| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 9,751,141 | 14,106,187 | +4,355,046 | 1.90 | 3.96 | +2.07 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 2,826,783 | +1,666,666 | 0.07 | 0.27 | +0.20 | buy |
| Casdin Capital, LLC | 14,418,574 | 16,035,240 | +1,616,666 | 10.86 | 15.02 | +4.15 | buy |
| Nextech Invest, Ltd. | 5,526,506 | 6,776,506 | +1,250,000 | 3.87 | 6.02 | +2.15 | buy |
| TFG Asset Management GP Ltd | 181,543 | 570,311 | +388,768 | 0.35 | 1.68 | +1.33 | buy |
| Foresite Capital Management IV, LLC | 1,000,000 | 1,250,000 | +250,000 | 4.20 | 8.06 | +3.86 | buy |
| Rhenman & Partners Asset Management AB | 360,000 | 566,000 | +206,000 | 0.44 | 1.00 | +0.56 | buy |
| Eversept Partners, LP | 270,705 | 434,314 | +163,609 | 0.14 | 0.42 | +0.28 | buy |
| HighVista Strategies LLC | 421,881 | 506,235 | +84,354 | 1.16 | 2.16 | +1.00 | buy |
| MPM BioImpact LLC | 2,359,586 | 2,415,672 | +56,086 | 1.81 | 2.76 | +0.94 | buy |
| TEMA ETFS LLC | 154,100 | 176,782 | +22,682 | 0.10 | 0.11 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 618,938 | 626,141 | +7,203 | 0.04 | 0.07 | +0.03 | buy |
| Duncan Williams Asset Management, LLC | 11,438 | 13,876 | +2,438 | 0.03 | 0.06 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 31,716 | 34,138 | +2,422 | 0.02 | 0.04 | +0.01 | buy |
| Abel Hall, LLC | 18,237 | 18,362 | +125 | 0.04 | 0.06 | +0.02 | buy |
| Valeo Financial Advisors, LLC | 35,714 | 35,687 | -27 | 0.01 | 0.01 | +0.01 | sell |
| J. Goldman & Co LP | 63,637 | 56,569 | -7,068 | 0.02 | 0.03 | +0.01 | sell |
| Intellectus Partners, LLC | 42,225 | 20,225 | -22,000 | 0.09 | 0.07 | -0.02 | sell |
| Headlands Technologies LLC | 47,626 | 22,073 | -25,553 | 0.05 | 0.04 | -0.01 | sell |
| Alphabet Inc. | 1,564,173 | 1,410,029 | -154,144 | 0.39 | 0.03 | -0.36 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 408,436 | 233,836 | -174,600 | 0.65 | 0.57 | -0.07 | sell |
| EcoR1 Capital, LLC | 1,904,762 | 697,948 | -1,206,814 | 0.80 | 0.63 | -0.17 | sell |
| Bellevue Group AG | 7,795,242 | 6,185,970 | -1,609,272 | 1.85 | 2.44 | +0.59 | sell |