| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 29,238,871 | 45,285,572 | +16,046,701 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 10,818,747 | 15,732,567 | +4,913,820 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 1,591,475 | 6,491,475 | +4,900,000 | 0.23 | 1.07 | +0.84 | buy |
| MPM BioImpact LLC | 0 | 4,164,178 | +4,164,178 | 0.00 | 1.57 | +1.57 | buy |
| BlackRock, Inc. | 16,973,997 | 18,541,780 | +1,567,783 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 465,109 | 1,850,693 | +1,385,584 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,354,998 | 2,475,872 | +1,120,874 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,028,692 | 4,951,195 | +922,503 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,324,170 | 2,029,774 | +705,604 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 288,189 | 871,469 | +583,280 | 0.02 | 0.05 | +0.04 | buy |
| NORTHERN TRUST CORP | 1,523,124 | 2,086,751 | +563,627 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,394,015 | 1,945,983 | +551,968 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,166,441 | 4,599,993 | +433,552 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 651,767 | 946,219 | +294,452 | 0.36 | 0.64 | +0.29 | buy |
| ALPS ADVISORS INC | 0 | 272,150 | +272,150 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 13,375 | 214,155 | +200,780 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 74,932 | 242,253 | +167,321 | 0.01 | 0.05 | +0.03 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 76,494 | 215,198 | +138,704 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 290,100 | 426,700 | +136,600 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 225,619 | 347,806 | +122,187 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 742,437 | 821,359 | +78,922 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 146,643 | 224,827 | +78,184 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 341,547 | 411,173 | +69,626 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 66,666 | +66,666 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,218,321 | 1,279,712 | +61,391 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 143,070 | 200,380 | +57,310 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 98,169 | 155,100 | +56,931 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 0 | 53,550 | +53,550 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 623,973 | 676,024 | +52,051 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 16,446 | 65,360 | +48,914 | 0.01 | 0.06 | +0.05 | buy |
| Pale Fire Capital SE | 0 | 39,000 | +39,000 | 0.00 | 0.02 | +0.02 | buy |
| IEQ CAPITAL, LLC | 0 | 36,993 | +36,993 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 33,671 | +33,671 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 31,431 | +31,431 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 37,271 | 64,502 | +27,231 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 117,353 | 143,223 | +25,870 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 396,736 | 422,260 | +25,524 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 24,031 | +24,031 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 83,238 | 106,416 | +23,178 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 831,544 | 852,755 | +21,211 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 42,788 | 62,964 | +20,176 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 20,166 | +20,166 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 261,405 | 280,905 | +19,500 | 0.15 | 0.17 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 57,856 | 76,506 | +18,650 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 16,967 | +16,967 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 34,259 | 51,060 | +16,801 | 0.00 | 0.00 | +0.00 | buy |
| Abacus Planning Group, Inc. | 0 | 16,611 | +16,611 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 104 | 15,895 | +15,791 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 504,372 | 518,575 | +14,203 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 91,051 | 103,647 | +12,596 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 11,809 | +11,809 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 11,711 | +11,711 | 0.00 | 0.00 | +0.00 | buy |
| Forum Financial Management, LP | 0 | 10,840 | +10,840 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 10,140 | +10,140 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 215,267 | 225,025 | +9,758 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 20,898 | 28,339 | +7,441 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 323,044 | 330,388 | +7,344 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5,291 | 12,091 | +6,800 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 24,675 | 31,348 | +6,673 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,145,331 | 1,151,256 | +5,925 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 98,246 | 103,939 | +5,693 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 627 | 5,807 | +5,180 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 47,697 | 52,737 | +5,040 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 96,360 | 101,375 | +5,015 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 4,500 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 72,057 | 75,855 | +3,798 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 16,083 | 19,011 | +2,928 | 0.00 | 0.00 | +0.00 | buy |
| Kohmann Bosshard Financial Services, LLC | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 134,290 | 136,435 | +2,145 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Management, LLC | 82,840 | 84,840 | +2,000 | 0.01 | 0.01 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 15,410 | 17,070 | +1,660 | 0.00 | 0.00 | +0.00 | buy |
| CLEAR STREET LLC | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 11,351 | 12,443 | +1,092 | 0.00 | 0.00 | +0.00 | buy |
| Pallas Capital Advisors LLC | 15,934 | 17,016 | +1,082 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 1,016 | +1,016 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 144 | 830 | +686 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,241 | 2,871 | +630 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 11,095 | 11,424 | +329 | 0.00 | 0.00 | +0.00 | buy |
| CHOREO, LLC | 16,097 | 16,420 | +323 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 0 | 270 | +270 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 20,885 | 21,010 | +125 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 83,282 | 83,407 | +125 | 0.06 | 0.06 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| HHM Wealth Advisors, LLC | 128 | 138 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 34 | 36 | +2 | 0.00 | 0.00 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 17,567 | 17,567 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 197,389 | 197,389 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 12,215 | 12,215 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SHELL ASSET MANAGEMENT CO | 30,087 | 30,087 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 3,900,000 | 3,900,000 | 0 | 0.64 | 0.69 | +0.05 | hold |
| JANUS HENDERSON GROUP PLC | 76,700 | 76,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.23 | 0.32 | +0.09 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.14 | 0.16 | +0.02 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,050 | 43,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Laurion Capital Management LP | 166,579 | 166,579 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marquette Asset Management, LLC | 56,114 | 56,114 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.41 | 0.56 | +0.15 | hold |