| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 5,065,277 | +5,065,277 | 0.00 | 1.33 | +1.33 | buy |
| T. Rowe Price Investment Management, Inc. | 7,379,636 | 10,604,777 | +3,225,141 | 0.05 | 0.05 | -0.00 | buy |
| Vestal Point Capital, LP | 3,750,000 | 6,275,000 | +2,525,000 | 3.38 | 2.65 | -0.73 | buy |
| MORGAN STANLEY | 163,571 | 2,438,046 | +2,274,475 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 114,265 | 2,380,406 | +2,266,141 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,647,565 | 3,503,965 | +1,856,400 | 0.53 | 0.74 | +0.21 | buy |
| Paradigm Biocapital Advisors LP | 3,904,862 | 5,414,409 | +1,509,547 | 1.56 | 1.34 | -0.22 | buy |
| PERCEPTIVE ADVISORS LLC | 8,086,159 | 9,383,456 | +1,297,297 | 1.98 | 1.86 | -0.12 | buy |
| ORBIMED ADVISORS LLC | 2,006,381 | 3,087,462 | +1,081,081 | 0.42 | 0.46 | +0.04 | buy |
| BAKER BROS. ADVISORS LP | 6,443,398 | 7,275,830 | +832,432 | 0.76 | 0.55 | -0.21 | buy |
| Frazier Life Sciences Management, L.P. | 1,354,711 | 2,147,911 | +793,200 | 0.62 | 0.63 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 9,681,183 | 10,417,892 | +736,709 | 0.02 | 0.01 | -0.01 | buy |
| UBS Group AG | 0 | 270,449 | +270,449 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 35,394 | 278,382 | +242,988 | 0.01 | 0.03 | +0.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 721,111 | 921,111 | +200,000 | 1.35 | 1.21 | -0.14 | buy |
| Qube Research & Technologies Ltd | 0 | 185,960 | +185,960 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 165,000 | +165,000 | 0.00 | 0.21 | +0.21 | buy |
| LAZARD ASSET MANAGEMENT LLC | 87 | 162,504 | +162,417 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 156,686 | +156,686 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 280,447 | 427,994 | +147,547 | 0.00 | 0.00 | -0.00 | buy |
| Zimmer Partners, LP | 280,000 | 405,000 | +125,000 | 0.06 | 0.05 | -0.01 | buy |
| Aberdeen Group plc | 232,900 | 347,379 | +114,479 | 0.00 | 0.00 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 203,614 | 311,722 | +108,108 | 0.11 | 0.13 | +0.03 | buy |
| DAFNA Capital Management LLC | 145,000 | 245,000 | +100,000 | 0.39 | 0.44 | +0.05 | buy |
| SIMPLEX TRADING, LLC | 0 | 97,085 | +97,085 | 0.00 | 0.02 | +0.02 | buy |
| WASATCH ADVISORS LP | 872,511 | 957,052 | +84,541 | 0.05 | 0.03 | -0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 84,166 | +84,166 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 67,369 | +67,369 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 57,487 | +57,487 | 0.00 | 0.00 | +0.00 | buy |
| Aquilo Capital Management, LLC | 333,502 | 373,902 | +40,400 | 4.28 | 4.55 | +0.27 | buy |
| ALGERT GLOBAL LLC | 21,458 | 58,596 | +37,138 | 0.01 | 0.01 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 29,624 | +29,624 | 0.00 | 0.01 | +0.01 | buy |
| Aristides Capital LLC | 0 | 28,900 | +28,900 | 0.00 | 0.06 | +0.06 | buy |
| Graham Capital Management, L.P. | 0 | 18,338 | +18,338 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 14,210 | +14,210 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 35,922 | 47,226 | +11,304 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 24,462 | 31,462 | +7,000 | 0.04 | 0.05 | +0.01 | buy |
| Forefront Analytics, LLC | 11,180 | 15,911 | +4,731 | 0.06 | 0.05 | -0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 18,224 | 22,701 | +4,477 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,115 | 9,594 | +2,479 | 0.04 | 0.03 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 110,007 | 111,267 | +1,260 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 1,365 | 1,861 | +496 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 29,877 | 30,364 | +487 | 0.00 | 0.00 | -0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 64 | +64 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 1.29 | 0.59 | -0.71 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,750,000 | 1,750,000 | 0 | 0.23 | 0.17 | -0.06 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.01 | 0.01 | -0.01 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 13,155 | 13,155 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 104 | 104 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 198,000 | 198,000 | 0 | 0.43 | 0.19 | -0.24 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,587 | 27,587 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| American Capital Advisory, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 204 | 126 | -78 | 0.00 | 0.00 | -0.00 | sell |
