| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| venBio Partners LLC | 9,699,925 | 9,699,925 | 0 | 38.37 | 25.26 | -13.10 | hold |
| FMR LLC | 7,522,812 | 7,814,996 | +292,184 | 0.01 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 4,220,048 | 4,220,048 | 0 | 3.70 | 2.35 | -1.35 | hold |
| Redmile Group, LLC | 4,326,509 | 4,036,451 | -290,058 | 1.77 | 1.47 | -0.30 | sell |
| Vestal Point Capital, LP | 2,610,000 | 3,600,000 | +990,000 | 2.41 | 1.62 | -0.79 | buy |
| MPM BioImpact LLC | 1,268,471 | 2,180,864 | +912,393 | 2.27 | 2.04 | -0.23 | buy |
| ORBIMED ADVISORS LLC | 2,717,970 | 1,894,462 | -823,508 | 0.56 | 0.23 | -0.33 | sell |
| VANGUARD GROUP INC | 1,566,464 | 1,727,248 | +160,784 | 0.00 | 0.00 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,575,605 | +1,575,605 | 0.00 | 0.36 | +0.36 | buy |
| MILLENNIUM MANAGEMENT LLC | 60,190 | 1,325,196 | +1,265,006 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 553,867 | 705,547 | +151,680 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 604,714 | 700,406 | +95,692 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 343,137 | 673,358 | +330,221 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 121,546 | 635,679 | +514,133 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 234,100 | 438,200 | +204,100 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 0 | 396,966 | +396,966 | 0.00 | 0.58 | +0.58 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 307,529 | +307,529 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 304,100 | +304,100 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 65,455 | 292,226 | +226,771 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 245,212 | 244,551 | -661 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 209,759 | 236,020 | +26,261 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 232,022 | +232,022 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 157,002 | 215,252 | +58,250 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 199,441 | +199,441 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,037 | 145,717 | +18,680 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 24,806 | 140,000 | +115,194 | 0.01 | 0.02 | +0.01 | buy |
| Walleye Capital LLC | 38,241 | 109,762 | +71,521 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 79,767 | 104,966 | +25,199 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 59,195 | 78,100 | +18,905 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 2,847 | 76,415 | +73,568 | 0.03 | 0.21 | +0.19 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 54,366 | 75,120 | +20,754 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 90,957 | 73,468 | -17,489 | 0.02 | 0.02 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 38,790 | 71,730 | +32,940 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,235,215 | 68,511 | -1,166,704 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 10,000 | 67,600 | +57,600 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 66,211 | 66,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Inspire Investing, LLC | 33,156 | 58,707 | +25,551 | 0.04 | 0.04 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,860 | 55,220 | +5,360 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 44,200 | 49,400 | +5,200 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 44,149 | +44,149 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 41,950 | 41,950 | 0 | 0.43 | 0.27 | -0.16 | hold |
| ALGERT GLOBAL LLC | 0 | 41,215 | +41,215 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 47,155 | 41,010 | -6,145 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 41,000 | 41,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 50,341 | 34,543 | -15,798 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 32,571 | +32,571 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 31,419 | +31,419 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 29,084 | 27,014 | -2,070 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 17,186 | 25,887 | +8,701 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,797 | 25,254 | +2,457 | 0.00 | 0.00 | -0.00 | buy |
| LMR Partners LLP | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,702 | 24,561 | +859 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 23,942 | +23,942 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,663 | 23,685 | -5,978 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 0 | 22,172 | +22,172 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 21,823 | +21,823 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 25,032 | 20,781 | -4,251 | 0.05 | 0.02 | -0.03 | sell |
| SG Americas Securities, LLC | 23,906 | 20,506 | -3,400 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 18,940 | +18,940 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,999 | 18,079 | +6,080 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 28,635 | 17,317 | -11,318 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 16,402 | +16,402 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 14,561 | 16,140 | +1,579 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,119 | 13,662 | -46,457 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 12,600 | +12,600 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,646 | 12,522 | -124 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,215 | +11,215 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 10,780 | +10,780 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 6,566 | 10,726 | +4,160 | 0.04 | 0.03 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 232,769 | 10,622 | -222,147 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 9,324 | 10,575 | +1,251 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 11,488 | 10,434 | -1,054 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 10,440 | 10,292 | -148 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 0 | 10,290 | +10,290 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 20,240 | 10,098 | -10,142 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 43,507 | 8,292 | -35,215 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,746 | 7,579 | +2,833 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 6,600 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,317 | 6,517 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,587 | 6,122 | -3,465 | 0.01 | 0.01 | -0.01 | sell |
| STRS OHIO | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,790 | 2,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 2,379 | 2,379 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 0 | 2,331 | +2,331 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 201,362 | 2,329 | -199,033 | 0.01 | 0.00 | -0.01 | sell |
| Point72 (DIFC) Ltd | 0 | 1,963 | +1,963 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 10,937 | 1,555 | -9,382 | 0.00 | 0.00 | -0.00 | sell |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 897 | 897 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Smartleaf Asset Management LLC | 0 | 631 | +631 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 402 | 606 | +204 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 571 | +571 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 456 | 411 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 204 | 204 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Private Wealth Management Group, LLC | 98 | 98 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 0 | 85 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 79 | 79 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 21 | 12 | -9 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |