| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 612,079 | 3,142,079 | +2,530,000 | 0.17 | 2.24 | +2.07 | buy |
| Redmile Group, LLC | 1,283,289 | 3,659,264 | +2,375,975 | 0.29 | 1.95 | +1.66 | buy |
| FMR LLC | 5,591,947 | 7,472,821 | +1,880,874 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 0 | 1,264,759 | +1,264,759 | 0.00 | 4.41 | +4.41 | buy |
| Point72 Asset Management, L.P. | 0 | 913,700 | +913,700 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 425,217 | 1,233,107 | +807,890 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 543,243 | +543,243 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,008,236 | 1,502,409 | +494,173 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 385,232 | +385,232 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,871,000 | 3,095,000 | +224,000 | 0.30 | 0.92 | +0.63 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 160,000 | +160,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 443,067 | 585,034 | +141,967 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 389,359 | 501,496 | +112,137 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 104,600 | +104,600 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 80,688 | +80,688 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 333,483 | 413,793 | +80,310 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 77,830 | +77,830 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 0 | 70,400 | +70,400 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 140,734 | 208,164 | +67,430 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 66,211 | +66,211 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 65,921 | +65,921 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 65,814 | +65,814 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 212,500 | 270,500 | +58,000 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 191,524 | 243,840 | +52,316 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 48,059 | +48,059 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 43,598 | +43,598 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 30,988 | +30,988 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 30,391 | +30,391 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 21,735 | 47,583 | +25,848 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 24,946 | +24,946 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Trading LLC | 0 | 23,032 | +23,032 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 10,069 | 30,348 | +20,279 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 26,964 | 44,637 | +17,673 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 14,561 | +14,561 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,389 | +14,389 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 72,050 | 86,306 | +14,256 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 13,309 | +13,309 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 51,748 | 64,756 | +13,008 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 11,569 | +11,569 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 10,257 | 21,196 | +10,939 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 10,708 | +10,708 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 8,434 | +8,434 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 8,296 | +8,296 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 5,600 | +5,600 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,056 | 5,762 | +4,706 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 45,682 | 50,178 | +4,496 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 523 | 4,743 | +4,220 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,441 | 7,561 | +4,120 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 10,798 | 13,398 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 1,907 | +1,907 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 1,579 | +1,579 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,419 | 2,790 | +1,371 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,605 | 2,289 | +684 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 10,789 | 11,122 | +333 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 10,425 | 10,702 | +277 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| BOURGEON CAPITAL MANAGEMENT LLC | 19,570 | 19,570 | 0 | 0.02 | 0.06 | +0.04 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,290 | 40,290 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 41,000 | 41,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 4,220,048 | 4,220,048 | 0 | 2.22 | 5.14 | +2.93 | hold |
| Parallel Advisors, LLC | 329 | 329 | 0 | 0.00 | 0.00 | +0.00 | hold |
| venBio Partners LLC | 9,699,925 | 9,699,925 | 0 | 13.20 | 21.65 | +8.45 | hold |
| Nan Fung Group Holdings Ltd | 41,950 | 41,950 | 0 | 0.16 | 0.39 | +0.23 | hold |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Red Tortoise LLC | 340 | 340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 392 | 392 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Newbridge Financial Services Group, Inc. | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,055 | 1,871 | -184 | 0.00 | 0.00 | +0.00 | sell |
| COMERICA BANK | 688 | 456 | -232 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,774 | 4,437 | -337 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,918 | 12,487 | -431 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 134,739 | 134,222 | -517 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 9,460 | 7,880 | -1,580 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 1,932 | 0 | -1,932 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 44,609 | 42,109 | -2,500 | 0.00 | 0.01 | +0.01 | sell |
| RHUMBLINE ADVISERS | 50,957 | 48,154 | -2,803 | 0.00 | 0.00 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 10,727 | 7,019 | -3,708 | 0.03 | 0.07 | +0.04 | sell |
| XTX Topco Ltd | 10,740 | 0 | -10,740 | 0.01 | 0.00 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10,900 | 0 | -10,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 11,600 | 0 | -11,600 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 11,649 | 0 | -11,649 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,084 | 39,515 | -12,569 | 0.00 | 0.00 | +0.00 | sell |
| Forefront Analytics, LLC | 13,769 | 0 | -13,769 | 0.04 | 0.00 | -0.04 | sell |
| ZACKS INVESTMENT MANAGEMENT | 13,918 | 0 | -13,918 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 14,269 | 0 | -14,269 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 48,500 | 33,500 | -15,000 | 0.01 | 0.01 | +0.01 | sell |
| HSBC HOLDINGS PLC | 35,404 | 17,793 | -17,611 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 146,677 | 123,420 | -23,257 | 0.00 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 30,358 | 0 | -30,358 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 35,071 | 0 | -35,071 | 0.03 | 0.00 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 131,127 | 90,743 | -40,384 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 251,360 | 196,536 | -54,824 | 0.00 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 94,400 | 0 | -94,400 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 1,000,000 | 0 | -1,000,000 | 0.68 | 0.00 | -0.68 | sell |
| BRAIDWELL LP | 1,249,900 | 0 | -1,249,900 | 0.19 | 0.00 | -0.19 | sell |