| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 1,592,753 | 10,827,067 | +9,234,314 | 0.02 | 0.08 | +0.06 | buy |
| Kynam Capital Management, LP | 1,000,000 | 3,063,292 | +2,063,292 | 0.27 | 0.69 | +0.41 | buy |
| Woodline Partners LP | 276,904 | 1,518,561 | +1,241,657 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,549,190 | 2,276,110 | +726,920 | 0.01 | 0.01 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 28,947 | 682,028 | +653,081 | 0.00 | 0.01 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 619,000 | +619,000 | 0.00 | 0.52 | +0.52 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 405,995 | +405,995 | 0.00 | 0.05 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,568,384 | 2,942,875 | +374,491 | 0.01 | 0.01 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 368,579 | +368,579 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,300,770 | 1,593,186 | +292,416 | 0.00 | 0.00 | -0.00 | buy |
| CW Advisors, LLC | 0 | 186,063 | +186,063 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,318 | 256,783 | +180,465 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,321,741 | 3,477,791 | +156,050 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 313,202 | 469,171 | +155,969 | 0.00 | 0.00 | -0.00 | buy |
| Casdin Capital, LLC | 8,948,574 | 9,098,574 | +150,000 | 2.47 | 1.95 | -0.52 | buy |
| TWO SIGMA ADVISERS, LP | 638,900 | 751,200 | +112,300 | 0.01 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 58,805 | 171,080 | +112,275 | 0.00 | 0.00 | +0.00 | buy |
| Private Capital Advisors, Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 457,294 | 554,428 | +97,134 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 85,200 | +85,200 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 71,649 | +71,649 | 0.00 | 0.05 | +0.05 | buy |
| Polymer Capital Management (US) LLC | 0 | 69,404 | +69,404 | 0.00 | 0.05 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 232,582 | 301,550 | +68,968 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 305,441 | 372,353 | +66,912 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 119,417 | 184,831 | +65,414 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 56,334 | +56,334 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 205,676 | 260,313 | +54,637 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,010,807 | 1,064,858 | +54,051 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 330,699 | 382,900 | +52,201 | 0.03 | 0.02 | -0.01 | buy |
| Ikarian Capital, LLC | 693,308 | 743,308 | +50,000 | 0.82 | 0.63 | -0.18 | buy |
| Savant Capital, LLC | 29,088 | 78,814 | +49,726 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 22,325 | 71,486 | +49,161 | 0.04 | 0.09 | +0.05 | buy |
| Verition Fund Management LLC | 90,474 | 139,244 | +48,770 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 199,743 | 247,176 | +47,433 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 46,548 | +46,548 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 50,100 | 96,313 | +46,213 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 43,735 | +43,735 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,030,157 | 3,070,118 | +39,961 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 326,134 | 364,946 | +38,812 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 272,166 | 308,752 | +36,586 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 75,510 | 111,472 | +35,962 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 34,345 | +34,345 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 47,645 | 81,428 | +33,783 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 67,178 | 100,555 | +33,377 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 173,605 | 205,721 | +32,116 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 31,778 | +31,778 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 138,281 | 168,281 | +30,000 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 29,438 | +29,438 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 0 | 29,379 | +29,379 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 816,085 | 843,856 | +27,771 | 0.01 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 2,268,825 | 2,295,924 | +27,099 | 1.33 | 1.03 | -0.29 | buy |
| Arkadios Wealth Advisors | 0 | 25,669 | +25,669 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 25,630 | +25,630 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 64,655 | 89,110 | +24,455 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 64,655 | 89,110 | +24,455 | 0.11 | 0.07 | -0.04 | buy |
| Allspring Global Investments Holdings, LLC | 41,299 | 63,606 | +22,307 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 59,752 | 79,913 | +20,161 | 0.02 | 0.01 | -0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 20,067 | +20,067 | 0.00 | 0.01 | +0.01 | buy |
| CIBC WORLD MARKETS CORP | 11,388 | 27,917 | +16,529 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 4,325 | 20,269 | +15,944 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 20,649 | 36,293 | +15,644 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 15,472 | +15,472 | 0.00 | 0.00 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 12,650 | +12,650 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 52,770 | 65,340 | +12,570 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 214,399 | 226,737 | +12,338 | 0.03 | 0.02 | -0.01 | buy |
| AssuredPartners Investment Advisors, LLC | 0 | 11,229 | +11,229 | 0.00 | 0.01 | +0.01 | buy |
| DRW Securities, LLC | 0 | 10,757 | +10,757 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 10,100 | +10,100 | 0.00 | 0.01 | +0.01 | buy |
| Murchinson Ltd. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 346,288 | 356,165 | +9,877 | 0.02 | 0.02 | -0.01 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 68,937 | +8,937 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 219,600 | 227,000 | +7,400 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 78,831 | 84,069 | +5,238 | 0.00 | 0.00 | -0.00 | buy |
| FNY Investment Advisers, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 4,663 | +4,663 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 111,769 | 116,408 | +4,639 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 124,886 | 129,215 | +4,329 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 71,425 | 75,514 | +4,089 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,150 | 4,784 | +3,634 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 2,801 | 6,055 | +3,254 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 445 | 3,417 | +2,972 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 171,444 | 174,125 | +2,681 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 17,654 | 19,165 | +1,511 | 0.00 | 0.00 | -0.00 | buy |
| Versant Capital Management, Inc | 0 | 1,458 | +1,458 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 60,500 | 61,637 | +1,137 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 328,897 | 329,905 | +1,008 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 160 | 1,128 | +968 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 63 | 940 | +877 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 3,355 | 4,200 | +845 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 97 | 929 | +832 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 32,737 | 33,557 | +820 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,515 | 4,286 | +771 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 35 | 664 | +629 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 148 | 682 | +534 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 341 | +341 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 308 | +308 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 24,618 | 24,828 | +210 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 154 | +154 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,247 | 15,398 | +151 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |