| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 0 | 3,500,000 | +3,500,000 | 0.00 | 0.49 | +0.49 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,379,497 | 3,094,669 | +1,715,172 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 390,000 | 1,483,131 | +1,093,131 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,293 | 1,056,059 | +1,054,766 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 1,050,000 | 2,050,000 | +1,000,000 | 0.45 | 1.24 | +0.80 | buy |
| Octagon Capital Advisors LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.24 | +0.24 | buy |
| TWO SIGMA INVESTMENTS, LP | 622,259 | 1,512,369 | +890,110 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 0 | 802,544 | +802,544 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 113,717 | 645,804 | +532,087 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,449,856 | 2,977,302 | +527,446 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 231,379 | 738,831 | +507,452 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 67,971 | 514,930 | +446,959 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 734,700 | 1,146,900 | +412,200 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 102,309 | 486,752 | +384,443 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 412,553 | 794,108 | +381,555 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 322,118 | +322,118 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 95,606 | 381,319 | +285,713 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 238,079 | 482,970 | +244,891 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 238,330 | +238,330 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 26,574 | 244,240 | +217,666 | 0.01 | 0.08 | +0.07 | buy |
| JANE STREET GROUP, LLC | 10,014 | 173,551 | +163,537 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 154,083 | +154,083 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,900,122 | 3,046,325 | +146,203 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 316,499 | 460,471 | +143,972 | 0.25 | 0.35 | +0.10 | buy |
| HRT FINANCIAL LP | 11,819 | 154,066 | +142,247 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 124,607 | +124,607 | 0.00 | 0.07 | +0.07 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 116,748 | +116,748 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,042,153 | 1,126,663 | +84,510 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 15,749 | 90,604 | +74,855 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 65,390 | 111,759 | +46,369 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 3,029,145 | 3,062,214 | +33,069 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 32,723 | +32,723 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 80,497 | 107,843 | +27,346 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 47,944 | 74,228 | +26,284 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 0 | 21,700 | +21,700 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 7,296,158 | 7,314,615 | +18,457 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 276,174 | 293,703 | +17,529 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 16,052 | +16,052 | 0.00 | 0.00 | +0.00 | buy |
| Gladius Capital Management LP | 16,082 | 30,967 | +14,885 | 0.01 | 0.03 | +0.02 | buy |
| Invesco Ltd. | 221,785 | 233,122 | +11,337 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 36,013 | 44,871 | +8,858 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 7,066 | +7,066 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 32,553 | 38,079 | +5,526 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 18,925 | 24,111 | +5,186 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 26,287 | 30,732 | +4,445 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 3,963 | +3,963 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,880 | 19,374 | +3,494 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 3,474 | +3,474 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 516,604 | 518,104 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 1,126 | +1,126 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 37,645 | 38,661 | +1,016 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 44 | 266 | +222 | 0.00 | 0.00 | 0.00 | buy |
| HSBC HOLDINGS PLC | 174,827 | 174,944 | +117 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 15,419 | 15,419 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 61,091 | 61,091 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 14,367 | 14,367 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 118,057 | 118,057 | 0 | 0.03 | 0.03 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 64,304 | 64,304 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 162,257 | 162,257 | 0 | 0.01 | 0.02 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.17 | 0.18 | +0.01 | hold |
| 683 Capital Management, LLC | 835,323 | 835,323 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.19 | 0.16 | -0.03 | hold |
| Ensign Peak Advisors, Inc | 63,763 | 63,763 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 79,288 | 79,288 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 261,390 | 261,390 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.01 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.04 | 0.04 | -0.01 | hold |
| EcoR1 Capital, LLC | 19,209,643 | 19,209,643 | 0 | 0.88 | 0.75 | -0.12 | hold |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tortoise Investment Management, LLC | 13,752 | 13,752 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clearline Capital LP | 494,506 | 494,506 | 0 | 0.07 | 0.08 | +0.02 | hold |
| Omega Fund Management, LLC | 15,072,340 | 15,072,340 | 0 | 18.55 | 18.44 | -0.11 | hold |
| EverSource Wealth Advisors, LLC | 1,095 | 1,095 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Samsara BioCapital, LLC | 133,333 | 133,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aisling Capital Management LP | 2,541,009 | 2,541,009 | 0 | 1.40 | 1.14 | -0.26 | hold |
| Affinity Asset Advisors, LLC | 250,000 | 250,000 | 0 | 0.11 | 0.08 | -0.03 | hold |
| Ikarian Capital, LLC | 1,222,852 | 1,222,852 | 0 | 0.61 | 0.51 | -0.10 | hold |
| Avidity Partners Management LP | 89,543 | 89,543 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Logos Global Management LP | 66,666 | 66,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hunter Perkins Capital Management, LLC | 23,000 | 23,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BARCLAYS PLC | 1,638 | 1,638 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 42,238 | 42,238 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 266,666 | 266,666 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 36,900 | 36,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 41,690 | 41,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 178 | 0 | -178 | 0.00 | 0.00 | 0.00 | sell |
| Pallas Capital Advisors LLC | 10,284 | 10,000 | -284 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 48,457 | 48,172 | -285 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 72,703 | 72,411 | -292 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 410 | 0 | -410 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 99,503 | 98,865 | -638 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 128,213 | 127,050 | -1,163 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 14,182 | 12,980 | -1,202 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,470 | 0 | -1,470 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 6,404 | 3,904 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 20,451 | 17,545 | -2,906 | 0.00 | 0.00 | -0.00 | sell |