| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 8,815,617 | 11,433,354 | +2,617,737 | 0.93 | 1.20 | +0.28 | buy |
| T. Rowe Price Investment Management, Inc. | 19,383,169 | 21,459,156 | +2,075,987 | 0.10 | 0.14 | +0.04 | buy |
| Sofinnova Investments, Inc. | 2,227,837 | 3,435,542 | +1,207,705 | 1.04 | 1.56 | +0.52 | buy |
| PERCEPTIVE ADVISORS LLC | 9,383,456 | 10,383,456 | +1,000,000 | 2.31 | 1.94 | -0.37 | buy |
| Alyeska Investment Group, L.P. | 300,000 | 789,163 | +489,163 | 0.01 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 583,105 | 861,105 | +278,000 | 1.05 | 1.75 | +0.70 | buy |
| TD ASSET MANAGEMENT INC | 383,804 | 500,724 | +116,920 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 44,466 | 96,784 | +52,318 | 0.02 | 0.03 | +0.01 | buy |
| DAFNA Capital Management LLC | 235,000 | 261,138 | +26,138 | 0.49 | 0.64 | +0.14 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 427,994 | 402,352 | +25,642 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 18,532 | 26,497 | +7,965 | 0.05 | 0.08 | +0.03 | buy |
| Ikarian Capital, LLC | 49,396 | 48,569 | -827 | 0.09 | 0.07 | -0.02 | sell |
| Pale Fire Capital SE | 34,270 | 16,272 | -17,998 | 0.03 | 0.02 | -0.01 | sell |
| Aberdeen Group plc | 789,446 | 714,569 | -74,877 | 0.01 | 0.01 | +0.00 | sell |
| WASATCH ADVISORS LP | 718,897 | 515,128 | -203,769 | 0.03 | 0.03 | -0.00 | sell |
| Vestal Point Capital, LP | 6,350,000 | 6,125,000 | -225,000 | 2.45 | 2.36 | -0.10 | sell |
| SECTORAL ASSET MANAGEMENT INC | 560,494 | 63,015 | -497,479 | 2.95 | 0.53 | -2.42 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 12,030,129 | 11,190,129 | -840,000 | 2.62 | 2.41 | -0.22 | sell |