| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 51,039,313 | 50,570,474 | -468,839 | 0.01 | 0.01 | +0.00 | sell |
| Decheng Capital LLC | 25,954,439 | 25,954,439 | 0 | 12.78 | 16.75 | +3.97 | hold |
| BlackRock, Inc. | 25,732,990 | 24,604,159 | -1,128,831 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 15,903,054 | 15,454,595 | -448,459 | 0.00 | 0.00 | +0.00 | sell |
| Laurion Capital Management LP | 10,240,706 | 9,705,532 | -535,174 | 2.30 | 4.90 | +2.59 | sell |
| Omega Fund Management, LLC | 11,042,728 | 8,831,089 | -2,211,639 | 13.94 | 14.69 | +0.75 | sell |
| STATE STREET CORP | 5,558,984 | 6,089,185 | +530,201 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,994,798 | 5,887,755 | -107,043 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 5,380,185 | 4,852,218 | -527,967 | 0.01 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 1,485,334 | 4,566,701 | +3,081,367 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,900,000 | 4,200,000 | +300,000 | 0.38 | 0.60 | +0.21 | buy |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.12 | 0.23 | +0.11 | hold |
| DIMENSIONAL FUND ADVISORS LP | 2,769,741 | 3,321,249 | +551,508 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.63 | 1.09 | +0.46 | hold |
| Aisling Capital Management LP | 2,541,009 | 2,960,659 | +419,650 | 1.38 | 2.40 | +1.02 | buy |
| Octagon Capital Advisors LP | 7,691,334 | 2,633,334 | -5,058,000 | 3.29 | 1.52 | -1.77 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,214,733 | 2,377,570 | +1,162,837 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 2,322,233 | +2,322,233 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 5,532,976 | 2,304,453 | -3,228,523 | 0.01 | 0.01 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 500,000 | 2,296,000 | +1,796,000 | 0.04 | 0.27 | +0.23 | buy |
| NORTHERN TRUST CORP | 2,084,167 | 2,117,672 | +33,505 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,130,899 | 2,055,495 | -75,404 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,137,292 | 2,034,211 | +896,919 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 95,642 | 1,444,647 | +1,349,005 | 0.02 | 0.59 | +0.57 | buy |
| MORGAN STANLEY | 1,209,803 | 1,319,495 | +109,692 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,478,044 | 1,202,616 | -275,428 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 1,627,122 | 1,035,192 | -591,930 | 0.22 | 0.32 | +0.10 | sell |
| Knoll Capital Management, LLC | 1,025,000 | 1,025,000 | 0 | 2.08 | 2.97 | +0.89 | hold |
| Palo Alto Investors LP | 772,652 | 1,020,547 | +247,895 | 0.32 | 0.70 | +0.38 | buy |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.11 | 0.17 | +0.06 | hold |
| Woodline Partners LP | 0 | 955,414 | +955,414 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 1,322,859 | 922,897 | -399,962 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 473,939 | 908,101 | +434,162 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 454,900 | 871,500 | +416,600 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 733,542 | 868,530 | +134,988 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 395,539 | 818,779 | +423,240 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 668,814 | 727,894 | +59,080 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 117,944 | 675,600 | +557,656 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 646,057 | 646,057 | 0 | 0.03 | 0.02 | -0.01 | hold |
| AMERICAN CENTURY COMPANIES INC | 547,929 | 633,708 | +85,779 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 631,154 | +631,154 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 209,641 | 629,162 | +419,521 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 393,414 | 497,546 | +104,132 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,019,565 | 495,934 | -523,631 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 463,996 | +463,996 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 689,855 | 370,861 | -318,994 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 426,700 | 361,800 | -64,900 | 0.00 | 0.00 | +0.00 | sell |
