| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Knoll Capital Management, LLC | 1,025,000 | 1,498,591 | +473,591 | 2.97 | 6.16 | +3.19 | buy |
| CAXTON ASSOCIATES LLP | 192,285 | 584,935 | +392,650 | 0.02 | 0.10 | +0.09 | buy |
| Quarry LP | 188,300 | 40,000 | +148,300 | 0.18 | 0.06 | 0.00 | sell |
| Redmile Group, LLC | 3,031,009 | 3,163,256 | +132,247 | 1.09 | 2.09 | +1.00 | buy |
| ALPS ADVISORS INC | 164,049 | 280,900 | +116,851 | 0.00 | 0.01 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 339,271 | 445,279 | +106,008 | 0.05 | 0.14 | +0.09 | buy |
| WEXFORD CAPITAL LP | 30,328 | 130,000 | +99,672 | 0.02 | 0.22 | +0.21 | buy |
| Palumbo Wealth Management LLC | 133,861 | 163,756 | +29,895 | 0.16 | 0.36 | +0.20 | buy |
| PROFUND ADVISORS LLC | 58,990 | 36,520 | +22,470 | 0.01 | 0.01 | 0.00 | sell |
| Virtus Investment Advisers, LLC | 62,866 | 81,068 | +18,202 | 0.07 | 0.20 | +0.13 | buy |
| Intellectus Partners, LLC | 26,396 | 32,298 | +5,902 | 0.00 | 0.00 | +0.00 | buy |
| Greenland Capital Management LP | 344,660 | 348,960 | +4,300 | 0.01 | 0.02 | +0.01 | buy |
| Meridian Wealth Management, LLC | 109,365 | 113,565 | +4,200 | 0.02 | 0.04 | +0.02 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 21,730 | 22,671 | +941 | 0.00 | 0.01 | +0.00 | buy |
| TFC Financial Management, Inc. | 1,000 | 1,050 | +50 | 0.00 | 0.00 | +0.00 | buy |
| LCM Capital Management Inc | 15,500 | 15,000 | -500 | 0.03 | 0.06 | +0.04 | sell |
| NEOS Investment Management LLC | 252,522 | 247,508 | -5,014 | 0.01 | 0.01 | +0.01 | sell |
| TEMA ETFS LLC | 252,522 | 243,848 | -8,674 | 0.08 | 0.17 | +0.09 | sell |
| Samsara BioCapital, LLC | 133,333 | 124,119 | -9,214 | 0.00 | 0.00 | +0.00 | sell |
| Hunter Perkins Capital Management, LLC | 22,500 | 10,200 | -12,300 | 0.02 | 0.02 | +0.00 | sell |
| Intellectus Partners, LLC | 331,805 | 285,417 | -46,388 | 0.24 | 0.49 | +0.26 | sell |
| AXQ CAPITAL, LP | 117,610 | 11,649 | -105,961 | 0.17 | 0.02 | -0.14 | sell |
| TANG CAPITAL MANAGEMENT LLC | 4,200,000 | 3,857,457 | -342,543 | 0.60 | 1.71 | +1.11 | sell |
| Palo Alto Investors LP | 1,020,547 | 538,079 | -482,468 | 0.70 | 0.67 | -0.03 | sell |
| Omega Fund Management, LLC | 8,831,089 | 8,081,089 | -750,000 | 14.69 | 25.27 | +10.58 | sell |
| ARMISTICE CAPITAL, LLC | 2,296,000 | 1,263,737 | -1,032,263 | 0.13 | 0.13 | +0.01 | sell |
| Laurion Capital Management LP | 9,705,532 | 7,852,638 | -1,852,894 | 0.62 | 2.62 | +2.00 | sell |