| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | 4,204,735 | +4,204,735 | 0.00 | 0.55 | +0.55 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,325,196 | 2,002,374 | +677,178 | 0.01 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 571 | 457,717 | +457,146 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 67,600 | 500,500 | +432,900 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 426,424 | +426,424 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 292,226 | 660,059 | +367,833 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 317,322 | +317,322 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 18,940 | 290,396 | +271,456 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 257,779 | +257,779 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,180,864 | 2,409,862 | +228,998 | 2.04 | 0.66 | -1.39 | buy |
| Cubist Systematic Strategies, LLC | 199,441 | 383,512 | +184,071 | 0.02 | 0.01 | -0.01 | buy |
| VANGUARD GROUP INC | 1,727,248 | 1,884,573 | +157,325 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 137,983 | +137,983 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 41,010 | 174,623 | +133,613 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 109,762 | 230,875 | +121,113 | 0.01 | 0.00 | -0.00 | buy |
| Privium Fund Management B.V. | 396,966 | 509,059 | +112,093 | 0.58 | 0.23 | -0.35 | buy |
| Verition Fund Management LLC | 32,571 | 133,025 | +100,454 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 244,551 | 319,742 | +75,191 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 23,942 | 96,849 | +72,907 | 0.00 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 27,014 | 83,042 | +56,028 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 48,204 | +48,204 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 17,317 | 59,502 | +42,185 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 215,252 | 256,879 | +41,627 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 40,934 | +40,934 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 28,657 | +28,657 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 145,717 | 167,831 | +22,114 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 8,292 | 25,552 | +17,260 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 17,146 | +17,146 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 15,840 | +15,840 | 0.00 | 0.00 | +0.00 | buy |
| HC Advisors, LLC | 0 | 15,775 | +15,775 | 0.00 | 0.02 | +0.02 | buy |
| GROUP ONE TRADING LLC | 0 | 15,315 | +15,315 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 22,172 | 34,373 | +12,201 | 0.02 | 0.01 | -0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 11,527 | +11,527 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 18,079 | 28,506 | +10,427 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 9,369 | +9,369 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 16,402 | 24,003 | +7,601 | 0.02 | 0.01 | -0.01 | buy |
| SG Americas Securities, LLC | 20,506 | 27,394 | +6,888 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 10,434 | 16,283 | +5,849 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,016 | 18,077 | +5,061 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,122 | 10,130 | +4,008 | 0.01 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 10,780 | 13,919 | +3,139 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 34,543 | 37,646 | +3,103 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 1,963 | 3,599 | +1,636 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 11,215 | 12,813 | +1,598 | 0.00 | 0.00 | -0.00 | buy |
| Avior Wealth Management, LLC | 0 | 1,547 | +1,547 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 17,771 | 18,222 | +451 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 700,406 | 700,847 | +441 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,555 | 1,905 | +350 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 31,419 | 31,710 | +291 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,726 | 10,920 | +194 | 0.03 | 0.01 | -0.02 | buy |
| NISA INVESTMENT ADVISORS, LLC | 606 | 660 | +54 | 0.00 | 0.00 | -0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,790 | 2,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 71,730 | 71,730 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 41,000 | 41,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 66,211 | 66,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| venBio Partners LLC | 9,699,925 | 9,699,925 | 0 | 25.26 | 9.08 | -16.18 | hold |
| Nan Fung Group Holdings Ltd | 41,950 | 41,950 | 0 | 0.27 | 0.07 | -0.20 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,622 | 10,622 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,522 | 12,522 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 4,100 | 4,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 897 | 897 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Creekmur Asset Management LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 85 | 71 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 79 | 0 | -79 | 0.00 | 0.00 | 0.00 | sell |
| Private Wealth Management Group, LLC | 98 | 0 | -98 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 204 | 0 | -204 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,579 | 7,347 | -232 | 0.00 | 0.00 | -0.00 | sell |
| Smartleaf Asset Management LLC | 631 | 372 | -259 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 411 | 0 | -411 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 2,331 | 98 | -2,233 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2,329 | 0 | -2,329 | 0.00 | 0.00 | -0.00 | sell |
| CANADA LIFE ASSURANCE Co | 2,379 | 0 | -2,379 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,517 | 1,244 | -5,273 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 6,600 | 0 | -6,600 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 10,098 | 0 | -10,098 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 10,290 | 0 | -10,290 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 10,292 | 0 | -10,292 | 0.01 | 0.00 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 10,575 | 0 | -10,575 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,020 | 225,302 | -10,718 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 12,600 | 0 | -12,600 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 55,220 | 42,111 | -13,109 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,662 | 0 | -13,662 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 16,140 | 0 | -16,140 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 20,781 | 0 | -20,781 | 0.02 | 0.00 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 21,823 | 0 | -21,823 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 25,887 | 3,860 | -22,027 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,254 | 2,393 | -22,861 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 23,685 | 0 | -23,685 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,561 | 0 | -24,561 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 104,966 | 80,380 | -24,586 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 705,547 | 671,376 | -34,171 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 41,215 | 0 | -41,215 | 0.01 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 44,149 | 0 | -44,149 | 0.00 | 0.00 | -0.00 | sell |