| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Jefferies Financial Group Inc. | 1,194,915 | 5,059,551 | +3,864,636 | 0.09 | 0.44 | +0.34 | buy |
| RTW INVESTMENTS, LP | 8,815,617 | 11,433,354 | +2,617,737 | 0.93 | 1.20 | +0.28 | buy |
| T. Rowe Price Investment Management, Inc. | 19,383,169 | 21,459,156 | +2,075,987 | 0.10 | 0.14 | +0.04 | buy |
| Point72 Asset Management, L.P. | 118,189 | 1,754,181 | +1,635,992 | 0.00 | 0.03 | +0.03 | buy |
| Sofinnova Investments, Inc. | 2,227,837 | 3,435,542 | +1,207,705 | 1.16 | 1.56 | +0.39 | buy |
| CITADEL ADVISORS LLC | 603,155 | 1,714,961 | +1,111,806 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 9,383,456 | 10,383,456 | +1,000,000 | 2.31 | 2.00 | -0.31 | buy |
| Lynx1 Capital Management LP | 0 | 921,950 | +921,950 | 0.00 | 1.96 | +1.96 | buy |
| STEMPOINT CAPITAL LP | 0 | 610,308 | +610,308 | 0.00 | 1.10 | +1.10 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 592,428 | +592,428 | 0.00 | 0.01 | +0.01 | buy |
| Caption Management, LLC | 0 | 550,891 | +550,891 | 0.00 | 0.26 | +0.26 | buy |
| Alyeska Investment Group, L.P. | 300,000 | 789,163 | +489,163 | 0.01 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 583,105 | 861,105 | +278,000 | 1.18 | 1.89 | +0.71 | buy |
| STATE STREET CORP | 218,501 | 444,658 | +226,157 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 349,379 | 563,463 | +214,084 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 208,456 | +208,456 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 45,202 | 206,568 | +161,366 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 160,336 | +160,336 | 0.00 | 0.95 | +0.95 | buy |
| Burkehill Global Management, LP | 0 | 150,000 | +150,000 | 0.00 | 0.10 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 190,759 | 323,023 | +132,264 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,512,241 | 1,635,231 | +122,990 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 383,804 | 500,724 | +116,920 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 110,082 | +110,082 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 104,929 | +104,929 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 68,732 | 134,763 | +66,031 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 56,367 | +56,367 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 54,720 | +54,720 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 44,466 | 96,784 | +52,318 | 0.02 | 0.03 | +0.02 | buy |
| Jump Financial, LLC | 0 | 50,868 | +50,868 | 0.00 | 0.01 | +0.01 | buy |
| Longaeva Partners L.P. | 0 | 44,601 | +44,601 | 0.00 | 0.06 | +0.06 | buy |
| DAFNA Capital Management LLC | 235,000 | 261,138 | +26,138 | 0.49 | 0.64 | +0.14 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 724,807 | 748,035 | +23,228 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 20,220 | +20,220 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 19,630 | +19,630 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 12,307 | +12,307 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 135,957 | 146,972 | +11,015 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,800 | 55,300 | +8,500 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 8,001 | +8,001 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 18,532 | 26,497 | +7,965 | 0.05 | 0.08 | +0.03 | buy |
| BARCLAYS PLC | 25,311 | 28,185 | +2,874 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 47,635 | 49,374 | +1,739 | 0.00 | 0.01 | +0.00 | buy |
| Farther Finance Advisors, LLC | 335 | 528 | +193 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 16,278 | 16,402 | +124 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | 697,431 | 0 | 0.86 | 1.04 | +0.18 | hold |
| BAKER BROS. ADVISORS LP | 12,094,094 | 12,094,094 | 0 | 0.74 | 0.74 | -0.00 | hold |
| J. Goldman & Co LP | 22,788 | 22,788 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MYDA Advisors LLC | 120,000 | 120,000 | 0 | 0.31 | 0.35 | +0.05 | hold |
| NewEdge Advisors, LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 29,987 | 29,987 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mariner, LLC | 13,550 | 13,405 | -145 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 11,442 | 11,234 | -208 | 0.01 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 49,396 | 48,569 | -827 | 0.09 | 0.07 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 122,510 | 116,646 | -5,864 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 154,753 | 147,328 | -7,425 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 214,561 | 203,449 | -11,112 | 0.00 | 0.00 | +0.00 | sell |
| INSIGNEO ADVISORY SERVICES, LLC | 12,062 | 0 | -12,062 | 0.01 | 0.00 | -0.01 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 31,958 | 16,955 | -15,003 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 34,270 | 16,272 | -17,998 | 0.03 | 0.02 | -0.01 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 427,994 | 402,352 | -25,642 | 0.00 | 0.00 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 49,947 | 0 | -49,947 | 0.02 | 0.00 | -0.02 | sell |
| HRT FINANCIAL LP | 67,395 | 0 | -67,395 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 789,446 | 714,569 | -74,877 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 2,205,321 | 2,089,796 | -115,525 | 0.00 | 0.00 | +0.00 | sell |
| WASATCH ADVISORS LP | 718,897 | 515,128 | -203,769 | 0.03 | 0.03 | -0.00 | sell |
| BlackRock, Inc. | 236,523 | 25,554 | -210,969 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 6,350,000 | 6,125,000 | -225,000 | 2.45 | 2.36 | -0.10 | sell |
| ORBIMED ADVISORS LLC | 466,601 | 0 | -466,601 | 0.10 | 0.00 | -0.10 | sell |
| SECTORAL ASSET MANAGEMENT INC | 560,494 | 63,015 | -497,479 | 2.95 | 0.53 | -2.42 | sell |
| 683 Capital Management, LLC | 520,000 | 0 | -520,000 | 0.40 | 0.00 | -0.40 | sell |
| MILLENNIUM MANAGEMENT LLC | 721,866 | 83,122 | -638,744 | 0.00 | 0.00 | -0.00 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,030,129 | 11,190,129 | -840,000 | 3.11 | 2.93 | -0.18 | sell |
| Woodline Partners LP | 1,841,602 | 1,000,597 | -841,005 | 0.07 | 0.04 | -0.03 | sell |
| TORONTO DOMINION BANK | 5,122,063 | 0 | -5,122,063 | 0.08 | 0.00 | -0.08 | sell |