| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 26,130,659 | 27,737,077 | +1,606,418 | 0.00 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 1,336,231 | +1,336,231 | 0.00 | 1.69 | +1.69 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 207,838 | 1,354,632 | +1,146,794 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 486,752 | 1,605,706 | +1,118,954 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 0 | 772,652 | +772,652 | 0.00 | 0.32 | +0.32 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 211,479 | 748,793 | +537,314 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 645,804 | 1,174,464 | +528,660 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 802,544 | 1,181,601 | +379,057 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,000,000 | 1,374,870 | +374,870 | 0.24 | 0.61 | +0.37 | buy |
| D. E. Shaw & Co., Inc. | 514,930 | 860,940 | +346,010 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 794,108 | 1,139,826 | +345,718 | 0.00 | 0.00 | +0.00 | buy |
| Greenland Capital Management LP | 0 | 344,660 | +344,660 | 0.00 | 0.02 | +0.02 | buy |
| Informed Momentum Co LLC | 0 | 224,051 | +224,051 | 0.00 | 0.13 | +0.13 | buy |
| VANGUARD GROUP INC | 7,314,615 | 7,534,148 | +219,533 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 212,113 | +212,113 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 74,228 | 234,030 | +159,802 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 42,238 | 197,660 | +155,422 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 154,200 | +154,200 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 127,683 | +127,683 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 110,419 | +110,419 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,419 | 114,946 | +99,527 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 90,797 | +90,797 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 233,122 | 322,014 | +88,892 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 293,703 | 382,180 | +88,477 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,046,325 | 3,127,198 | +80,873 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 460,471 | 537,317 | +76,846 | 0.35 | 0.99 | +0.64 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 68,677 | 125,346 | +56,669 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 181,122 | 234,440 | +53,318 | 0.08 | 0.22 | +0.15 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,500,000 | 3,551,864 | +51,864 | 0.49 | 1.35 | +0.86 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 49,200 | +49,200 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 67,100 | 111,968 | +44,868 | 0.00 | 0.02 | +0.01 | buy |
| UBS Group AG | 381,319 | 423,802 | +42,483 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 38,254 | +38,254 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 0 | 30,651 | +30,651 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 28,761 | +28,761 | 0.00 | 0.02 | +0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 107,843 | 130,107 | +22,264 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 238,330 | 260,279 | +21,949 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 21,732 | +21,732 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,126,663 | 1,148,027 | +21,364 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 0 | 20,895 | +20,895 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 20,526 | +20,526 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 20,069 | +20,069 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 18,350 | +18,350 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 174,944 | 191,541 | +16,597 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 12,109 | +12,109 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 13,997 | 25,285 | +11,288 | 0.00 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,220,237 | 1,231,337 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 8,215 | +8,215 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 8,575 | 16,714 | +8,139 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 44,871 | 51,483 | +6,612 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 79,288 | 85,391 | +6,103 | 0.00 | 0.00 | +0.00 | buy |
| Princeton Global Asset Management LLC | 0 | 5,000 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 81,666 | 85,859 | +4,193 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 2,241 | +2,241 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 24,111 | 26,173 | +2,062 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 10,000 | 11,569 | +1,569 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,938 | 5,276 | +1,338 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 359,671 | 360,844 | +1,173 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 468 | +468 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 16,052 | 16,199 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 266 | 384 | +118 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 127,050 | 127,150 | +100 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 7,066 | 7,114 | +48 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 127 | 144 | +17 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 8 | +8 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 14,367 | 14,367 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 118,057 | 118,057 | 0 | 0.03 | 0.07 | +0.04 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.18 | 0.43 | +0.25 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.16 | 0.40 | +0.24 | hold |
| SIGNATUREFD, LLC | 1,126 | 1,126 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AWM Investment Company, Inc. | 1,350,000 | 1,350,000 | 0 | 0.27 | 0.64 | +0.38 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.00 | 0.02 | +0.01 | hold |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.04 | 0.09 | +0.05 | hold |
| EcoR1 Capital, LLC | 19,209,643 | 19,209,643 | 0 | 0.75 | 1.78 | +1.02 | hold |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tortoise Investment Management, LLC | 13,752 | 13,752 | 0 | 0.00 | 0.01 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 1,095 | 1,095 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Beacon Pointe Advisors, LLC | 21,700 | 21,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 133,333 | 133,333 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Aisling Capital Management LP | 2,541,009 | 2,541,009 | 0 | 1.14 | 3.13 | +1.99 | hold |
| Avidity Partners Management LP | 89,543 | 89,543 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Logos Global Management LP | 66,666 | 66,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hunter Perkins Capital Management, LLC | 23,000 | 23,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Fortitude Family Office, LLC | 381 | 381 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 1,638 | 1,638 | 0 | 0.00 | 0.00 | +0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 116,748 | 116,748 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 36,321 | 36,321 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 48,172 | 47,979 | -193 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 19,374 | 18,846 | -528 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 72,411 | 71,794 | -617 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 17,545 | 16,347 | -1,198 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 61,091 | 59,151 | -1,940 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 36,900 | 34,700 | -2,200 | 0.00 | 0.00 | +0.00 | sell |