| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,614,535 | 2,334,169 | +719,634 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 845,000 | 1,484,911 | +639,911 | 0.21 | 0.24 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 2,230,836 | 2,824,169 | +593,333 | 0.02 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,050,200 | 1,543,407 | +493,207 | 0.26 | 0.33 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 326,500 | 621,500 | +295,000 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 5,640,816 | 5,838,853 | +198,037 | 0.38 | 0.70 | +0.32 | buy |
| Paradigm Biocapital Advisors LP | 2,058,447 | 2,136,339 | +77,892 | 1.63 | 1.05 | -0.57 | buy |
| Hudson Bay Capital Management LP | 400,580 | 475,580 | +75,000 | 0.04 | 0.03 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 268,211 | 313,574 | +45,363 | 0.12 | 0.13 | +0.01 | buy |
| Zimmer Partners, LP | 175,000 | 210,000 | +35,000 | 0.05 | 0.08 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 197,718 | 227,118 | +29,400 | 0.00 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 1,080,000 | 1,100,000 | +20,000 | 0.97 | 0.95 | -0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,600 | 29,000 | +16,400 | 0.01 | 0.03 | +0.01 | buy |
| BIT Capital GmbH | 5,143 | 9,524 | +4,381 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 617,173 | 621,111 | +3,938 | 1.30 | 1.05 | -0.25 | buy |
| VIRTUS ADVISERS, LLC | 8,263 | 9,447 | +1,184 | 0.06 | 0.06 | +0.01 | buy |
| LMR Partners LLP | 541,686 | 541,825 | +139 | 0.04 | 0.04 | -0.00 | buy |
| Artisan Partners Limited Partnership | 705,214 | 688,950 | -16,264 | 0.01 | 0.01 | -0.00 | sell |
| Tri Locum Partners LP | 304,974 | 275,482 | -29,492 | 1.13 | 1.42 | +0.29 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 50,400 | 13,761 | -36,639 | 0.01 | 0.00 | -0.01 | sell |
| ARISTEIA CAPITAL, L.L.C. | 919,872 | 857,758 | -62,114 | 0.13 | 0.10 | -0.03 | sell |
| LORD, ABBETT & CO. LLC | 513,773 | 281,284 | -232,489 | 0.02 | 0.01 | -0.01 | sell |
| Sofinnova Investments, Inc. | 3,251,509 | 2,969,039 | -282,470 | 2.38 | 1.75 | -0.63 | sell |
| Alyeska Investment Group, L.P. | 794,060 | 470,285 | -323,775 | 0.06 | 0.03 | -0.03 | sell |
| Woodline Partners LP | 2,400,000 | 2,070,083 | -329,917 | 0.33 | 0.24 | -0.09 | sell |
| Nantahala Capital Management, LLC | 1,920,636 | 1,413,956 | -506,680 | 1.90 | 0.89 | -1.01 | sell |