| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 2,912,390 | 5,122,063 | +2,209,673 | 0.03 | 0.08 | +0.05 | buy |
| BAKER BROS. ADVISORS LP | 10,168,901 | 12,094,094 | +1,925,193 | 0.53 | 0.74 | +0.21 | buy |
| RTW INVESTMENTS, LP | 6,970,152 | 8,815,617 | +1,845,465 | 0.53 | 0.93 | +0.39 | buy |
| Jefferies Financial Group Inc. | 0 | 1,194,915 | +1,194,915 | 0.00 | 0.09 | +0.09 | buy |
| T. Rowe Price Investment Management, Inc. | 18,328,455 | 19,383,169 | +1,054,714 | 0.06 | 0.10 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 724,807 | +724,807 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,179 | 721,866 | +707,687 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 300,000 | +300,000 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 332,270 | 560,494 | +228,224 | 1.18 | 2.95 | +1.77 | buy |
| Point72 Asset Management, L.P. | 0 | 118,189 | +118,189 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 6,250,000 | 6,350,000 | +100,000 | 1.77 | 2.45 | +0.68 | buy |
| TD ASSET MANAGEMENT INC | 288,256 | 383,804 | +95,548 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 719,586 | 789,446 | +69,860 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 49,947 | +49,947 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 46,800 | +46,800 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 45,202 | +45,202 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 78,123 | 122,510 | +44,387 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 182,629 | 218,501 | +35,872 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 34,840 | 67,395 | +32,555 | 0.00 | 0.00 | +0.00 | buy |
| INSIGNEO ADVISORY SERVICES, LLC | 0 | 12,062 | +12,062 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 11,442 | +11,442 | 0.00 | 0.01 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 43,969 | 47,635 | +3,666 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 15,315 | 18,532 | +3,217 | 0.03 | 0.05 | +0.02 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 31,894 | 31,958 | +64 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 0.59 | 0.86 | +0.27 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 427,994 | 427,994 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 68,732 | 68,732 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 9,383,456 | 9,383,456 | 0 | 1.89 | 2.31 | +0.42 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.00 | 0.01 | +0.00 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 583,105 | 583,105 | 0 | 0.82 | 1.18 | +0.36 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,030,129 | 12,030,129 | 0 | 2.44 | 3.11 | +0.67 | hold |
| MYDA Advisors LLC | 120,000 | 120,000 | 0 | 0.18 | 0.31 | +0.13 | hold |
| Ikarian Capital, LLC | 49,396 | 49,396 | 0 | 0.09 | 0.09 | -0.00 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pale Fire Capital SE | 34,270 | 34,270 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Farther Finance Advisors, LLC | 335 | 335 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 25,311 | 25,311 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,987 | 29,987 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NewEdge Advisors, LLC | 204 | 100 | -104 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 13,740 | 13,550 | -190 | 0.00 | 0.00 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 16,557 | 16,278 | -279 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 11,000 | 10,000 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,081 | 0 | -1,081 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,690 | 0 | -1,690 | 0.00 | 0.00 | -0.00 | sell |
| Brooklyn Investment Group | 1,820 | 0 | -1,820 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 1,924 | 0 | -1,924 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 2,321 | 0 | -2,321 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 3,350 | 0 | -3,350 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 241,451 | 236,523 | -4,928 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 245,000 | 235,000 | -10,000 | 0.36 | 0.49 | +0.13 | sell |
| Squarepoint Ops LLC | 11,328 | 0 | -11,328 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 11,792 | 0 | -11,792 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 12,557 | 0 | -12,557 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 2,240,528 | 2,227,837 | -12,691 | 0.82 | 1.16 | +0.34 | sell |
| Intellectus Partners, LLC | 15,500 | 0 | -15,500 | 0.02 | 0.00 | -0.02 | sell |
| SummitTX Capital, L.P. | 60,920 | 44,466 | -16,454 | 0.01 | 0.02 | +0.00 | sell |
| NORTHERN TRUST CORP | 232,375 | 214,561 | -17,814 | 0.00 | 0.00 | +0.00 | sell |
| 683 Capital Management, LLC | 540,000 | 520,000 | -20,000 | 0.29 | 0.40 | +0.11 | sell |
| Engineers Gate Manager LP | 23,133 | 0 | -23,133 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 25,233 | 0 | -25,233 | 0.02 | 0.00 | -0.02 | sell |
| UBS Group AG | 404,269 | 349,379 | -54,890 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 198,769 | 135,957 | -62,812 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 65,582 | 0 | -65,582 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 785,154 | 718,897 | -66,257 | 0.02 | 0.03 | +0.01 | sell |
| Qube Research & Technologies Ltd | 282,678 | 154,753 | -127,925 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 719,901 | 466,601 | -253,300 | 0.10 | 0.10 | -0.00 | sell |
| CITADEL ADVISORS LLC | 879,235 | 603,155 | -276,080 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 2,804,092 | 2,205,321 | -598,771 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,034,825 | 190,759 | -844,066 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 3,877,631 | 1,841,602 | -2,036,029 | 0.11 | 0.07 | -0.04 | sell |
| Paradigm Biocapital Advisors LP | 3,144,157 | 0 | -3,144,157 | 0.72 | 0.00 | -0.72 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,318,624 | 1,512,241 | -3,806,383 | 0.01 | 0.00 | -0.00 | sell |