| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,903,245 | 9,751,141 | +7,847,896 | 0.29 | 1.92 | +1.62 | buy |
| FMR LLC | 162,222 | 3,695,431 | +3,533,209 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 2,590,000 | +2,090,000 | 0.01 | 0.04 | +0.03 | buy |
| EcoR1 Capital, LLC | 0 | 1,904,762 | +1,904,762 | 0.00 | 0.81 | +0.81 | buy |
| Casdin Capital, LLC | 13,003,574 | 14,418,574 | +1,415,000 | 6.83 | 10.86 | +4.03 | buy |
| TCG Crossover Management, LLC | 3,220,186 | 4,273,356 | +1,053,170 | 0.90 | 1.22 | +0.31 | buy |
| MARSHALL WACE, LLP | 0 | 941,825 | +941,825 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,099,912 | 3,039,179 | +939,267 | 0.03 | 0.06 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 1,040,949 | 1,937,695 | +896,746 | 0.00 | 0.00 | +0.00 | buy |
| Nextech Invest, Ltd. | 4,701,506 | 5,526,506 | +825,000 | 3.85 | 3.87 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 818,041 | +818,041 | 0.00 | 0.03 | +0.03 | buy |
| Logos Global Management LP | 0 | 750,000 | +750,000 | 0.00 | 0.38 | +0.38 | buy |
| GOLDMAN SACHS GROUP INC | 1,859,634 | 2,541,861 | +682,227 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 668,289 | +668,289 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 619,652 | +619,652 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,138,688 | 1,675,387 | +536,699 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 470,544 | +470,544 | 0.00 | 0.23 | +0.23 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,480,350 | 2,940,536 | +460,186 | 0.00 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 389,563 | 837,038 | +447,475 | 0.01 | 0.02 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 408,436 | +408,436 | 0.00 | 0.70 | +0.70 | buy |
| Affinity Asset Advisors, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.23 | +0.23 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 356,924 | +356,924 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 76,476 | 423,536 | +347,060 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,645,403 | 1,924,938 | +279,535 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 278,302 | +278,302 | 0.00 | 1.63 | +1.63 | buy |
| UBS Group AG | 296,017 | 527,611 | +231,594 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 425,958 | 647,518 | +221,560 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 414,167 | 618,938 | +204,771 | 0.02 | 0.04 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,575 | 216,052 | +191,477 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 181,543 | +181,543 | 0.00 | 0.35 | +0.35 | buy |
| Tidal Investments LLC | 0 | 154,100 | +154,100 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,232,451 | 2,359,586 | +127,135 | 2.16 | 1.81 | -0.35 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,163,124 | 1,290,032 | +126,908 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,409,363 | 3,510,636 | +101,273 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 259,411 | 346,317 | +86,906 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 94,210 | 180,298 | +86,088 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,016 | 79,994 | +64,978 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 78,368 | 141,452 | +63,084 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 114,143 | 176,265 | +62,122 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 61,899 | +61,899 | 0.00 | 0.05 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 101,160 | 162,236 | +61,076 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 59,508 | +59,508 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 117,677 | 174,099 | +56,422 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 12,551 | 63,637 | +51,086 | 0.00 | 0.03 | +0.03 | buy |
| Aquatic Capital Management LLC | 0 | 48,120 | +48,120 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 0 | 47,626 | +47,626 | 0.00 | 0.05 | +0.05 | buy |
| IEQ CAPITAL, LLC | 162,285 | 205,310 | +43,025 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 111,555 | 154,100 | +42,545 | 0.07 | 0.10 | +0.03 | buy |
| State of New Jersey Common Pension Fund D | 0 | 41,464 | +41,464 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 40,463 | +40,463 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 36,096 | +36,096 | 0.00 | 0.00 | +0.00 | buy |
| Valeo Financial Advisors, LLC | 0 | 35,714 | +35,714 | 0.00 | 0.01 | +0.01 | buy |
| Gotham Asset Management, LLC | 0 | 33,606 | +33,606 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 177,486 | 209,707 | +32,221 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 181,988 | 214,170 | +32,182 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 157,406 | 188,940 | +31,534 | 0.03 | 0.03 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 36,873 | 65,573 | +28,700 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 87,037 | 112,843 | +25,806 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 647,899 | 673,599 | +25,700 | 0.01 | 0.01 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 22,521 | +22,521 | 0.00 | 0.09 | +0.09 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 22,075 | +22,075 | 0.00 | 0.06 | +0.06 | buy |
| Amundi | 0 | 21,381 | +21,381 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 21,350 | +21,350 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 21,123 | +21,123 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 20,004 | 39,467 | +19,463 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 17,516 | +17,516 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 16,358 | +16,358 | 0.00 | 0.06 | +0.06 | buy |
| DnB Asset Management AS | 0 | 15,814 | +15,814 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 85,836 | 101,349 | +15,513 | 0.00 | 0.00 | +0.00 | buy |
| MIRABELLA FINANCIAL SERVICES LLP | 0 | 15,121 | +15,121 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 13,869 | +13,869 | 0.00 | 0.00 | +0.00 | buy |
| GABELLI FUNDS LLC | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 10,738 | +10,738 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 25,630 | 36,130 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 12,900 | 23,200 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 0 | 10,048 | +10,048 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 681 | 10,719 | +10,038 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 61,853 | 71,880 | +10,027 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 57,234 | 66,739 | +9,505 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 47,644 | 55,384 | +7,740 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 432,493 | 440,185 | +7,692 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 65,447 | 72,739 | +7,292 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 123,994 | 129,612 | +5,618 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 27,141 | 32,577 | +5,436 | 0.01 | 0.01 | -0.00 | buy |
| Abel Hall, LLC | 12,984 | 18,237 | +5,253 | 0.03 | 0.04 | +0.01 | buy |
| Pictet Asset Management Holding SA | 15,052 | 19,592 | +4,540 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 12,462 | 16,840 | +4,378 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 378,703 | 382,920 | +4,217 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 27,587 | 31,582 | +3,995 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 17,277 | 21,188 | +3,911 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 12,838 | 16,421 | +3,583 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 28,243 | 31,716 | +3,473 | 0.02 | 0.02 | +0.01 | buy |
| Pallas Capital Advisors LLC | 25,120 | 28,573 | +3,453 | 0.01 | 0.01 | +0.00 | buy |
| KBC Group NV | 0 | 3,448 | +3,448 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 142,321 | 145,490 | +3,169 | 0.01 | 0.01 | -0.00 | buy |
| Cerity Partners LLC | 21,046 | 24,195 | +3,149 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 24,700 | 27,200 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 67,603 | 69,959 | +2,356 | 0.00 | 0.00 | +0.00 | buy |
| Plante Moran Financial Advisors, LLC | 8,764 | 10,836 | +2,072 | 0.00 | 0.01 | +0.00 | buy |