| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.98 | +0.98 | buy |
| Casdin Capital, LLC | 7,423,574 | 8,448,574 | +1,025,000 | 4.59 | 4.21 | -0.38 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 206,756 | 1,191,183 | +984,427 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 237,200 | 1,163,336 | +926,136 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 227,906 | 1,149,177 | +921,271 | 0.00 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 5,926,618 | 6,377,115 | +450,497 | 0.75 | 0.68 | -0.07 | buy |
| MPM BioImpact LLC | 832,017 | 1,274,459 | +442,442 | 1.11 | 1.29 | +0.18 | buy |
| MARSHALL WACE, LLP | 0 | 276,702 | +276,702 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,717,268 | 3,963,401 | +246,133 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 397,918 | 616,220 | +218,302 | 0.03 | 0.04 | +0.01 | buy |
| Candriam S.C.A. | 508,429 | 703,429 | +195,000 | 0.03 | 0.03 | +0.00 | buy |
| Trexquant Investment LP | 0 | 184,621 | +184,621 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 301,935 | 476,888 | +174,953 | 0.10 | 0.10 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,216,793 | 2,364,797 | +148,004 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 763,200 | 909,037 | +145,837 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 144,986 | +144,986 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 587,690 | 730,022 | +142,332 | 0.01 | 0.01 | -0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 120,011 | +120,011 | 0.00 | 0.00 | +0.00 | buy |
| Finepoint Capital LP | 1,490,170 | 1,605,346 | +115,176 | 3.17 | 2.97 | -0.20 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 105,518 | +105,518 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13,939 | 106,169 | +92,230 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 362,450 | 450,345 | +87,895 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,157,021 | 1,242,278 | +85,257 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 152,991 | 226,632 | +73,641 | 0.12 | 0.14 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 27,421 | 98,404 | +70,983 | 0.02 | 0.04 | +0.03 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 61,424 | +61,424 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 141,439 | 198,402 | +56,963 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 247,291 | 303,345 | +56,054 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 741,703 | 795,482 | +53,779 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 14,550 | 67,243 | +52,693 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 306,448 | 354,667 | +48,219 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 46,702 | +46,702 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,353 | 99,796 | +41,443 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 15,325 | 53,442 | +38,117 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 0 | 36,382 | +36,382 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 14,222 | 48,381 | +34,159 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 22,780 | 54,605 | +31,825 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 394,300 | 424,800 | +30,500 | 0.01 | 0.01 | -0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 14,506 | 44,511 | +30,005 | 0.00 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 9,569 | 38,656 | +29,087 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 149,194 | 178,088 | +28,894 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 26,926 | +26,926 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 725,000 | 750,000 | +25,000 | 0.59 | 0.49 | -0.10 | buy |
| ALLIANCEBERNSTEIN L.P. | 538,603 | 562,855 | +24,252 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 231 | 23,267 | +23,036 | 0.00 | 0.07 | +0.07 | buy |
| Entropy Technologies, LP | 0 | 22,809 | +22,809 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 18,939 | 41,339 | +22,400 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 411 | 22,240 | +21,829 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 57,826 | 76,971 | +19,145 | 0.01 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 137,434 | 156,254 | +18,820 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 53,414 | 71,913 | +18,499 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 14,432 | +14,432 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 46,053 | 57,689 | +11,636 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 44,600 | 55,450 | +10,850 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,531 | 43,805 | +10,274 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 26,391 | 35,800 | +9,409 | 0.05 | 0.04 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 68,859 | 76,539 | +7,680 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 156,387 | 163,895 | +7,508 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 25,108 | 31,726 | +6,618 | 0.02 | 0.01 | -0.01 | buy |
| EverSource Wealth Advisors, LLC | 0 | 5,750 | +5,750 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 38,600 | 43,900 | +5,300 | 0.03 | 0.03 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 29,887 | 35,063 | +5,176 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 163,500 | 167,800 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 30,051 | 33,334 | +3,283 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 8,702 | 11,569 | +2,867 | 0.04 | 0.04 | -0.00 | buy |
| Corton Capital Inc. | 18,109 | 20,630 | +2,521 | 0.06 | 0.07 | +0.02 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 150 | 2,409 | +2,259 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 905 | 2,783 | +1,878 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 22,769 | 23,870 | +1,101 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 1,096 | +1,096 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 1,038 | +1,038 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 23 | 846 | +823 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 87,087 | 87,806 | +719 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 65,441 | 66,150 | +709 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 36,331 | 36,960 | +629 | 0.04 | 0.02 | -0.02 | buy |
| SIGNATUREFD, LLC | 0 | 624 | +624 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 273,008 | 273,616 | +608 | 0.02 | 0.02 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 25,217 | 25,807 | +590 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 84,013 | 84,431 | +418 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 306 | +306 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 18,436 | 18,722 | +286 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 3,072 | 3,355 | +283 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 100 | 348 | +248 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 78 | 309 | +231 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,678 | 1,905 | +227 | 0.00 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 60 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Mesirow Financial Investment Management, Inc. | 17,627 | 17,667 | +40 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,678 | 36,699 | +21 | 0.00 | 0.00 | -0.00 | buy |
| TFC Financial Management, Inc. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BOSTON FAMILY OFFICE LLC | 12,397 | 12,397 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CANADA LIFE ASSURANCE Co | 8,624 | 8,624 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BESSEMER GROUP INC | 584,463 | 584,463 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ADIRONDACK TRUST CO | 344 | 344 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 8,970 | 8,970 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 153,769 | 153,769 | 0 | 0.00 | 0.00 | -0.00 | hold |
| C M BIDWELL & ASSOCIATES LTD | 396 | 396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRANDYWINE MANAGERS, LLC | 31,807 | 31,807 | 0 | 0.26 | 0.22 | -0.04 | hold |
| HARBOURVEST PARTNERS LLC | 296,402 | 296,402 | 0 | 1.12 | 1.03 | -0.09 | hold |