| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 29,238,871 | 45,285,572 | +16,046,701 | 0.00 | 0.01 | +0.00 | buy |
| Decheng Capital LLC | 25,954,439 | 25,954,439 | 0 | 14.08 | 14.81 | +0.73 | hold |
| BlackRock, Inc. | 16,973,997 | 18,541,780 | +1,567,783 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 10,818,747 | 15,732,567 | +4,913,820 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 13,072,340 | 13,072,340 | 0 | 18.71 | 22.55 | +3.84 | hold |
| Octagon Capital Advisors LP | 12,171,513 | 9,202,907 | -2,968,606 | 4.46 | 4.16 | -0.30 | sell |
| Laurion Capital Management LP | 1,591,475 | 6,491,475 | +4,900,000 | 0.23 | 1.07 | +0.84 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,028,692 | 4,951,195 | +922,503 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,166,441 | 4,599,993 | +433,552 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 4,164,178 | +4,164,178 | 0.00 | 1.57 | +1.57 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,900,000 | 3,900,000 | 0 | 0.64 | 0.69 | +0.05 | hold |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | 3,811,513 | 0 | 0.14 | 0.16 | +0.02 | hold |
| Redmile Group, LLC | 3,031,009 | 3,031,009 | 0 | 0.41 | 0.56 | +0.15 | hold |
| Aisling Capital Management LP | 2,541,009 | 2,541,009 | 0 | 2.23 | 2.40 | +0.17 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,354,998 | 2,475,872 | +1,120,874 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,758,359 | 2,177,962 | -580,397 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,523,124 | 2,086,751 | +563,627 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,324,170 | 2,029,774 | +705,604 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,394,015 | 1,945,983 | +551,968 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 465,109 | 1,850,693 | +1,385,584 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,218,321 | 1,279,712 | +61,391 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,659,872 | 1,227,152 | -432,720 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,145,331 | 1,151,256 | +5,925 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,182,871 | 1,072,836 | -110,035 | 0.00 | 0.00 | +0.00 | sell |
| EcoR1 Capital, LLC | 963,333 | 963,333 | 0 | 0.08 | 0.10 | +0.03 | hold |
| WEXFORD CAPITAL LP | 651,767 | 946,219 | +294,452 | 0.36 | 0.64 | +0.29 | buy |
| ALGERT GLOBAL LLC | 288,189 | 871,469 | +583,280 | 0.02 | 0.05 | +0.04 | buy |
| CITIGROUP INC | 831,544 | 852,755 | +21,211 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 742,437 | 821,359 | +78,922 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 772,652 | 772,652 | 0 | 0.23 | 0.32 | +0.09 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 623,973 | 676,024 | +52,051 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 668,115 | 668,115 | 0 | 0.69 | 0.50 | -0.19 | hold |
| Decheng Capital LLC | 646,057 | 646,057 | 0 | 0.01 | 0.03 | +0.02 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,029,000 | 566,800 | -462,200 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 504,372 | 518,575 | +14,203 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 495,775 | 495,675 | -100 | 0.00 | 0.01 | +0.01 | sell |
| TWO SIGMA ADVISERS, LP | 533,900 | 476,400 | -57,500 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 290,100 | 426,700 | +136,600 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 396,736 | 422,260 | +25,524 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 341,547 | 411,173 | +69,626 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 225,619 | 347,806 | +122,187 | 0.00 | 0.00 | +0.00 | buy |
| Greenland Capital Management LP | 344,660 | 344,660 | 0 | 0.01 | 0.02 | +0.01 | hold |
| PANAGORA ASSET MANAGEMENT INC | 605,472 | 341,763 | -263,709 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 323,044 | 330,388 | +7,344 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 312,336 | 312,336 | 0 | 0.11 | 0.14 | +0.03 | hold |
| Intellectus Partners, LLC | 261,405 | 280,905 | +19,500 | 0.15 | 0.17 | +0.01 | buy |
| ALPS ADVISORS INC | 0 | 272,150 | +272,150 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 266,666 | 266,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 266,383 | 263,805 | -2,578 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 74,932 | 242,253 | +167,321 | 0.01 | 0.05 | +0.03 | buy |
| Point72 Asset Management, L.P. | 276,714 | 226,824 | -49,890 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 215,267 | 225,025 | +9,758 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 146,643 | 224,827 | +78,184 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 76,494 | 215,198 | +138,704 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 13,375 | 214,155 | +200,780 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 143,070 | 200,380 | +57,310 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 197,389 | 197,389 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 268,970 | 177,233 | -91,737 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Laurion Capital Management LP | 166,579 | 166,579 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 98,169 | 155,100 | +56,931 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 153,756 | 153,756 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 117,353 | 143,223 | +25,870 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 134,290 | 136,435 | +2,145 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 134,028 | 134,028 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 133,333 | 133,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Assenagon Asset Management S.A. | 438,539 | 129,363 | -309,176 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 442,913 | 120,115 | -322,798 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 230,997 | 109,011 | -121,986 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 83,238 | 106,416 | +23,178 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 98,246 | 103,939 | +5,693 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 91,051 | 103,647 | +12,596 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 156,675 | 101,561 | -55,114 | 0.02 | 0.01 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 96,360 | 101,375 | +5,015 | 0.00 | 0.00 | +0.00 | buy |
| DME Capital Management, LP | 100,000 | 100,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 90,832 | 90,832 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Corebridge Financial, Inc. | 96,943 | 90,139 | -6,804 | 0.00 | 0.00 | +0.00 | sell |
| Meridian Wealth Management, LLC | 82,840 | 84,840 | +2,000 | 0.01 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 83,282 | 83,407 | +125 | 0.06 | 0.06 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 82,447 | 77,280 | -5,167 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 76,700 | 76,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 57,856 | 76,506 | +18,650 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 72,057 | 75,855 | +3,798 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,230 | 68,040 | -1,190 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 0 | 66,666 | +66,666 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 16,446 | 65,360 | +48,914 | 0.01 | 0.06 | +0.05 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 37,271 | 64,502 | +27,231 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 42,788 | 62,964 | +20,176 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 58,751 | 58,551 | -200 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 60,337 | 56,524 | -3,813 | 0.00 | 0.00 | +0.00 | sell |
| Marquette Asset Management, LLC | 56,114 | 56,114 | 0 | 0.02 | 0.02 | +0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 54,548 | 54,548 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Beacon Pointe Advisors, LLC | 0 | 53,550 | +53,550 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 47,697 | 52,737 | +5,040 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 34,259 | 51,060 | +16,801 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 48,128 | 48,128 | 0 | 0.00 | 0.00 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 111,227 | 47,400 | -63,827 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,050 | 43,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 41,690 | 41,690 | 0 | 0.00 | 0.00 | +0.00 | hold |