| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 7,379,636 | 10,604,777 | +3,225,141 | 0.05 | 0.05 | -0.00 | buy |
| Vestal Point Capital, LP | 3,750,000 | 6,275,000 | +2,525,000 | 3.38 | 2.65 | -0.73 | buy |
| BRAIDWELL LP | 1,647,565 | 3,503,965 | +1,856,400 | 0.53 | 0.74 | +0.21 | buy |
| Paradigm Biocapital Advisors LP | 3,904,862 | 5,414,409 | +1,509,547 | 1.56 | 1.34 | -0.22 | buy |
| PERCEPTIVE ADVISORS LLC | 8,086,159 | 9,383,456 | +1,297,297 | 1.95 | 1.84 | -0.11 | buy |
| ORBIMED ADVISORS LLC | 2,006,381 | 3,087,462 | +1,081,081 | 0.42 | 0.46 | +0.04 | buy |
| BAKER BROS. ADVISORS LP | 6,443,398 | 7,275,830 | +832,432 | 0.76 | 0.55 | -0.21 | buy |
| Frazier Life Sciences Management, L.P. | 1,354,711 | 2,147,911 | +793,200 | 0.62 | 0.63 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 721,111 | 921,111 | +200,000 | 1.31 | 1.18 | -0.13 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 280,447 | 427,994 | +147,547 | 0.00 | 0.00 | -0.00 | buy |
| Zimmer Partners, LP | 280,000 | 405,000 | +125,000 | 0.06 | 0.05 | -0.01 | buy |
| Aberdeen Group plc | 232,900 | 347,379 | +114,479 | 0.00 | 0.00 | -0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 203,614 | 311,722 | +108,108 | 0.11 | 0.13 | +0.03 | buy |
| DAFNA Capital Management LLC | 145,000 | 245,000 | +100,000 | 0.39 | 0.44 | +0.05 | buy |
| WASATCH ADVISORS LP | 872,511 | 957,052 | +84,541 | 0.05 | 0.03 | -0.02 | buy |
| Aquilo Capital Management, LLC | 333,502 | 373,902 | +40,400 | 4.28 | 4.55 | +0.27 | buy |
| Pale Fire Capital SE | 24,462 | 31,462 | +7,000 | 0.04 | 0.05 | +0.01 | buy |
| Forefront Analytics, LLC | 11,180 | 15,911 | +4,731 | 0.06 | 0.05 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 7,115 | 9,594 | +2,479 | 0.04 | 0.03 | -0.01 | buy |
| ARISTEIA CAPITAL, L.L.C. | 832,328 | 831,531 | -797 | 0.07 | 0.01 | -0.06 | sell |
| Corton Capital Inc. | 25,439 | 15,538 | -9,901 | 0.14 | 0.06 | -0.08 | sell |
| Artisan Partners Limited Partnership | 661,317 | 645,607 | -15,710 | 0.01 | 0.01 | -0.00 | sell |
| Sofinnova Investments, Inc. | 386,100 | 343,206 | -42,894 | 0.35 | 0.18 | -0.17 | sell |
| Nantahala Capital Management, LLC | 625,659 | 578,856 | -46,803 | 0.36 | 0.18 | -0.18 | sell |
| 683 Capital Management, LLC | 700,000 | 650,000 | -50,000 | 0.61 | 0.29 | -0.32 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 721,252 | 330,002 | -391,250 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 2,501,962 | 2,034,224 | -467,738 | 0.24 | 0.10 | -0.14 | sell |
| RTW INVESTMENTS, LP | 10,000,000 | 6,540,540 | -3,459,460 | 1.65 | 0.70 | -0.95 | sell |