| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 1,000,000 | 3,063,292 | +2,063,292 | 0.27 | 0.69 | +0.41 | buy |
| Woodline Partners LP | 276,904 | 1,518,561 | +1,241,657 | 0.01 | 0.03 | +0.02 | buy |
| Casdin Capital, LLC | 8,948,574 | 9,098,574 | +150,000 | 2.45 | 1.95 | -0.51 | buy |
| ALGERT GLOBAL LLC | 994,923 | 931,251 | +63,672 | 0.10 | 0.06 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 330,699 | 382,900 | +52,201 | 0.11 | 0.08 | 0.00 | buy |
| Ikarian Capital, LLC | 693,308 | 743,308 | +50,000 | 0.82 | 0.63 | -0.18 | buy |
| EntryPoint Capital, LLC | 22,325 | 71,486 | +49,161 | 0.04 | 0.09 | +0.05 | buy |
| MPM BioImpact LLC | 2,268,825 | 2,295,924 | +27,099 | 1.33 | 1.03 | -0.29 | buy |
| NEOS Investment Management LLC | 64,655 | 89,110 | +24,455 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 64,655 | 89,110 | +24,455 | 0.11 | 0.07 | -0.04 | buy |
| E Fund Management Co., Ltd. | 17,654 | 19,165 | +1,511 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,515 | 4,286 | +771 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 584,463 | 584,530 | +67 | 0.00 | 0.00 | -0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 157,485 | 156,202 | -1,283 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 35,491 | 34,003 | -1,488 | 0.01 | 0.01 | -0.01 | sell |
| TrueMark Investments, LLC | 55,400 | 51,536 | -3,864 | 0.07 | 0.04 | -0.04 | sell |
| PROFUND ADVISORS LLC | 48,539 | 42,929 | -5,610 | 0.01 | 0.00 | -0.00 | sell |
| SHERBROOKE PARK ADVISERS LLC | 28,959 | 20,519 | -8,440 | 0.04 | 0.03 | -0.01 | sell |
| Rafferty Asset Management, LLC | 249,561 | 205,068 | -44,493 | 0.00 | 0.00 | -0.00 | sell |
| Persistent Asset Partners Ltd | 145,828 | 100,484 | -45,344 | 0.56 | 0.23 | -0.33 | sell |
| PDT Partners, LLC | 108,599 | 53,637 | -54,962 | 0.04 | 0.01 | -0.03 | sell |
| Finepoint Capital LP | 2,175,646 | 2,117,646 | -58,000 | 0.55 | 0.42 | -0.12 | sell |
| DIADEMA PARTNERS LP | 505,778 | 426,346 | -79,432 | 2.35 | 0.89 | -1.46 | sell |
| Parkman Healthcare Partners LLC | 500,548 | 188,052 | -312,496 | 0.27 | 0.06 | -0.22 | sell |
| Candriam S.C.A. | 1,729,199 | 580,136 | -1,149,063 | 0.04 | 0.01 | -0.03 | sell |