| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 50,599,225 | 51,039,313 | +440,088 | 0.01 | 0.01 | -0.00 | buy |
| Decheng Capital LLC | 25,954,439 | 25,954,439 | 0 | 12.81 | 12.78 | -0.03 | hold |
| BlackRock, Inc. | 18,478,787 | 25,732,990 | +7,254,203 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 15,397,820 | 15,903,054 | +505,234 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 13,072,340 | 11,042,728 | -2,029,612 | 13.58 | 13.94 | +0.37 | sell |
| Laurion Capital Management LP | 9,871,077 | 10,240,706 | +369,629 | 1.34 | 2.30 | +0.97 | buy |
| Octagon Capital Advisors LP | 481,000 | 7,691,334 | +7,210,334 | 0.53 | 3.29 | +2.76 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,130,604 | 5,994,798 | +864,194 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,856,016 | 5,558,984 | +702,968 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,105,846 | 5,532,976 | +3,427,130 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,774,003 | 5,380,185 | +1,606,182 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 4,652,243 | 4,622,590 | -29,653 | 1.41 | 1.56 | +0.15 | sell |
| TANG CAPITAL MANAGEMENT LLC | 3,900,000 | 3,900,000 | 0 | 0.38 | 0.38 | +0.00 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.12 | 0.12 | +0.00 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.50 | 0.63 | +0.12 | hold |
| DIMENSIONAL FUND ADVISORS LP | 2,492,882 | 2,769,741 | +276,859 | 0.00 | 0.00 | +0.00 | buy |
| Aisling Capital Management LP | 2,541,009 | 2,541,009 | 0 | 1.55 | 1.38 | -0.17 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,904,141 | 2,130,899 | +226,758 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 2,016,665 | 2,084,167 | +67,502 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 661,052 | 1,627,122 | +966,070 | 0.11 | 0.22 | +0.12 | buy |
| Nuveen, LLC | 453,792 | 1,485,334 | +1,031,542 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,024,623 | 1,478,044 | +453,421 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 746,094 | 1,322,859 | +576,765 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 687,378 | 1,214,733 | +527,355 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,969,970 | 1,209,803 | -760,167 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 135,409 | 1,137,292 | +1,001,883 | 0.00 | 0.00 | +0.00 | buy |
| Knoll Capital Management, LLC | 1,025,000 | 1,025,000 | 0 | 1.17 | 2.08 | +0.90 | hold |
| BARCLAYS PLC | 1,349,763 | 1,019,565 | -330,198 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.10 | 0.11 | +0.01 | hold |
| NATIXIS | 0 | 905,500 | +905,500 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 871,190 | +871,190 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 1,005,226 | 781,165 | -224,061 | 0.04 | 0.03 | -0.01 | sell |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.26 | 0.32 | +0.06 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 692,673 | 733,542 | +40,869 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 435,917 | 689,855 | +253,938 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 518,867 | 668,814 | +149,947 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 646,057 | 646,057 | 0 | 0.01 | 0.03 | +0.02 | hold |
| Ikarian Capital, LLC | 619,258 | 619,258 | 0 | 0.36 | 0.40 | +0.04 | hold |
| AMERICAN CENTURY COMPANIES INC | 486,535 | 547,929 | +61,394 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 871,692 | 473,939 | -397,753 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 358,800 | 454,900 | +96,100 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 426,700 | 426,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 249,081 | 395,539 | +146,458 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 367,772 | 393,414 | +25,642 | 0.00 | 0.00 | +0.00 | buy |
| Greenland Capital Management LP | 344,660 | 344,660 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Intellectus Partners, LLC | 320,905 | 329,805 | +8,900 | 0.14 | 0.14 | -0.00 | buy |
| X-Square Capital, LLC | 0 | 310,000 | +310,000 | 0.00 | 0.22 | +0.22 | buy |
| RHUMBLINE ADVISERS | 249,925 | 297,486 | +47,561 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 592,119 | 282,464 | -309,655 | 0.02 | 0.02 | -0.01 | sell |
| HSBC HOLDINGS PLC | 189,659 | 278,930 | +89,271 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 231,821 | 277,320 | +45,499 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 268,520 | 273,980 | +5,460 | 0.02 | 0.02 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Boxer Capital Management, LLC | 266,666 | 266,666 | 0 | 0.03 | 0.04 | +0.01 | hold |
| FRANKLIN RESOURCES INC | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 0 | 262,026 | +262,026 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 223,632 | 234,588 | +10,956 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 56,660 | 232,797 | +176,137 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 127,050 | 211,950 | +84,900 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 209,641 | +209,641 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 200,380 | 202,603 | +2,223 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 199,638 | +199,638 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 197,389 | 197,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 187,603 | 187,603 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALPS ADVISORS INC | 245,126 | 183,035 | -62,091 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 166,579 | 166,579 | 0 | 0.00 | 0.01 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 108,822 | 158,683 | +49,861 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 468,000 | 154,112 | -313,888 | 0.70 | 0.07 | -0.64 | sell |
| MetLife Investment Management, LLC | 89,335 | 154,029 | +64,694 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 153,756 | 153,756 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cresset Asset Management, LLC | 138,816 | 143,690 | +4,874 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 139,648 | +139,648 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 139,648 | +139,648 | 0.00 | 0.07 | +0.07 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 108,547 | 136,697 | +28,150 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 133,333 | 133,333 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 132,296 | +132,296 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 115,962 | 127,174 | +11,212 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 87,114 | 117,944 | +30,830 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 27,415 | 117,182 | +89,767 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 55,564 | 115,721 | +60,157 | 0.01 | 0.01 | +0.00 | buy |
| Palumbo Wealth Management LLC | 109,643 | 113,666 | +4,023 | 0.06 | 0.07 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 139,155 | 112,240 | -26,915 | 0.00 | 0.00 | -0.00 | sell |
| CROWLEY WEALTH MANAGEMENT, INC. | 7,000 | 106,798 | +99,798 | 0.01 | 0.19 | +0.18 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 106,020 | +106,020 | 0.00 | 0.00 | +0.00 | buy |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pale Fire Capital SE | 45,642 | 95,642 | +50,000 | 0.01 | 0.02 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 95,395 | +95,395 | 0.00 | 0.06 | +0.06 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,625 | 94,835 | -4,790 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,937 | 93,347 | +25,410 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 92,250 | +92,250 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Meridian Wealth Management, LLC | 82,335 | 87,115 | +4,780 | 0.01 | 0.01 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 85,300 | +85,300 | 0.00 | 0.16 | +0.16 | buy |
| DRW Securities, LLC | 0 | 84,246 | +84,246 | 0.00 | 0.01 | +0.01 | buy |
| WEXFORD CAPITAL LP | 772,919 | 81,590 | -691,329 | 0.35 | 0.04 | -0.31 | sell |
| JANUS HENDERSON GROUP PLC | 76,700 | 76,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 51,401 | 69,202 | +17,801 | 0.00 | 0.00 | +0.00 | buy |