| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 51,424,981 | 51,989,593 | +564,612 | 0.02 | 0.01 | -0.01 | buy |
| Decheng Capital LLC | 25,954,439 | 25,954,439 | 0 | 31.28 | 16.84 | -14.45 | hold |
| BlackRock, Inc. | 24,669,776 | 25,100,374 | +430,598 | 0.00 | 0.00 | -0.00 | buy |
| Omega Fund Management, LLC | 8,081,089 | 8,081,089 | 0 | 25.27 | 21.25 | -4.02 | hold |
| Laurion Capital Management LP | 7,852,638 | 7,822,638 | -30,000 | 4.80 | 3.15 | -1.65 | sell |
| STATE STREET CORP | 5,858,782 | 6,784,927 | +926,145 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,712,296 | 5,863,654 | +151,358 | 0.00 | 0.00 | -0.00 | buy |
| Duquesne Family Office LLC | 0 | 4,539,800 | +4,539,800 | 0.00 | 0.66 | +0.66 | buy |
| BANK OF AMERICA CORP /DE/ | 3,809,425 | 3,219,826 | -589,599 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 3,163,256 | 3,153,256 | -10,000 | 2.09 | 0.90 | -1.19 | sell |
| TANG CAPITAL MANAGEMENT LLC | 3,857,457 | 3,149,557 | -707,900 | 1.71 | 0.69 | -1.02 | sell |
| AMERICAN CENTURY COMPANIES INC | 36,816 | 2,897,078 | +2,860,262 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 735,945 | 2,684,089 | +1,948,144 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 134,999 | 2,065,411 | +1,930,412 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,066,360 | 2,052,691 | -13,669 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,280,899 | 2,042,312 | +761,413 | 0.02 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,921,732 | 2,003,108 | +81,376 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,669,166 | 1,995,758 | +326,592 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,016,681 | 1,992,451 | -24,230 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,696,013 | 1,929,953 | +233,940 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,276,128 | 1,871,217 | +595,089 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 291,108 | 1,842,078 | +1,550,970 | 0.04 | 0.12 | +0.08 | buy |
| ARMISTICE CAPITAL, LLC | 1,263,737 | 1,736,000 | +472,263 | 0.28 | 0.25 | -0.03 | buy |
| Knoll Capital Management, LLC | 1,498,591 | 1,498,591 | 0 | 6.16 | 3.57 | -2.59 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 819,632 | 1,439,357 | +619,725 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 615,402 | 1,373,947 | +758,545 | 0.00 | 0.00 | -0.00 | buy |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 1,270,504 | -2,541,009 | 0.60 | 0.12 | -0.48 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 191,998 | 1,207,771 | +1,015,773 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 711,544 | 1,122,180 | +410,636 | 0.00 | 0.00 | -0.00 | buy |
| NewEdge Advisors, LLC | 952,166 | 1,031,112 | +78,946 | 0.03 | 0.02 | -0.01 | buy |
| Woodline Partners LP | 957,914 | 960,414 | +2,500 | 0.03 | 0.02 | -0.02 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 724,383 | +724,383 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 687,228 | 683,497 | -3,731 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 899,988 | 672,144 | -227,844 | 0.00 | 0.00 | -0.00 | sell |
| Beacon Pointe Advisors, LLC | 259,212 | 643,734 | +384,522 | 0.02 | 0.01 | -0.00 | buy |
| Man Group plc | 0 | 632,238 | +632,238 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 559,180 | +559,180 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 595,045 | 539,162 | -55,883 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 2,852,001 | 514,117 | -2,337,884 | 0.01 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 521,038 | 512,161 | -8,877 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 538,079 | 508,846 | -29,233 | 0.67 | 0.33 | -0.34 | sell |
| GSA CAPITAL PARTNERS LLP | 14,111 | 495,792 | +481,681 | 0.01 | 0.13 | +0.12 | buy |
| Hennion & Walsh Asset Management, Inc. | 445,279 | 450,594 | +5,315 | 0.14 | 0.07 | -0.07 | buy |
| Invesco Ltd. | 1,185,143 | 437,806 | -747,337 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 437,400 | 437,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 875,802 | 392,986 | -482,816 | 0.01 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 0 | 392,754 | +392,754 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 243,848 | 392,754 | +148,906 | 0.17 | 0.11 | -0.06 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 256,986 | 378,157 | +121,171 | 0.01 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 254,103 | 344,163 | +90,060 | 0.00 | 0.00 | -0.00 | buy |
