| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 447,799 | 7,399,530 | +6,951,731 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 5,744,757 | +5,744,757 | 0.00 | 1.32 | +1.32 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 493,437 | 2,787,809 | +2,294,372 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 175,828 | 1,498,905 | +1,323,077 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 1,044,728 | +1,044,728 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 136,964 | 935,669 | +798,705 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 5,826,544 | 6,593,543 | +766,999 | 0.05 | 0.04 | -0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 750,000 | +750,000 | 0.00 | 0.09 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 742,331 | +742,331 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,587,833 | 2,178,176 | +590,343 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 533,660 | +533,660 | 0.00 | 0.05 | +0.05 | buy |
| GSA CAPITAL PARTNERS LLP | 68,987 | 413,545 | +344,558 | 0.01 | 0.05 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 5,734,620 | 6,025,240 | +290,620 | 0.08 | 0.07 | -0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 241,113 | +241,113 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 241,113 | +241,113 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 238,447 | +238,447 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 219,382 | +219,382 | 0.00 | 0.04 | +0.04 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,101,025 | 1,313,490 | +212,465 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 76,072 | 226,072 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 0 | 143,645 | +143,645 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 10,980 | 149,923 | +138,943 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 107,902 | +107,902 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 107,428 | +107,428 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 99,926 | +99,926 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 89,779 | +89,779 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 92,233 | 175,382 | +83,149 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 64,959 | +64,959 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 17 | 50,635 | +50,618 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 49,682 | +49,682 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 46,869 | +46,869 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 40,553 | +40,553 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 37,739 | 74,821 | +37,082 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 33,100 | +33,100 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 31,822 | +31,822 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 30,997 | +30,997 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 26,340 | +26,340 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 44,141 | 69,657 | +25,516 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 25,507 | +25,507 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 10,515 | 32,884 | +22,369 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 21,461 | +21,461 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 21,434 | +21,434 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,424 | +19,424 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 18,451 | +18,451 | 0.00 | 0.00 | +0.00 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 18,095 | +18,095 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 16,385 | +16,385 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 466 | 16,616 | +16,150 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 14,125 | +14,125 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 10,483 | +10,483 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 10,397 | +10,397 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 10,179 | +10,179 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 9,792 | +9,792 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 8,185 | +8,185 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,486 | +1,486 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 379 | +379 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 12,986 | 13,242 | +256 | 0.00 | 0.00 | -0.00 | buy |
| Abel Hall, LLC | 12,598 | 12,731 | +133 | 0.01 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 6 | 36 | +30 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 37,997 | 38,011 | +14 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 2,866,256 | 2,866,256 | 0 | 0.13 | 0.11 | -0.01 | hold |
| MONETA GROUP INVESTMENT ADVISORS LLC | 15,196 | 15,196 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 13,011,849 | 13,011,849 | 0 | 0.28 | 0.23 | -0.04 | hold |
| CAXTON CORP | 20,946 | 20,946 | 0 | 1.04 | 2.34 | +1.30 | hold |
| Lido Advisors, LLC | 13,220 | 13,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 3,184,713 | 3,184,713 | 0 | 0.53 | 0.60 | +0.07 | hold |
| EverSource Wealth Advisors, LLC | 905 | 905 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Beacon Pointe Advisors, LLC | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| venBio Partners LLC | 12,884,638 | 12,884,638 | 0 | 9.21 | 5.14 | -4.07 | hold |
| 5AM Venture Management, LLC | 3,057,325 | 3,057,325 | 0 | 1.70 | 2.20 | +0.50 | hold |
| JSF Financial, LLC | 17,500 | 17,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| HC Advisors, LLC | 22,900 | 22,900 | 0 | 0.03 | 0.03 | -0.00 | hold |
| SBI Securities Co., Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Callan Family Office, LLC | 22,419 | 22,419 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 10,105 | 10,105 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,106 | 1,106 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optiver Holding B.V. | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,993 | 0 | -10,993 | 0.00 | 0.00 | -0.00 | sell |
| NINE MASTS CAPITAL Ltd | 20,623 | 0 | -20,623 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 41,095 | 0 | -41,095 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 75,000 | 0 | -75,000 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 79,389 | 0 | -79,389 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF NOVA SCOTIA | 105,858 | 0 | -105,858 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 107,647 | 0 | -107,647 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 732,599 | 603,797 | -128,802 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 950,550 | 810,297 | -140,253 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 3,173,834 | 2,938,431 | -235,403 | 1.44 | 1.46 | +0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,988,559 | 1,543,594 | -444,965 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 914,754 | 462,943 | -451,811 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 7,964,188 | 7,392,504 | -571,684 | 1.06 | 1.03 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 577,783 | 0 | -577,783 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 3,757,216 | 3,071,496 | -685,720 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,328,907 | 0 | -1,328,907 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,000 | 0 | -2,000,000 | 0.01 | 0.00 | -0.01 | sell |
| TCG Crossover Management, LLC | 13,011,849 | 5,655,487 | -7,356,362 | 0.75 | 0.28 | -0.46 | sell |