| SUMMIT SECURITIES GROUP LLC | 125 | 0 | -125 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 200 | 0 | -200 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 36,011 | 35,652 | -359 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 1,434 | 776 | -658 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,606 | 0 | -3,606 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 25,439 | 15,538 | -9,901 | 0.14 | 0.06 | -0.08 | sell |
| Texas Capital Bank Wealth Management Services Inc | 10,000 | 0 | -10,000 | 0.01 | 0.00 | -0.01 | sell |
| Quarry LP | 11,000 | 0 | -11,000 | 0.04 | 0.00 | -0.04 | sell |
| JPMORGAN CHASE & CO | 299,066 | 286,769 | -12,297 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 12,729 | 0 | -12,729 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 13,516 | 0 | -13,516 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,829 | 0 | -13,829 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,116 | 0 | -14,116 | 0.01 | 0.00 | -0.01 | sell |
| Campbell & CO Investment Adviser LLC | 14,798 | 0 | -14,798 | 0.01 | 0.00 | -0.01 | sell |
| Artisan Partners Limited Partnership | 661,317 | 645,607 | -15,710 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 703,655 | 686,181 | -17,474 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 18,900 | 0 | -18,900 | 0.02 | 0.00 | -0.02 | sell |
| Trexquant Investment LP | 23,721 | 0 | -23,721 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 24,282 | 0 | -24,282 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 26,100 | 0 | -26,100 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 33,600 | 0 | -33,600 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 106,669 | 70,324 | -36,345 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 63,647 | 24,734 | -38,913 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 59,800 | 18,700 | -41,100 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 386,100 | 343,206 | -42,894 | 0.36 | 0.18 | -0.19 | sell |
| HighVista Strategies LLC | 45,544 | 0 | -45,544 | 0.18 | 0.00 | -0.18 | sell |
| Nantahala Capital Management, LLC | 625,659 | 578,856 | -46,803 | 0.60 | 0.29 | -0.31 | sell |
| Ikarian Capital, LLC | 49,415 | 0 | -49,415 | 0.18 | 0.00 | -0.18 | sell |
| 683 Capital Management, LLC | 700,000 | 650,000 | -50,000 | 0.81 | 0.45 | -0.36 | sell |
| BIT Capital GmbH | 51,102 | 0 | -51,102 | 0.06 | 0.00 | -0.06 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 164,766 | 93,279 | -71,487 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 225,202 | 152,510 | -72,692 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 359,244 | 254,282 | -104,962 | 0.00 | 0.00 | -0.00 | sell |
| Crestline Management, LP | 136,721 | 0 | -136,721 | 0.09 | 0.00 | -0.09 | sell |
| Focus Partners Wealth | 215,449 | 0 | -215,449 | 0.01 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 250,000 | 0 | -250,000 | 0.44 | 0.00 | -0.44 | sell |
| Walleye Capital LLC | 282,193 | 0 | -282,193 | 0.03 | 0.00 | -0.03 | sell |
| ExodusPoint Capital Management, LP | 451,476 | 62,077 | -389,399 | 0.05 | 0.00 | -0.05 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 721,252 | 330,002 | -391,250 | 0.01 | 0.00 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 449,735 | 0 | -449,735 | 1.54 | 0.00 | -1.54 | sell |
| Woodline Partners LP | 2,501,962 | 2,034,224 | -467,738 | 0.24 | 0.10 | -0.14 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,494,502 | 2,461,592 | -1,032,910 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,920,843 | 328,765 | -1,592,078 | 0.02 | 0.00 | -0.02 | sell |
| RTW INVESTMENTS, LP | 10,000,000 | 6,540,540 | -3,459,460 | 1.65 | 0.70 | -0.95 | sell |