| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 27,737,077 | 28,821,939 | +1,084,862 | 0.01 | 0.01 | -0.00 | buy |
| EcoR1 Capital, LLC | 19,209,643 | 19,209,643 | 0 | 1.78 | 1.72 | -0.06 | hold |
| Omega Fund Management, LLC | 14,072,340 | 13,275,884 | -796,456 | 33.05 | 28.72 | -4.32 | sell |
| VANGUARD GROUP INC | 7,534,148 | 10,142,898 | +2,608,750 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 0 | 6,950,239 | +6,950,239 | 0.00 | 6.22 | +6.22 | buy |
| STATE STREET CORP | 3,043,510 | 3,975,410 | +931,900 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,127,198 | 3,832,445 | +705,247 | 0.00 | 0.00 | -0.00 | buy |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.43 | 0.22 | -0.22 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,551,864 | 3,751,864 | +200,000 | 1.35 | 1.12 | -0.23 | buy |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.40 | 0.54 | +0.13 | hold |
| Aisling Capital Management LP | 2,541,009 | 2,541,009 | 0 | 3.13 | 3.21 | +0.08 | hold |
| CITADEL ADVISORS LLC | 2,099,595 | 1,996,217 | -103,378 | 0.01 | 0.01 | -0.00 | sell |
| Laurion Capital Management LP | 0 | 1,591,475 | +1,591,475 | 0.00 | 0.15 | +0.15 | buy |
| BARCLAYS PLC | 1,605,706 | 1,552,138 | -53,568 | 0.00 | 0.00 | -0.00 | sell |
| AWM Investment Company, Inc. | 1,350,000 | 1,350,000 | 0 | 0.64 | 0.53 | -0.11 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,148,027 | 1,333,425 | +185,398 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 748,793 | 1,281,376 | +532,583 | 0.01 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,231,337 | 1,267,315 | +35,978 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,139,826 | 1,139,506 | -320 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,154,057 | 1,069,801 | -84,256 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,181,601 | 1,038,686 | -142,915 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 197,660 | 1,018,329 | +820,669 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.09 | 0.09 | -0.00 | hold |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.32 | 0.26 | -0.06 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 974,700 | 761,000 | -213,700 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,018,600 | 745,800 | -272,800 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 705,405 | 727,728 | +22,323 | 0.00 | 0.00 | -0.00 | buy |
| Sio Capital Management, LLC | 1,336,231 | 668,115 | -668,116 | 1.69 | 0.74 | -0.96 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,174,464 | 653,184 | -521,280 | 0.01 | 0.01 | -0.01 | sell |
| Decheng Capital LLC | 0 | 646,057 | +646,057 | 0.00 | 0.03 | +0.03 | buy |
| PANAGORA ASSET MANAGEMENT INC | 212,113 | 633,676 | +421,563 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 469,394 | 626,905 | +157,511 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 610,723 | 608,683 | -2,040 | 0.02 | 0.01 | -0.01 | sell |
| Assenagon Asset Management S.A. | 574,410 | 574,410 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 566,837 | +566,837 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 555,069 | +555,069 | 0.00 | 0.15 | +0.15 | buy |
| Clearline Capital LP | 437,237 | 437,237 | 0 | 0.16 | 0.11 | -0.05 | hold |
| Octagon Capital Advisors LP | 1,374,870 | 431,600 | -943,270 | 0.61 | 0.21 | -0.40 | sell |
| ALGERT GLOBAL LLC | 111,968 | 426,603 | +314,635 | 0.02 | 0.04 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 904,290 | 422,312 | -481,978 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 423,802 | 399,583 | -24,219 | 0.00 | 0.00 | -0.00 | sell |
| Acuitas Investments, LLC | 537,317 | 365,741 | -171,576 | 0.99 | 0.57 | -0.42 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 382,180 | 363,925 | -18,255 | 0.01 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 360,844 | 361,406 | +562 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 633,282 | 358,282 | -275,000 | 0.63 | 0.33 | -0.30 | sell |
| Greenland Capital Management LP | 344,660 | 344,660 | 0 | 0.02 | 0.01 | -0.01 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 340,331 | +340,331 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 322,014 | 325,208 | +3,194 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 365,326 | 323,661 | -41,665 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 113,653 | 297,329 | +183,676 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 0 | 265,800 | +265,800 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 262,205 | +262,205 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 207,550 | 260,939 | +53,389 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 234,440 | 246,905 | +12,465 | 0.22 | 0.20 | -0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 110,419 | 243,358 | +132,939 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 234,289 | +234,289 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 234,030 | 234,030 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,354,632 | 220,319 | -1,134,313 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 127,683 | 216,814 | +89,131 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 192,204 | 197,389 | +5,185 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 197,017 | +197,017 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 224,051 | 182,876 | -41,175 | 0.13 | 0.09 | -0.04 | sell |
| D. E. Shaw & Co., Inc. | 860,940 | 171,795 | -689,145 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 0 | 166,579 | +166,579 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 156,675 | 156,675 | 0 | 0.03 | 0.03 | -0.01 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,646 | 135,389 | +120,743 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 133,333 | 133,333 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 191,541 | 133,308 | -58,233 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 11,405 | 129,586 | +118,181 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 127,150 | 127,150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 116,748 | 111,964 | -4,784 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 18,350 | 111,583 | +93,233 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 260,279 | 110,626 | -149,653 | 0.00 | 0.00 | -0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 114,946 | 108,388 | -6,558 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 85,391 | 105,678 | +20,287 | 0.00 | 0.00 | -0.00 | buy |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 130,107 | 99,232 | -30,875 | 0.01 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 0 | 98,947 | +98,947 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 96,360 | +96,360 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Russell Investments Group, Ltd. | 33,579 | 90,064 | +56,485 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 158,814 | 89,849 | -68,965 | 0.02 | 0.01 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 51,483 | 78,989 | +27,506 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 76,700 | +76,700 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 21,732 | 76,494 | +54,762 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 85,859 | 72,329 | -13,530 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125,346 | 70,963 | -54,383 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 66,666 | 66,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marquette Asset Management, LLC | 97,741 | 66,037 | -31,704 | 0.06 | 0.03 | -0.03 | sell |
| WEXFORD CAPITAL LP | 25,285 | 63,267 | +37,982 | 0.02 | 0.05 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 52,005 | 60,833 | +8,828 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 59,151 | 59,101 | -50 | 0.00 | 0.00 | -0.00 | sell |
| Meridian Wealth Management, LLC | 0 | 56,345 | +56,345 | 0.00 | 0.02 | +0.02 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 118,057 | 55,509 | -62,548 | 0.07 | 0.03 | -0.04 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 47,979 | 48,128 | +149 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 46,300 | +46,300 | 0.00 | 0.02 | +0.02 | buy |