| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 13,011,849 | +13,011,849 | 0.00 | 0.28 | +0.28 | buy |
| TCG Crossover Management, LLC | 0 | 13,011,849 | +13,011,849 | 0.00 | 0.75 | +0.75 | buy |
| Blackstone Inc. | 0 | 5,826,544 | +5,826,544 | 0.00 | 0.05 | +0.05 | buy |
| Redmile Group, LLC | 3,264,718 | 7,964,188 | +4,699,470 | 0.27 | 1.06 | +0.79 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,422,882 | 5,734,620 | +4,311,738 | 0.01 | 0.08 | +0.07 | buy |
| MARSHALL WACE, LLP | 26,376 | 3,757,216 | +3,730,840 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 0 | 3,184,713 | +3,184,713 | 0.00 | 0.53 | +0.53 | buy |
| venBio Partners LLC | 9,699,925 | 12,884,638 | +3,184,713 | 5.07 | 9.21 | +4.14 | buy |
| 5AM Venture Management, LLC | 0 | 3,057,325 | +3,057,325 | 0.00 | 1.70 | +1.70 | buy |
| ORBIMED ADVISORS LLC | 0 | 2,866,256 | +2,866,256 | 0.00 | 0.13 | +0.13 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 1,328,907 | +1,328,907 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 950,550 | +950,550 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 640,205 | 1,587,833 | +947,628 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 2,536,891 | 3,173,834 | +636,943 | 0.63 | 1.44 | +0.81 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 423,099 | 732,599 | +309,500 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 353,696 | 493,437 | +139,741 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 107,647 | +107,647 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 79,389 | +79,389 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 75,000 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 124,228 | 175,828 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 865,991 | 914,754 | +48,763 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 531,845 | 577,783 | +45,938 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 44,141 | +44,141 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 37,739 | +37,739 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 0 | 20,946 | +20,946 | 0.00 | 1.04 | +1.04 | buy |
| Point72 Asset Management, L.P. | 20,217 | 41,095 | +20,878 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,993 | +10,993 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 10,980 | +10,980 | 0.00 | 0.00 | +0.00 | buy |
| NINE MASTS CAPITAL Ltd | 15,475 | 20,623 | +5,148 | 0.00 | 0.01 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 905 | +905 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 37,992 | 37,997 | +5 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 76,072 | 76,072 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MONETA GROUP INVESTMENT ADVISORS LLC | 15,196 | 15,196 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Lido Advisors, LLC | 13,220 | 13,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IEQ CAPITAL, LLC | 92,233 | 92,233 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JSF Financial, LLC | 17,500 | 17,500 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Optiver Holding B.V. | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Abel Hall, LLC | 12,598 | 12,598 | 0 | 0.00 | 0.01 | +0.00 | hold |
| BARCLAYS PLC | 10,515 | 10,515 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 12,986 | 12,986 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 10,105 | 10,105 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,106 | 1,106 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF NOVA SCOTIA | 105,858 | 105,858 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 480 | 466 | -14 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 412 | 14 | -398 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 518 | 0 | -518 | 0.00 | 0.00 | -0.00 | sell |
| HC Advisors, LLC | 23,900 | 22,900 | -1,000 | 0.02 | 0.03 | +0.01 | sell |
| BlackRock, Inc. | 450,430 | 447,799 | -2,631 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,142 | 0 | -3,142 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 3,553 | 0 | -3,553 | 0.00 | 0.00 | -0.00 | sell |
| Callan Family Office, LLC | 28,308 | 22,419 | -5,889 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 149,097 | 136,964 | -12,133 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 13,702 | 0 | -13,702 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,102 | 0 | -15,102 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 92,654 | 68,987 | -23,667 | 0.01 | 0.01 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 41,000 | 0 | -41,000 | 0.00 | 0.00 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 41,950 | 0 | -41,950 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,374,273 | 1,101,025 | -273,248 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 474,781 | 0 | -474,781 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 710,400 | 0 | -710,400 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,204,619 | 1,988,559 | -1,216,060 | 0.00 | 0.00 | +0.00 | sell |