| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Decheng Capital LLC | 0 | 6,950,239 | +6,950,239 | 0.00 | 6.22 | +6.22 | buy |
| VANGUARD GROUP INC | 7,534,148 | 10,142,898 | +2,608,750 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 1,591,475 | +1,591,475 | 0.00 | 0.15 | +0.15 | buy |
| FMR LLC | 27,737,077 | 28,821,939 | +1,084,862 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 3,043,510 | 3,975,410 | +931,900 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 197,660 | 1,018,329 | +820,669 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,127,198 | 3,832,445 | +705,247 | 0.00 | 0.00 | -0.00 | buy |
| Decheng Capital LLC | 0 | 646,057 | +646,057 | 0.00 | 0.03 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 566,837 | +566,837 | 0.00 | 0.01 | +0.01 | buy |
| BIT Capital GmbH | 0 | 555,069 | +555,069 | 0.00 | 0.15 | +0.15 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 748,793 | 1,281,376 | +532,583 | 0.01 | 0.02 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 212,113 | 633,676 | +421,563 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 340,331 | +340,331 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 111,968 | 426,603 | +314,635 | 0.02 | 0.04 | +0.03 | buy |
| Swiss National Bank | 0 | 265,800 | +265,800 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 262,205 | +262,205 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 234,289 | +234,289 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,551,864 | 3,751,864 | +200,000 | 1.35 | 1.12 | -0.23 | buy |
| Qube Research & Technologies Ltd | 0 | 197,017 | +197,017 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,148,027 | 1,333,425 | +185,398 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 113,653 | 297,329 | +183,676 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 166,579 | +166,579 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 469,394 | 626,905 | +157,511 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 110,419 | 243,358 | +132,939 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,646 | 135,389 | +120,743 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 11,405 | 129,586 | +118,181 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 98,947 | +98,947 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 96,360 | +96,360 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 18,350 | 111,583 | +93,233 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 127,683 | 216,814 | +89,131 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 76,700 | +76,700 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 33,579 | 90,064 | +56,485 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Management, LLC | 0 | 56,345 | +56,345 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 21,732 | 76,494 | +54,762 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 207,550 | 260,939 | +53,389 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 46,300 | +46,300 | 0.00 | 0.02 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 43,050 | +43,050 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 41,690 | +41,690 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 25,285 | 63,267 | +37,982 | 0.02 | 0.05 | +0.03 | buy |
| Arizona State Retirement System | 0 | 37,829 | +37,829 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 37,566 | +37,566 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 1,231,337 | 1,267,315 | +35,978 | 0.00 | 0.00 | -0.00 | buy |
| WINTON GROUP Ltd | 0 | 30,350 | +30,350 | 0.00 | 0.01 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 0 | 30,276 | +30,276 | 0.00 | 0.04 | +0.04 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 29,731 | +29,731 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 29,672 | +29,672 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 51,483 | 78,989 | +27,506 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 26,784 | +26,784 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 705,405 | 727,728 | +22,323 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 22,317 | +22,317 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 22,177 | +22,177 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,720 | +21,720 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 85,391 | 105,678 | +20,287 | 0.00 | 0.00 | -0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 19,125 | +19,125 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 17,124 | +17,124 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 16,171 | +16,171 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 0 | 14,811 | +14,811 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 234,440 | 246,905 | +12,465 | 0.22 | 0.20 | -0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 12,215 | +12,215 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 11,351 | +11,351 | 0.00 | 0.00 | +0.00 | buy |
| B. Riley Wealth Advisors, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 1,095 | 11,095 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 16,347 | 25,950 | +9,603 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 52,005 | 60,833 | +8,828 | 0.00 | 0.00 | -0.00 | buy |
| Palumbo Wealth Management LLC | 20,069 | 28,350 | +8,281 | 0.03 | 0.03 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 7,056 | +7,056 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 192,204 | 197,389 | +5,185 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 34,700 | 38,600 | +3,900 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 322,014 | 325,208 | +3,194 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 16,714 | 19,873 | +3,159 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 12,109 | 14,883 | +2,774 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 18,846 | 21,195 | +2,349 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 2,212 | +2,212 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 11,569 | 13,357 | +1,788 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 8 | 1,094 | +1,086 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 4,040 | 4,978 | +938 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 360,844 | 361,406 | +562 | 0.00 | 0.00 | -0.00 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 144 | 409 | +265 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 234 | +234 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 47,979 | 48,128 | +149 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 14,367 | 14,367 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 156,675 | 156,675 | 0 | 0.03 | 0.03 | -0.01 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.32 | 0.26 | -0.06 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.43 | 0.22 | -0.22 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.40 | 0.54 | +0.13 | hold |
| SIGNATUREFD, LLC | 1,126 | 1,126 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DME Capital Management, LP | 34,995 | 34,995 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AWM Investment Company, Inc. | 1,350,000 | 1,350,000 | 0 | 0.64 | 0.53 | -0.11 | hold |
| Assenagon Asset Management S.A. | 574,410 | 574,410 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.02 | 0.01 | -0.01 | hold |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.09 | 0.09 | -0.00 | hold |
| EcoR1 Capital, LLC | 19,209,643 | 19,209,643 | 0 | 1.78 | 1.72 | -0.06 | hold |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tortoise Investment Management, LLC | 13,752 | 13,752 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Clearline Capital LP | 437,237 | 437,237 | 0 | 0.16 | 0.11 | -0.05 | hold |
| QUADRANT CAPITAL GROUP LLC | 468 | 468 | 0 | 0.00 | 0.00 | -0.00 | hold |