| Greenland Capital Management LP | 344,660 | 344,660 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Hennion & Walsh Asset Management, Inc. | 199,638 | 339,271 | +139,633 | 0.02 | 0.05 | +0.03 | buy |
| Intellectus Partners, LLC | 329,805 | 331,805 | +2,000 | 0.14 | 0.24 | +0.10 | buy |
| RHUMBLINE ADVISERS | 297,486 | 310,186 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 302,863 | +302,863 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 117,182 | 298,367 | +181,185 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 277,320 | 284,444 | +7,124 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Boxer Capital Management, LLC | 266,666 | 266,666 | 0 | 0.04 | 0.02 | -0.02 | hold |
| FRANKLIN RESOURCES INC | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROYAL BANK OF CANADA | 262,026 | 261,662 | -364 | 0.00 | 0.00 | +0.00 | sell |
| NEOS Investment Management LLC | 139,648 | 252,522 | +112,874 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 139,648 | 252,522 | +112,874 | 0.07 | 0.08 | +0.01 | buy |
| Legal & General Group Plc | 234,588 | 222,626 | -11,962 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 278,930 | 211,294 | -67,636 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 871,190 | 209,999 | -661,191 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 197,389 | 208,589 | +11,200 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 232,797 | 203,002 | -29,795 | 0.00 | 0.01 | +0.01 | sell |
| CAXTON ASSOCIATES LLP | 0 | 192,285 | +192,285 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 158,683 | 189,342 | +30,659 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 188,300 | +188,300 | 0.00 | 0.17 | +0.17 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 94,835 | 183,516 | +88,681 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 166,579 | 166,579 | 0 | 0.01 | 0.00 | -0.00 | hold |
| ALPS ADVISORS INC | 183,035 | 164,049 | -18,986 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 202,603 | 162,469 | -40,134 | 0.00 | 0.00 | +0.00 | sell |
| Beacon Pointe Advisors, LLC | 211,950 | 161,600 | -50,350 | 0.00 | 0.01 | +0.00 | sell |
| MetLife Investment Management, LLC | 154,029 | 147,861 | -6,168 | 0.00 | 0.00 | +0.00 | sell |
| Cresset Asset Management, LLC | 143,690 | 143,690 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 112,240 | 135,443 | +23,203 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palumbo Wealth Management LLC | 113,666 | 133,861 | +20,195 | 0.07 | 0.16 | +0.09 | buy |
| Samsara BioCapital, LLC | 133,333 | 133,333 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 0 | 124,437 | +124,437 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 95,395 | 117,610 | +22,215 | 0.06 | 0.17 | +0.11 | buy |
| SIMPLEX TRADING, LLC | 37,654 | 115,559 | +77,905 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 136,697 | 114,958 | -21,739 | 0.00 | 0.00 | +0.00 | sell |
| Meridian Wealth Management, LLC | 87,115 | 109,365 | +22,250 | 0.01 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 115,721 | 106,940 | -8,781 | 0.01 | 0.02 | +0.01 | sell |
| CROWLEY WEALTH MANAGEMENT, INC. | 106,798 | 106,798 | 0 | 0.19 | 0.31 | +0.12 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 106,020 | 106,020 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 0 | 105,812 | +105,812 | 0.00 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 154,112 | 104,112 | -50,000 | 0.07 | 0.06 | -0.01 | sell |
| CWM, LLC | 37,963 | 102,328 | +64,365 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 101,700 | +101,700 | 0.00 | 0.00 | +0.00 | buy |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Connective Capital Management, LLC | 0 | 99,623 | +99,623 | 0.00 | 0.34 | +0.34 | buy |
| Cerity Partners LLC | 49,818 | 97,883 | +48,065 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 127,174 | 97,817 | -29,357 | 0.00 | 0.00 | +0.00 | sell |
| Catalyst Funds Management Pty Ltd | 0 | 94,800 | +94,800 | 0.00 | 0.05 | +0.05 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.03 | 0.02 | -0.02 | hold |
| Man Group plc | 38,613 | 89,357 | +50,744 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 93,347 | 85,809 | -7,538 | 0.00 | 0.00 | +0.00 | sell |