| Propel Bio Management, LLC | 0 | 329,296 | +329,296 | 0.00 | 0.89 | +0.89 | buy |
| CITIGROUP INC | 63,082 | 315,776 | +252,694 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 308,189 | 303,881 | -4,308 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 213,670 | 303,784 | +90,114 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,708,553 | 303,624 | -2,404,929 | 0.00 | 0.00 | -0.00 | sell |
| Intellectus Partners, LLC | 285,417 | 290,417 | +5,000 | 0.49 | 0.25 | -0.24 | buy |
| ALPS ADVISORS INC | 280,900 | 282,151 | +1,251 | 0.01 | 0.01 | -0.01 | buy |
| Russell Investments Group, Ltd. | 24,456 | 265,700 | +241,244 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 169,600 | 262,557 | +92,957 | 0.02 | 0.02 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 229,089 | 237,503 | +8,414 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 274,061 | 233,352 | -40,709 | 0.01 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 34,784 | 230,106 | +195,322 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 190,817 | 212,755 | +21,938 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 702,017 | 205,454 | -496,563 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 271,937 | 189,910 | -82,027 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 177,260 | +177,260 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 175,056 | +175,056 | 0.00 | 0.11 | +0.11 | buy |
| Legal & General Group Plc | 192,867 | 174,172 | -18,695 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 60,308 | 163,687 | +103,379 | 0.01 | 0.01 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 147,875 | +147,875 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 143,613 | +143,613 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 142,362 | +142,362 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 41,099 | 139,257 | +98,158 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Management, LLC | 113,565 | 133,065 | +19,500 | 0.04 | 0.02 | -0.02 | buy |
| MetLife Investment Management, LLC | 138,178 | 127,912 | -10,266 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 124,944 | +124,944 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 118,640 | 121,040 | +2,400 | 0.00 | 0.00 | -0.00 | buy |
| WEXFORD CAPITAL LP | 130,000 | 120,889 | -9,111 | 0.30 | 0.09 | -0.21 | sell |
| Aquatic Capital Management LLC | 0 | 119,253 | +119,253 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 184 | 118,593 | +118,409 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 439,272 | 114,491 | -324,781 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 112,040 | 113,020 | +980 | 0.00 | 0.00 | -0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 14,152 | 112,170 | +98,018 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 108,400 | 108,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wealthcare Advisory Partners LLC | 106,952 | 106,999 | +47 | 0.02 | 0.01 | -0.01 | buy |
| CWM, LLC | 102,378 | 106,444 | +4,066 | 0.00 | 0.00 | -0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 105,000 | +105,000 | 0.00 | 0.10 | +0.10 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 278,831 | 104,682 | -174,149 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 1,234,273 | 103,546 | -1,130,727 | 0.01 | 0.00 | -0.01 | sell |
| Creative Planning | 107,714 | 101,424 | -6,290 | 0.00 | 0.00 | -0.00 | sell |
| Palumbo Wealth Management LLC | 163,756 | 100,963 | -62,793 | 0.36 | 0.11 | -0.26 | sell |
| Virtus Investment Advisers, LLC | 81,068 | 100,151 | +19,083 | 0.20 | 0.12 | -0.08 | buy |
| Cerity Partners LLC | 96,652 | 93,963 | -2,689 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 61,791 | 87,387 | +25,596 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 11,649 | 84,710 | +73,061 | 0.02 | 0.05 | +0.02 | buy |
| State of New Jersey Common Pension Fund D | 75,714 | 75,811 | +97 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 62,395 | 74,480 | +12,085 | 0.00 | 0.00 | +0.00 | buy |
| BRIGHTON JONES LLC | 0 | 74,032 | +74,032 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 71,081 | +71,081 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 68,728 | 68,728 | 0 | 0.00 | 0.00 | -0.00 | hold |