| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 312,336 | 27,330,800 | +27,018,464 | 0.14 | 6.57 | +6.43 | buy |
| FMR LLC | 45,285,572 | 50,599,225 | +5,313,653 | 0.01 | 0.01 | -0.00 | buy |
| Laurion Capital Management LP | 6,491,475 | 9,871,077 | +3,379,602 | 1.07 | 1.34 | +0.26 | buy |
| Rosalind Advisors, Inc. | 0 | 2,451,500 | +2,451,500 | 0.00 | 2.10 | +2.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,475,872 | 3,774,003 | +1,298,131 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,227,152 | 2,492,882 | +1,265,730 | 0.00 | 0.00 | +0.00 | buy |
| Knoll Capital Management, LLC | 0 | 1,025,000 | +1,025,000 | 0.00 | 1.17 | +1.17 | buy |
| MORGAN STANLEY | 1,072,836 | 1,969,970 | +897,134 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 0 | 650,000 | +650,000 | 0.00 | 0.16 | +0.16 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 592,119 | +592,119 | 0.00 | 0.02 | +0.02 | buy |
| Ikarian Capital, LLC | 83,407 | 619,258 | +535,851 | 0.06 | 0.36 | +0.29 | buy |
| MPM BioImpact LLC | 4,164,178 | 4,652,243 | +488,065 | 1.57 | 1.41 | -0.16 | buy |
| GSA CAPITAL PARTNERS LLP | 242,253 | 661,052 | +418,799 | 0.05 | 0.11 | +0.06 | buy |
| GROUP ONE TRADING LLC | 0 | 268,520 | +268,520 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 4,599,993 | 4,856,016 | +256,023 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 249,081 | +249,081 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,951,195 | 5,130,604 | +179,409 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 21,010 | 187,603 | +166,593 | 0.00 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 312,336 | 468,000 | +155,664 | 0.14 | 0.70 | +0.56 | buy |
| ALGERT GLOBAL LLC | 871,469 | 1,005,226 | +133,757 | 0.05 | 0.04 | -0.01 | buy |
| Graham Capital Management, L.P. | 0 | 119,249 | +119,249 | 0.00 | 0.01 | +0.01 | buy |
| Exome Asset Management LLC | 0 | 96,311 | +96,311 | 0.00 | 0.15 | +0.15 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 347,806 | 435,917 | +88,111 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 411,173 | 486,535 | +75,362 | 0.00 | 0.00 | -0.00 | buy |
| Beacon Pointe Advisors, LLC | 53,550 | 127,050 | +73,500 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,279,712 | 1,349,763 | +70,051 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 62,421 | +62,421 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 56,660 | +56,660 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 143,223 | 189,659 | +46,436 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 10,585 | 55,564 | +44,979 | 0.00 | 0.01 | +0.00 | buy |
| Palumbo Wealth Management LLC | 65,360 | 109,643 | +44,283 | 0.06 | 0.06 | -0.00 | buy |
| Intellectus Partners, LLC | 280,905 | 320,905 | +40,000 | 0.17 | 0.14 | -0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 76,506 | 115,962 | +39,456 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 330,388 | 367,772 | +37,384 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 20,166 | 45,448 | +25,282 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 23,662 | +23,662 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 16,967 | 40,230 | +23,263 | 0.00 | 0.00 | +0.00 | buy |
| FIRETHORN WEALTH PARTNERS, LLC | 0 | 20,052 | +20,052 | 0.00 | 0.02 | +0.02 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 16,842 | +16,842 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 676,024 | 692,673 | +16,649 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 17,070 | 32,455 | +15,385 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 33,671 | 47,185 | +13,514 | 0.00 | 0.00 | -0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 19,011 | 30,179 | +11,168 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 638 | 10,703 | +10,065 | 0.00 | 0.00 | +0.00 | buy |
| Swisher Financial Concepts, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 31,279 | 40,474 | +9,195 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 24,327 | 31,652 | +7,325 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 225,025 | 231,821 | +6,796 | 0.00 | 0.00 | -0.00 | buy |
| Pale Fire Capital SE | 39,000 | 45,642 | +6,642 | 0.02 | 0.01 | -0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 54,548 | 60,951 | +6,403 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 0 | 5,092 | +5,092 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 103,939 | 108,547 | +4,608 | 0.00 | 0.00 | -0.00 | buy |
| Pallas Capital Advisors LLC | 17,016 | 20,279 | +3,263 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,306 | 7,214 | +2,908 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 106,416 | 108,822 | +2,406 | 0.00 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 136,435 | 138,816 | +2,381 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 1,941 | +1,941 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 10,139 | 11,758 | +1,619 | 0.00 | 0.00 | -0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 1,016 | 2,602 | +1,586 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 12,215 | 13,615 | +1,400 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 4,978 | 6,257 | +1,279 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 801 | +801 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 468 | 1,233 | +765 | 0.00 | 0.00 | -0.00 | buy |
| XPONANCE, INC. | 12,443 | 13,127 | +684 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 95 | 665 | +570 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 7,000 | 7,505 | +505 | 0.00 | 0.00 | -0.00 | buy |
| Rise Advisors, LLC | 0 | 497 | +497 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 518,575 | 518,867 | +292 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 237 | +237 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 270 | 500 | +230 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 122 | +122 | 0.00 | 0.00 | 0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 36 | 37 | +1 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 17,567 | 17,567 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 200,380 | 200,380 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 197,389 | 197,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 101,561 | 101,561 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,900,000 | 3,900,000 | 0 | 0.69 | 0.38 | -0.31 | hold |
| JANUS HENDERSON GROUP PLC | 76,700 | 76,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.32 | 0.26 | -0.06 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.16 | 0.12 | -0.04 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,050 | 43,050 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 166,579 | 166,579 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.56 | 0.50 | -0.06 | hold |
| SIGNATUREFD, LLC | 1,126 | 1,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Neuberger Berman Group LLC | 11,711 | 11,711 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DME Capital Management, LP | 34,995 | 34,995 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 426,700 | 426,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.02 | 0.02 | -0.00 | hold |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.10 | 0.10 | -0.00 | hold |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tortoise Investment Management, LLC | 13,752 | 13,752 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 13,072,340 | 13,072,340 | 0 | 22.55 | 13.58 | -8.98 | hold |
| IFP Advisors, Inc | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Intellectus Partners, LLC | 22,396 | 22,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 15,895 | 15,895 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CLEAR STREET LLC | 1,200 | 1,200 | 0 | 0.00 | 0.00 | -0.00 | hold |