| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 492,614 | 2,622,861 | +2,130,247 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 795,777 | +795,777 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 652,897 | +652,897 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 180,416 | +180,416 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 477,934 | 606,671 | +128,737 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 92,233 | +92,233 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 85,399 | 164,499 | +79,100 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 61,899 | +61,899 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 315,421 | 352,335 | +36,914 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 36,000 | +36,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 22,535 | +22,535 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 703,300 | 719,800 | +16,500 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 8,025 | +8,025 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 81,326 | 88,165 | +6,839 | 0.00 | 0.01 | +0.01 | buy |
| HC Advisors, LLC | 20,500 | 21,850 | +1,350 | 0.01 | 0.03 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 19,292 | 20,572 | +1,280 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| MONETA GROUP INVESTMENT ADVISORS LLC | 15,196 | 15,196 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 41,000 | 41,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Lido Advisors, LLC | 13,220 | 13,220 | 0 | 0.00 | 0.00 | +0.00 | hold |
| venBio Partners LLC | 9,699,925 | 9,699,925 | 0 | 3.51 | 10.06 | +6.55 | hold |
| NAN FUNG TRINITY (HK) Ltd | 41,950 | 41,950 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Privium Fund Management B.V. | 509,059 | 509,059 | 0 | 0.05 | 0.17 | +0.12 | hold |
| JSF Financial, LLC | 17,500 | 17,500 | 0 | 0.00 | 0.01 | +0.01 | hold |
| SBI Securities Co., Ltd. | 422 | 422 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Callan Family Office, LLC | 19,778 | 19,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 10,567 | 10,567 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF NOVA SCOTIA | 105,858 | 105,858 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 629 | 499 | -130 | 0.00 | 0.00 | +0.00 | sell |
| Clearstead Advisors, LLC | 177 | 0 | -177 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,471 | 1,106 | -365 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,678 | 480 | -1,198 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 39,279 | 38,073 | -1,206 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 1,304 | 0 | -1,304 | 0.00 | 0.00 | -0.00 | sell |
| Almitas Capital LLC | 2,538,355 | 2,536,891 | -1,464 | 0.27 | 1.06 | +0.80 | sell |
| HSBC HOLDINGS PLC | 12,306 | 10,817 | -1,489 | 0.00 | 0.00 | +0.00 | sell |
| Abel Hall, LLC | 15,209 | 12,598 | -2,611 | 0.00 | 0.01 | +0.01 | sell |
| FEDERATED HERMES, INC. | 6,541 | 2,374 | -4,167 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 18,033 | 12,986 | -5,047 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 5,194 | 0 | -5,194 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,277 | 3,838 | -6,439 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 9,010 | 2,278 | -6,732 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 124,232 | 111,928 | -12,304 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 27,709 | 13,907 | -13,802 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 44,133 | 16,946 | -27,187 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 45,583 | 10,793 | -34,790 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 135,909 | 95,160 | -40,749 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,267,999 | 1,220,825 | -47,174 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 74,770 | 26,621 | -48,149 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 58,307 | 0 | -58,307 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 3,391,455 | 3,332,983 | -58,472 | 0.15 | 0.59 | +0.44 | sell |
| MARSHALL WACE, LLP | 106,280 | 39,583 | -66,697 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 1,600,808 | 1,528,619 | -72,189 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 133,433 | 0 | -133,433 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 668,747 | 474,781 | -193,966 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 716,297 | 447,692 | -268,605 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 289,693 | 0 | -289,693 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,035,127 | 530,828 | -504,299 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 3,158,265 | 0 | -3,158,265 | 0.07 | 0.00 | -0.07 | sell |