| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Decheng Capital LLC | 6,950,239 | 25,954,439 | +19,004,200 | 6.22 | 14.08 | +7.86 | buy |
| Octagon Capital Advisors LP | 431,600 | 12,171,513 | +11,739,913 | 0.21 | 4.46 | +4.25 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,218,236 | +1,218,236 | 0.00 | 0.11 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 422,312 | 1,354,998 | +932,686 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,996,217 | 2,758,359 | +762,142 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 10,142,898 | 10,818,747 | +675,849 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,018,329 | 1,659,872 | +641,543 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 111,583 | 742,437 | +630,854 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 63,267 | 651,767 | +588,500 | 0.05 | 0.36 | +0.31 | buy |
| JPMORGAN CHASE & CO | 0 | 442,913 | +442,913 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 28,821,939 | 29,238,871 | +416,932 | 0.01 | 0.00 | -0.00 | buy |
| Octagon Capital Advisors LP | 0 | 312,336 | +312,336 | 0.00 | 0.11 | +0.11 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 340,331 | 623,973 | +283,642 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 276,714 | +276,714 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 761,000 | 1,029,000 | +268,000 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,267,315 | 1,523,124 | +255,809 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 230,997 | +230,997 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,832,445 | 4,028,692 | +196,247 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 3,975,410 | 4,166,441 | +191,031 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,139,506 | 1,324,170 | +184,664 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,751,864 | 3,900,000 | +148,136 | 1.12 | 0.64 | -0.48 | buy |
| MORGAN STANLEY | 1,038,686 | 1,182,871 | +144,185 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 132,029 | +132,029 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 727,728 | 831,544 | +103,816 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 243,358 | 341,547 | +98,189 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 98,947 | 195,131 | +96,184 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 95,725 | +95,725 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 82,447 | +82,447 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 79,922 | +79,922 | 0.00 | 0.10 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,069,801 | 1,145,331 | +75,530 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 74,932 | +74,932 | 0.00 | 0.01 | +0.01 | buy |
| Quantbot Technologies LP | 0 | 72,226 | +72,226 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 67,002 | +67,002 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 399,583 | 465,109 | +65,526 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,333,425 | 1,394,015 | +60,590 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 57,856 | +57,856 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 53,632 | +53,632 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 7,056 | 47,697 | +40,641 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 31,916 | 72,057 | +40,141 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 33,673 | +33,673 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 363,925 | 396,736 | +32,811 | 0.00 | 0.00 | -0.00 | buy |
| Meridian Wealth Management, LLC | 56,345 | 82,840 | +26,495 | 0.02 | 0.01 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 72,329 | 98,169 | +25,840 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 73,215 | 98,246 | +25,031 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 0 | 24,675 | +24,675 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 265,800 | 290,100 | +24,300 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 0 | 22,396 | +22,396 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 365,741 | 388,008 | +22,267 | 0.57 | 0.40 | -0.18 | buy |
| Legal & General Group Plc | 129,586 | 146,643 | +17,057 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 19,513 | 34,259 | +14,746 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 246,905 | 261,405 | +14,500 | 0.20 | 0.15 | -0.04 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 11,346 | +11,346 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 16,171 | 26,651 | +10,480 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 21,720 | 31,415 | +9,695 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 9,495 | +9,495 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 19,125 | 28,447 | +9,322 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 135,389 | 143,070 | +7,681 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 29,672 | 37,271 | +7,599 | 0.00 | 0.00 | -0.00 | buy |
| Cresset Asset Management, LLC | 127,150 | 134,290 | +7,140 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 361,406 | 367,942 | +6,536 | 0.00 | 0.00 | -0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 29,731 | 36,125 | +6,394 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 260,939 | 266,383 | +5,444 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 37,829 | 42,788 | +4,959 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 78,989 | 83,238 | +4,249 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1,094 | 5,291 | +4,197 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 14,367 | 17,567 | +3,200 | 0.00 | 0.00 | -0.00 | buy |
| Pallas Capital Advisors LLC | 13,357 | 15,934 | +2,577 | 0.00 | 0.00 | -0.00 | buy |
| Global Retirement Partners, LLC | 0 | 1,610 | +1,610 | 0.00 | 0.00 | +0.00 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 500 | 2,100 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 14,811 | 16,097 | +1,286 | 0.00 | 0.00 | -0.00 | buy |
| True Wealth Design, LLC | 0 | 561 | +561 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 30,276 | 30,821 | +545 | 0.04 | 0.03 | -0.01 | buy |
| SIGNATUREFD, LLC | 1,126 | 1,663 | +537 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 14,883 | 15,410 | +527 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 7,000 | 7,424 | +424 | 0.00 | 0.00 | -0.00 | buy |
| Corebridge Financial, Inc. | 96,552 | 96,943 | +391 | 0.00 | 0.00 | -0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 281 | +281 | 0.00 | 0.00 | +0.00 | buy |
| HHM Wealth Advisors, LLC | 0 | 128 | +128 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 16,070 | 16,083 | +13 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 197,389 | 197,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 156,675 | 156,675 | 0 | 0.03 | 0.02 | -0.01 | hold |
| PRUDENTIAL FINANCIAL INC | 12,215 | 12,215 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 76,700 | 76,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.26 | 0.23 | -0.03 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.22 | 0.14 | -0.08 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,050 | 43,050 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 166,579 | 166,579 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Laurion Capital Management LP | 1,591,475 | 1,591,475 | 0 | 0.15 | 0.23 | +0.08 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.54 | 0.41 | -0.13 | hold |
| B. Riley Wealth Advisors, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 668,115 | 668,115 | 0 | 0.74 | 0.69 | -0.05 | hold |
| DME Capital Management, LP | 34,995 | 34,995 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Arax Advisory Partners | 234 | 234 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.09 | 0.08 | -0.01 | hold |