| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 2.73 | 2.29 | -0.45 | hold |
| VANGUARD GROUP INC | 10,650,387 | 11,815,669 | +1,165,282 | 0.00 | 0.00 | -0.00 | buy |
| Casdin Capital, LLC | 7,387,943 | 7,423,574 | +35,631 | 8.02 | 4.59 | -3.43 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,581,167 | 6,879,597 | -1,701,570 | 0.01 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 4,903,578 | 6,020,988 | +1,117,410 | 0.00 | 0.00 | -0.00 | buy |
| Bellevue Group AG | 5,936,082 | 5,926,618 | -9,464 | 1.00 | 0.75 | -0.25 | sell |
| ArrowMark Colorado Holdings LLC | 3,914,246 | 4,005,170 | +90,924 | 0.48 | 0.37 | -0.10 | buy |
| BRAIDWELL LP | 0 | 3,743,999 | +3,743,999 | 0.00 | 1.00 | +1.00 | buy |
| JPMORGAN CHASE & CO | 6,065,595 | 3,717,268 | -2,348,327 | 0.01 | 0.00 | -0.00 | sell |
| NORGES BANK | 3,068,973 | 3,392,625 | +323,652 | 0.01 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,081,510 | 2,216,793 | +135,283 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 983,387 | 1,763,148 | +779,761 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,684,299 | 1,675,403 | -8,896 | 0.09 | 0.06 | -0.03 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,359,155 | 1,600,814 | +241,659 | 0.00 | 0.00 | -0.00 | buy |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.80 | 0.52 | -0.28 | hold |
| Finepoint Capital LP | 1,317,870 | 1,490,170 | +172,300 | 5.02 | 3.17 | -1.85 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.15 | 0.12 | -0.02 | hold |
| MORGAN STANLEY | 728,704 | 1,157,021 | +428,317 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,454,943 | 1,086,089 | -368,854 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 999,639 | +999,639 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 0 | 952,019 | +952,019 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 877,813 | 912,157 | +34,344 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 832,017 | 832,017 | 0 | 2.14 | 1.11 | -1.03 | hold |
| NORTHERN TRUST CORP | 824,350 | 828,407 | +4,057 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 323,700 | 763,200 | +439,500 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 312,190 | 741,703 | +429,513 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 600,000 | 725,000 | +125,000 | 0.95 | 0.59 | -0.36 | buy |
| TWO SIGMA INVESTMENTS, LP | 404,916 | 587,690 | +182,774 | 0.01 | 0.01 | +0.00 | buy |
| BESSEMER GROUP INC | 584,463 | 584,463 | 0 | 0.01 | 0.01 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 841,866 | 557,296 | -284,570 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 138,281 | 538,603 | +400,322 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 721,070 | 508,429 | -212,641 | 0.05 | 0.03 | -0.03 | sell |
| Rafferty Asset Management, LLC | 327,548 | 464,060 | +136,512 | 0.02 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 459,543 | 450,172 | -9,371 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 0 | 450,000 | +450,000 | 0.00 | 1.04 | +1.04 | buy |
| CITIGROUP INC | 146,263 | 414,977 | +268,714 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 593,002 | 397,918 | -195,084 | 0.08 | 0.03 | -0.05 | sell |
| TWO SIGMA ADVISERS, LP | 329,600 | 394,300 | +64,700 | 0.01 | 0.01 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 362,450 | +362,450 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 467,966 | 358,656 | -109,310 | 0.01 | 0.00 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 373,596 | 353,226 | -20,370 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 0 | 336,490 | +336,490 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 322,061 | 306,448 | -15,613 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 232,141 | 301,935 | +69,794 | 0.10 | 0.10 | -0.00 | buy |
| HARBOURVEST PARTNERS LLC | 296,402 | 296,402 | 0 | 1.09 | 1.12 | +0.03 | hold |
| UBS Group AG | 186,299 | 287,926 | +101,627 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 250,000 | 273,008 | +23,008 | 0.03 | 0.02 | -0.01 | buy |
| HighTower Advisors, LLC | 212,791 | 247,291 | +34,500 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 597,594 | 237,200 | -360,394 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 239,056 | 235,186 | -3,870 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 390,000 | 230,000 | -160,000 | 0.43 | 0.18 | -0.25 | sell |
