| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 365,049 | 1,548,909 | +1,183,860 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,605,157 | 6,352,929 | +747,772 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,614,535 | 2,334,169 | +719,634 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 704,391 | +704,391 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 845,000 | 1,484,911 | +639,911 | 0.21 | 0.24 | +0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 2,230,836 | 2,824,169 | +593,333 | 0.02 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,050,200 | 1,543,407 | +493,207 | 0.26 | 0.33 | +0.06 | buy |
| CITADEL ADVISORS LLC | 378,508 | 774,410 | +395,902 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 113,847 | 485,710 | +371,863 | 0.02 | 0.07 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 326,500 | 621,500 | +295,000 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 84,228 | 334,016 | +249,788 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 5,640,816 | 5,838,853 | +198,037 | 0.38 | 0.70 | +0.32 | buy |
| TWO SIGMA ADVISERS, LP | 27,541 | 137,800 | +110,259 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 105,000 | +105,000 | 0.00 | 0.26 | +0.26 | buy |
| Paradigm Biocapital Advisors LP | 2,058,447 | 2,136,339 | +77,892 | 1.63 | 1.05 | -0.57 | buy |
| Hudson Bay Capital Management LP | 400,580 | 475,580 | +75,000 | 0.04 | 0.04 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 53,930 | +53,930 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 268,211 | 313,574 | +45,363 | 0.12 | 0.13 | +0.01 | buy |
| Zimmer Partners, LP | 175,000 | 210,000 | +35,000 | 0.05 | 0.08 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 197,718 | 227,118 | +29,400 | 0.00 | 0.00 | -0.00 | buy |
| 683 Capital Management, LLC | 1,080,000 | 1,100,000 | +20,000 | 1.27 | 1.16 | -0.11 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12,600 | 29,000 | +16,400 | 0.01 | 0.03 | +0.01 | buy |
| NORTHERN TRUST CORP | 27,886 | 41,410 | +13,524 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 27,020 | 40,386 | +13,366 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 10,793 | +10,793 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 16,347 | 26,024 | +9,677 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 40,470 | 48,484 | +8,014 | 0.02 | 0.02 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,787 | +4,787 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 5,143 | 9,524 | +4,381 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 617,173 | 621,111 | +3,938 | 1.72 | 1.21 | -0.50 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 8,585 | 11,501 | +2,916 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 2,448 | +2,448 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,919 | 68,219 | +2,300 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 42,972 | 44,773 | +1,801 | 0.01 | 0.01 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,429 | +1,429 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 8,263 | 9,447 | +1,184 | 0.06 | 0.06 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 29,861 | 30,590 | +729 | 0.00 | 0.00 | -0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 3.13 | 2.01 | -1.12 | hold |
| PERCEPTIVE ADVISORS LLC | 3,491,500 | 3,491,500 | 0 | 1.36 | 0.82 | -0.54 | hold |
| Rock Springs Capital Management LP | 1,875,466 | 1,875,466 | 0 | 0.58 | 0.49 | -0.09 | hold |
| Samsara BioCapital, LLC | 396,000 | 396,000 | 0 | 1.40 | 0.65 | -0.75 | hold |
| Affinity Asset Advisors, LLC | 200,000 | 200,000 | 0 | 0.76 | 0.42 | -0.34 | hold |
| Ikarian Capital, LLC | 49,031 | 49,031 | 0 | 0.21 | 0.14 | -0.07 | hold |
| Texas Capital Bank Wealth Management Services Inc | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 701 | 701 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,877 | 29,877 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 1,716 | 1,696 | -20 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 668 | 511 | -157 | 0.00 | 0.00 | -0.00 | sell |
| Parkside Financial Bank & Trust | 780 | 0 | -780 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 85,588 | 84,307 | -1,281 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 31,948 | 30,100 | -1,848 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 2,158 | 0 | -2,158 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 2,188 | 0 | -2,188 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,687 | 3,323 | -2,364 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 4,843 | 0 | -4,843 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 302,830 | 291,571 | -11,259 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 23,087 | 8,202 | -14,885 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 15,513 | 0 | -15,513 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 26,748 | 10,653 | -16,095 | 0.00 | 0.00 | -0.00 | sell |
| Artisan Partners Limited Partnership | 705,214 | 688,950 | -16,264 | 0.01 | 0.01 | -0.00 | sell |
| Tri Locum Partners LP | 304,974 | 275,482 | -29,492 | 1.13 | 1.42 | +0.29 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 50,400 | 13,761 | -36,639 | 0.02 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 59,948 | 809 | -59,139 | 0.01 | 0.00 | -0.01 | sell |
| MORGAN STANLEY | 236,008 | 153,293 | -82,715 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 116,602 | 0 | -116,602 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 121,499 | 0 | -121,499 | 0.02 | 0.00 | -0.02 | sell |
| MARSHALL WACE, LLP | 134,736 | 0 | -134,736 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 513,773 | 281,284 | -232,489 | 0.02 | 0.01 | -0.01 | sell |
| Verition Fund Management LLC | 256,817 | 0 | -256,817 | 0.04 | 0.00 | -0.04 | sell |
| Sofinnova Investments, Inc. | 3,251,509 | 2,969,039 | -282,470 | 2.62 | 1.75 | -0.86 | sell |
| Point72 Asset Management, L.P. | 351,330 | 67,015 | -284,315 | 0.01 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 794,060 | 470,285 | -323,775 | 0.06 | 0.03 | -0.03 | sell |
| Woodline Partners LP | 2,400,000 | 2,070,083 | -329,917 | 0.33 | 0.24 | -0.09 | sell |
| AMERIPRISE FINANCIAL INC | 332,243 | 0 | -332,243 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 1,920,636 | 1,413,956 | -506,680 | 2.82 | 1.49 | -1.33 | sell |
| Logos Global Management LP | 1,050,000 | 0 | -1,050,000 | 1.73 | 0.00 | -1.73 | sell |