| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| venBio Partners LLC | 9,699,925 | 9,699,925 | 0 | 9.08 | 9.49 | +0.41 | hold |
| Redmile Group, LLC | 3,836,576 | 3,689,611 | -146,965 | 0.41 | 0.43 | +0.02 | sell |
| TANG CAPITAL MANAGEMENT LLC | 4,204,735 | 3,296,883 | -907,852 | 0.55 | 0.36 | -0.18 | sell |
| MORGAN STANLEY | 0 | 2,499,102 | +2,499,102 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,601,776 | 2,384,247 | -217,529 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,002,374 | 2,129,110 | +126,736 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,884,573 | 1,887,002 | +2,429 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 5,865,106 | 1,851,556 | -4,013,550 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 2,409,862 | 1,391,434 | -1,018,428 | 0.66 | 0.33 | -0.33 | sell |
| Almitas Capital LLC | 0 | 1,222,945 | +1,222,945 | 0.00 | 0.45 | +0.45 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 426,424 | 1,109,448 | +683,024 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 174,623 | 1,035,326 | +860,703 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 826,582 | +826,582 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 500,500 | 823,900 | +323,400 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 700,847 | 740,106 | +39,259 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 660,059 | 704,131 | +44,072 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 671,376 | 684,123 | +12,747 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 256,879 | 569,009 | +312,130 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 509,059 | 509,059 | 0 | 0.23 | 0.19 | -0.04 | hold |
| UBS Group AG | 0 | 408,056 | +408,056 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 319,742 | 343,066 | +23,324 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 257,779 | 301,419 | +43,640 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 317,322 | 263,856 | -53,466 | 0.04 | 0.04 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 290,396 | 255,878 | -34,518 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 40,934 | 236,046 | +195,112 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 225,302 | 216,707 | -8,595 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 151,620 | +151,620 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 457,717 | 138,470 | -319,247 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF NOVA SCOTIA | 0 | 105,306 | +105,306 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 16,283 | 101,113 | +84,830 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 80,380 | 90,003 | +9,623 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 75,000 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 71,730 | 71,730 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aberdeen Group plc | 66,211 | 66,211 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 59,502 | 65,122 | +5,620 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 60,795 | +60,795 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 28,657 | 43,056 | +14,399 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 42,111 | 42,516 | +405 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 28,506 | 41,985 | +13,479 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 41,950 | 41,950 | 0 | 0.07 | 0.06 | -0.01 | hold |
| DekaBank Deutsche Girozentrale | 41,000 | 41,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 31,710 | 39,131 | +7,421 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 383,512 | 32,021 | -351,491 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 25,552 | 31,436 | +5,884 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 37,646 | 26,233 | -11,413 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 27,394 | 24,256 | -3,138 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,077 | 18,913 | +836 | 0.00 | 0.00 | -0.00 | buy |
| JSF Financial, LLC | 0 | 17,500 | +17,500 | 0.00 | 0.01 | +0.01 | buy |
| Corebridge Financial, Inc. | 18,222 | 17,129 | -1,093 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,840 | 16,909 | +1,069 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 13,919 | 16,154 | +2,235 | 0.00 | 0.00 | -0.00 | buy |
| HC Advisors, LLC | 15,775 | 15,475 | -300 | 0.02 | 0.02 | -0.00 | sell |
| MONETA GROUP INVESTMENT ADVISORS LLC | 0 | 15,196 | +15,196 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 15,315 | 15,112 | -203 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 17,146 | 14,567 | -2,579 | 0.00 | 0.00 | -0.00 | sell |
| Lido Advisors, LLC | 0 | 13,220 | +13,220 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,198 | +13,198 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,522 | 12,522 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 11,417 | +11,417 | 0.00 | 0.00 | +0.00 | buy |
| Forum Financial Management, LP | 0 | 11,299 | +11,299 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,622 | 10,622 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Abel Hall, LLC | 0 | 10,406 | +10,406 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 7,347 | 5,001 | -2,346 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 0 | 4,483 | +4,483 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 4,100 | 4,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 3,860 | 3,860 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,790 | 2,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,393 | 2,393 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 71 | 2,204 | +2,133 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 1,270 | +1,270 | 0.00 | 0.00 | +0.00 | buy |
| Bradley & Co. Private Wealth Management, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 897 | 897 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 660 | 702 | +42 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 390 | +390 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,244 | 237 | -1,007 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 98 | 228 | +130 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 34 | 34 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 155,300 | 0 | -155,300 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 12,813 | 0 | -12,813 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 96,849 | 0 | -96,849 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 160,059 | 0 | -160,059 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 48,204 | 0 | -48,204 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 133,025 | 0 | -133,025 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 138 | 0 | -138 | 0.00 | 0.00 | 0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,905 | 0 | -1,905 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 10,920 | 0 | -10,920 | 0.01 | 0.00 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 83,042 | 0 | -83,042 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 1,547 | 0 | -1,547 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 137,983 | 0 | -137,983 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 9,369 | 0 | -9,369 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 4,034,522 | 0 | -4,034,522 | 0.61 | 0.00 | -0.61 | sell |
| ExodusPoint Capital Management, LP | 11,527 | 0 | -11,527 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 230,875 | 0 | -230,875 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 24,003 | 0 | -24,003 | 0.01 | 0.00 | -0.01 | sell |
| Allspring Global Investments Holdings, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 20 | 0 | -20 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,130 | 0 | -10,130 | 0.00 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 34,373 | 0 | -34,373 | 0.01 | 0.00 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 26,161 | 0 | -26,161 | 0.00 | 0.00 | -0.00 | sell |
| Smartleaf Asset Management LLC | 372 | 0 | -372 | 0.00 | 0.00 | -0.00 | sell |