| MILLENNIUM MANAGEMENT LLC | 186,966 | 227,906 | +40,940 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 210,003 | 208,356 | -1,647 | 0.04 | 0.04 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 226,312 | 206,756 | -19,556 | 0.01 | 0.01 | -0.00 | sell |
| Man Group plc | 57,347 | 187,982 | +130,635 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 114,488 | 179,972 | +65,484 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 156,400 | 163,500 | +7,100 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 151,445 | 156,387 | +4,942 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 153,769 | +153,769 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 194,889 | 152,991 | -41,898 | 0.24 | 0.12 | -0.12 | sell |
| BIT Capital GmbH | 0 | 152,439 | +152,439 | 0.00 | 0.11 | +0.11 | buy |
| AMERICAN CENTURY COMPANIES INC | 87,272 | 149,194 | +61,922 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 146,974 | 149,082 | +2,108 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 53,238 | 141,439 | +88,201 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 294,785 | 139,996 | -154,789 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 34,962 | 137,434 | +102,472 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 118,644 | +118,644 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 147,081 | 116,883 | -30,198 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 209,263 | 101,563 | -107,700 | 0.04 | 0.02 | -0.02 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 133,733 | 100,039 | -33,694 | 0.05 | 0.02 | -0.02 | sell |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.02 | 0.01 | -0.01 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 98,413 | 94,341 | -4,072 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 75,799 | 87,087 | +11,288 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,535 | 84,013 | -1,522 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 13,380 | 81,295 | +67,915 | 0.03 | 0.12 | +0.09 | buy |
| PROFUND ADVISORS LLC | 54,029 | 72,349 | +18,320 | 0.03 | 0.02 | -0.00 | buy |
| Intellectus Partners, LLC | 49,860 | 69,260 | +19,400 | 0.16 | 0.15 | -0.01 | buy |
| DekaBank Deutsche Girozentrale | 68,937 | 68,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 11,467 | 68,859 | +57,392 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 31,314 | 65,441 | +34,127 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,638 | 63,720 | +26,082 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 97,386 | 58,353 | -39,033 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 46,696 | 57,826 | +11,130 | 0.01 | 0.01 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 51,233 | 54,917 | +3,684 | 0.00 | 0.00 | +0.00 | buy |
| TrueMark Investments, LLC | 47,958 | 54,445 | +6,487 | 0.52 | 0.41 | -0.11 | buy |
| M&T BANK CORP | 54,285 | 54,250 | -35 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 101,161 | 53,414 | -47,747 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 50,367 | 51,615 | +1,248 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 27,114 | 49,374 | +22,260 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 44,876 | 46,686 | +1,810 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 46,053 | 46,053 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SHERBROOKE PARK ADVISERS LLC | 0 | 44,692 | +44,692 | 0.00 | 0.07 | +0.07 | buy |
| Dynamic Technology Lab Private Ltd | 20,763 | 44,632 | +23,869 | 0.02 | 0.04 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 46,850 | 44,600 | -2,250 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 66,336 | 43,382 | -22,954 | 0.00 | 0.00 | -0.00 | sell |
| Pennant Investors, LP | 42,400 | 42,400 | 0 | 0.14 | 0.10 | -0.05 | hold |
| Handelsbanken Fonder AB | 29,500 | 39,200 | +9,700 | 0.00 | 0.00 | -0.00 | buy |
| Bayesian Capital Management, LP | 0 | 38,600 | +38,600 | 0.00 | 0.03 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 37,313 | 37,342 | +29 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,678 | 36,678 | 0 | 0.00 | 0.00 | -0.00 | hold |