| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,655,000 | 2,610,000 | +955,000 | 2.61 | 2.41 | -0.20 | buy |
| Redmile Group, LLC | 3,659,264 | 4,326,509 | +667,245 | 1.95 | 1.77 | -0.18 | buy |
| MARSHALL WACE, LLP | 11,569 | 121,546 | +109,977 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 106,356 | +106,356 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 90,743 | 157,002 | +66,259 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,502,409 | 1,566,464 | +64,055 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 60,190 | +60,190 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 59,186 | +59,186 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 54,366 | +54,366 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 501,496 | 553,867 | +52,371 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 7,472,821 | 7,522,812 | +49,991 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 80,688 | 127,037 | +46,349 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 44,200 | +44,200 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,743 | 43,507 | +38,764 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 0 | 33,156 | +33,156 | 0.00 | 0.04 | +0.04 | buy |
| AlphaQuest LLC | 0 | 25,032 | +25,032 | 0.00 | 0.05 | +0.05 | buy |
| Trexquant Investment LP | 0 | 20,990 | +20,990 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 20,240 | +20,240 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 585,034 | 604,714 | +19,680 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,437 | 22,797 | +18,360 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 13,309 | 29,084 | +15,775 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 43,598 | 59,195 | +15,597 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,289 | 17,186 | +14,897 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 48,059 | 60,119 | +12,060 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,999 | +11,999 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 11,535 | +11,535 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,911 | +10,911 | 0.00 | 0.02 | +0.02 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 10,440 | +10,440 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,289 | +10,289 | 0.00 | 0.01 | +0.01 | buy |
| Forefront Analytics, LLC | 0 | 10,261 | +10,261 | 0.00 | 0.06 | +0.06 | buy |
| FRANKLIN RESOURCES INC | 0 | 10,047 | +10,047 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,196 | 29,663 | +8,467 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 196,536 | 201,362 | +4,826 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,762 | 9,587 | +3,825 | 0.02 | 0.01 | -0.00 | buy |
| MPM BioImpact LLC | 1,264,759 | 1,268,471 | +3,712 | 4.41 | 2.27 | -2.13 | buy |
| EntryPoint Capital, LLC | 0 | 2,847 | +2,847 | 0.00 | 0.03 | +0.03 | buy |
| CANADA LIFE ASSURANCE Co | 0 | 2,379 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,233,107 | 1,235,215 | +2,108 | 0.02 | 0.01 | -0.01 | buy |
| RHUMBLINE ADVISERS | 48,154 | 49,860 | +1,706 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 208,164 | 209,759 | +1,595 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 243,840 | 245,212 | +1,372 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,296 | 9,324 | +1,028 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 11,122 | 11,488 | +366 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 10,702 | 10,937 | +235 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,487 | 12,646 | +159 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 392 | 402 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,790 | 2,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOURGEON CAPITAL MANAGEMENT LLC | 19,570 | 19,570 | 0 | 0.06 | 0.04 | -0.02 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 160,000 | 160,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 41,000 | 41,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 14,561 | 14,561 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 3,142,079 | 3,142,079 | 0 | 2.24 | 1.54 | -0.70 | hold |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 4,220,048 | 4,220,048 | 0 | 5.14 | 3.70 | -1.45 | hold |
| Aberdeen Group plc | 66,211 | 66,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| venBio Partners LLC | 9,699,925 | 9,699,925 | 0 | 21.65 | 38.37 | +16.72 | hold |
| Nan Fung Group Holdings Ltd | 41,950 | 41,950 | 0 | 0.39 | 0.43 | +0.04 | hold |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Red Tortoise LLC | 340 | 340 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 90,957 | 90,957 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Private Wealth Management Group, LLC | 98 | 98 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,579 | 1,579 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 456 | 456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 329 | 204 | -125 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 24,946 | 24,806 | -140 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,398 | 13,000 | -398 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 7,019 | 6,566 | -453 | 0.07 | 0.04 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 65,921 | 65,455 | -466 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,907 | 1,317 | -590 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,871 | 897 | -974 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 40,290 | 38,790 | -1,500 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 30,988 | 29,074 | -1,914 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,561 | 4,746 | -2,815 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 7,880 | 3,514 | -4,366 | 0.00 | 0.00 | -0.00 | sell |
| Quantbot Technologies LP | 5,600 | 0 | -5,600 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 47,583 | 41,897 | -5,686 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 42,109 | 36,195 | -5,914 | 0.01 | 0.01 | -0.00 | sell |
| SG Americas Securities, LLC | 30,348 | 23,906 | -6,442 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 86,306 | 79,767 | -6,539 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 30,391 | 23,366 | -7,025 | 0.01 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 8,434 | 0 | -8,434 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 10,708 | 0 | -10,708 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 33,500 | 20,000 | -13,500 | 0.01 | 0.00 | -0.01 | sell |
| Dynamic Technology Lab Private Ltd | 14,389 | 0 | -14,389 | 0.02 | 0.00 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,515 | 23,702 | -15,813 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 44,637 | 28,635 | -16,002 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 64,756 | 47,155 | -17,601 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 17,793 | 0 | -17,793 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 70,400 | 49,000 | -21,400 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Trading LLC | 23,032 | 0 | -23,032 | 0.01 | 0.00 | -0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 123,420 | 98,960 | -24,460 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 270,500 | 234,100 | -36,400 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 77,830 | 38,241 | -39,589 | 0.02 | 0.00 | -0.01 | sell |