| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 2.36 | 3.59 | +1.23 | hold |
| Commodore Capital LP | 17,000,000 | 17,000,000 | 0 | 9.57 | 9.79 | +0.21 | hold |
| Casdin Capital, LLC | 13,003,574 | 14,418,574 | +1,415,000 | 6.83 | 10.86 | +4.03 | buy |
| BlackRock, Inc. | 13,228,502 | 12,975,299 | -253,203 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,903,245 | 9,751,141 | +7,847,896 | 0.29 | 1.92 | +1.62 | buy |
| Bellevue Group AG | 8,345,364 | 7,795,242 | -550,122 | 1.34 | 1.85 | +0.51 | sell |
| STATE STREET CORP | 6,426,111 | 6,233,545 | -192,566 | 0.00 | 0.00 | +0.00 | sell |
| Nextech Invest, Ltd. | 4,701,506 | 5,526,506 | +825,000 | 3.85 | 3.87 | +0.02 | buy |
| TCG Crossover Management, LLC | 3,220,186 | 4,273,356 | +1,053,170 | 0.90 | 1.22 | +0.31 | buy |
| FMR LLC | 162,222 | 3,695,431 | +3,533,209 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,409,363 | 3,510,636 | +101,273 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,099,912 | 3,039,179 | +939,267 | 0.03 | 0.06 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,480,350 | 2,940,536 | +460,186 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 2,590,000 | +2,090,000 | 0.01 | 0.04 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,859,634 | 2,541,861 | +682,227 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,232,451 | 2,359,586 | +127,135 | 2.16 | 1.81 | -0.35 | buy |
| BANK OF AMERICA CORP /DE/ | 1,040,949 | 1,937,695 | +896,746 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,645,403 | 1,924,938 | +279,535 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 1,904,762 | +1,904,762 | 0.00 | 0.81 | +0.81 | buy |
| NORTHERN TRUST CORP | 1,138,688 | 1,675,387 | +536,699 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 1,568,753 | 1,564,173 | -4,580 | 0.51 | 0.39 | -0.13 | sell |
| MORGAN STANLEY | 2,018,464 | 1,432,003 | -586,461 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 1,424,259 | 1,424,259 | 0 | 0.78 | 0.90 | +0.12 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,560,265 | 1,369,149 | -191,116 | 0.02 | 0.01 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,163,124 | 1,290,032 | +126,908 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.06 | 0.07 | +0.01 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,136,702 | 1,111,891 | -24,811 | 0.00 | 0.00 | +0.00 | sell |
| Foresite Capital Management IV, LLC | 1,000,000 | 1,000,000 | 0 | 3.68 | 4.20 | +0.51 | hold |
| MARSHALL WACE, LLP | 0 | 941,825 | +941,825 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 389,563 | 837,038 | +447,475 | 0.01 | 0.02 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 818,041 | +818,041 | 0.00 | 0.03 | +0.03 | buy |
| Logos Global Management LP | 0 | 750,000 | +750,000 | 0.00 | 0.38 | +0.38 | buy |
| Woodline Partners LP | 679,115 | 679,342 | +227 | 0.02 | 0.03 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 647,899 | 673,599 | +25,700 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 865,481 | 669,874 | -195,607 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 668,289 | +668,289 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 425,958 | 647,518 | +221,560 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 619,652 | +619,652 | 0.00 | 0.01 | +0.01 | buy |
| CONGRESS ASSET MANAGEMENT CO | 414,167 | 618,938 | +204,771 | 0.02 | 0.04 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 541,124 | 541,124 | 0 | 0.10 | 0.14 | +0.04 | hold |
| UBS Group AG | 296,017 | 527,611 | +231,594 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 470,544 | +470,544 | 0.00 | 0.23 | +0.23 | buy |
| BESSEMER GROUP INC | 457,869 | 457,869 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 432,493 | 440,185 | +7,692 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 76,476 | 423,536 | +347,060 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 545,079 | 421,881 | -123,198 | 1.19 | 1.16 | -0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 408,436 | +408,436 | 0.00 | 0.70 | +0.70 | buy |
| Affinity Asset Advisors, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.23 | +0.23 | buy |
| Bank of New York Mellon Corp | 378,703 | 382,920 | +4,217 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 460,000 | 360,000 | -100,000 | 0.36 | 0.44 | +0.08 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 356,924 | +356,924 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 896,909 | 347,733 | -549,176 | 0.01 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 259,411 | 346,317 | +86,906 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 339,080 | 339,080 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Hudson Bay Capital Management LP | 451,500 | 311,330 | -140,170 | 0.02 | 0.02 | -0.00 | sell |
| Nuveen, LLC | 300,464 | 302,196 | +1,732 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 456,648 | 290,352 | -166,296 | 0.01 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 278,302 | +278,302 | 0.00 | 1.63 | +1.63 | buy |
| Eversept Partners, LP | 489,137 | 270,705 | -218,432 | 0.23 | 0.18 | -0.05 | sell |
| Swiss National Bank | 238,000 | 238,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 215,741 | 216,933 | +1,192 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 24,575 | 216,052 | +191,477 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 181,988 | 214,170 | +32,182 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 209,848 | 210,468 | +620 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 177,486 | 209,707 | +32,221 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 162,285 | 205,310 | +43,025 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 220,949 | 197,535 | -23,414 | 0.00 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 250,000 | 190,000 | -60,000 | 0.03 | 0.03 | -0.00 | sell |
| XTX Topco Ltd | 157,406 | 188,940 | +31,534 | 0.03 | 0.03 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 186,388 | 186,123 | -265 | 0.00 | 0.00 | +0.00 | sell |
| TFG Asset Management GP Ltd | 0 | 181,543 | +181,543 | 0.00 | 0.35 | +0.35 | buy |
| Squarepoint Ops LLC | 94,210 | 180,298 | +86,088 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 114,143 | 176,265 | +62,122 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 117,677 | 174,099 | +56,422 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 101,160 | 162,236 | +61,076 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 154,100 | +154,100 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 111,555 | 154,100 | +42,545 | 0.07 | 0.10 | +0.03 | buy |
| Rafferty Asset Management, LLC | 193,756 | 150,618 | -43,138 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 222,929 | 147,158 | -75,771 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 142,321 | 145,490 | +3,169 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 145,251 | 145,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Engineers Gate Manager LP | 78,368 | 141,452 | +63,084 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 123,994 | 129,612 | +5,618 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 87,037 | 112,843 | +25,806 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 157,892 | 109,952 | -47,940 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 85,836 | 101,349 | +15,513 | 0.00 | 0.00 | +0.00 | buy |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Trexquant Investment LP | 472,045 | 94,248 | -377,797 | 0.04 | 0.01 | -0.03 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 104,953 | 94,169 | -10,784 | 0.05 | 0.07 | +0.02 | sell |
| Legal & General Group Plc | 109,208 | 82,056 | -27,152 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 15,016 | 79,994 | +64,978 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 77,536 | 79,024 | +1,488 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,679 | 76,661 | -18 | 0.00 | 0.00 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 65,447 | 72,739 | +7,292 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 61,853 | 71,880 | +10,027 | 0.00 | 0.01 | +0.00 | buy |
| CWM, LLC | 67,603 | 69,959 | +2,356 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 72,586 | 68,170 | -4,416 | 0.02 | 0.02 | +0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 57,234 | 66,739 | +9,505 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 36,873 | 65,573 | +28,700 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 12,551 | 63,637 | +51,086 | 0.00 | 0.03 | +0.03 | buy |