 | 250,000 | -50,000 | 0.55 | 0.44 | -0.11 | sell |
| STEMPOINT CAPITAL LP | 502,207 | 449,735 | -52,472 | 1.72 | 1.54 | -0.18 | sell |
| T. Rowe Price Investment Management, Inc. | 7,433,707 | 7,379,636 | -54,071 | 0.05 | 0.05 | -0.00 | sell |
| Zimmer Partners, LP | 360,000 | 280,000 | -80,000 | 0.08 | 0.06 | -0.02 | sell |
| 683 Capital Management, LLC | 815,000 | 700,000 | -115,000 | 0.72 | 0.61 | -0.11 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,639,562 | 3,494,502 | -145,060 | 0.01 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 787,974 | 625,659 | -162,315 | 0.54 | 0.36 | -0.17 | sell |
| Sofinnova Investments, Inc. | 796,704 | 386,100 | -410,604 | 0.48 | 0.35 | -0.13 | sell |
| Woodline Partners LP | 3,262,010 | 2,501,962 | -760,048 | 0.36 | 0.24 | -0.12 | sell |