| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 2.29 | 1.68 | -0.60 | hold |
| VANGUARD GROUP INC | 11,815,669 | 11,704,866 | -110,803 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 7,423,574 | 8,448,574 | +1,025,000 | 4.59 | 4.21 | -0.38 | buy |
| Bellevue Group AG | 5,926,618 | 6,377,115 | +450,497 | 0.75 | 0.68 | -0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,879,597 | 5,039,015 | -1,840,582 | 0.01 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 6,020,988 | 4,248,406 | -1,772,582 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 3,717,268 | 3,963,401 | +246,133 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 3,392,625 | 3,319,342 | -73,283 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 3,743,999 | 3,006,799 | -737,200 | 1.00 | 0.61 | -0.39 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,216,793 | 2,364,797 | +148,004 | 0.00 | 0.00 | -0.00 | buy |
| Finepoint Capital LP | 1,490,170 | 1,605,346 | +115,176 | 3.17 | 2.97 | -0.20 | buy |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.52 | 0.52 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,600,814 | 1,520,340 | -80,474 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,763,148 | 1,484,518 | -278,630 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.98 | +0.98 | buy |
| MPM BioImpact LLC | 832,017 | 1,274,459 | +442,442 | 1.11 | 1.29 | +0.18 | buy |
| MORGAN STANLEY | 1,157,021 | 1,242,278 | +85,257 | 0.00 | 0.00 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 206,756 | 1,191,183 | +984,427 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 237,200 | 1,163,336 | +926,136 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.12 | 0.10 | -0.02 | hold |
| MILLENNIUM MANAGEMENT LLC | 227,906 | 1,149,177 | +921,271 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 763,200 | 909,037 | +145,837 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 912,157 | 821,391 | -90,766 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 828,407 | 814,412 | -13,995 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 741,703 | 795,482 | +53,779 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 725,000 | 750,000 | +25,000 | 0.59 | 0.49 | -0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 587,690 | 730,022 | +142,332 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 508,429 | 703,429 | +195,000 | 0.03 | 0.03 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 397,918 | 616,220 | +218,302 | 0.03 | 0.04 | +0.01 | buy |
| BESSEMER GROUP INC | 584,463 | 584,463 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 538,603 | 562,855 | +24,252 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 4,005,170 | 541,124 | -3,464,046 | 0.37 | 0.04 | -0.33 | sell |
| ALGERT GLOBAL LLC | 301,935 | 476,888 | +174,953 | 0.10 | 0.10 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 362,450 | 450,345 | +87,895 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 394,300 | 424,800 | +30,500 | 0.01 | 0.01 | -0.00 | buy |
| Prosight Management, LP | 450,000 | 385,000 | -65,000 | 1.04 | 0.75 | -0.29 | sell |
| Bank of New York Mellon Corp | 306,448 | 354,667 | +48,219 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 336,490 | 312,444 | -24,046 | 0.01 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 247,291 | 303,345 | +56,054 | 0.00 | 0.00 | -0.00 | buy |
| HARBOURVEST PARTNERS LLC | 296,402 | 296,402 | 0 | 1.12 | 1.03 | -0.09 | hold |
| BAILLIE GIFFORD & CO | 353,226 | 284,058 | -69,168 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 276,702 | +276,702 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 273,008 | 273,616 | +608 | 0.02 | 0.02 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 230,000 | 230,000 | 0 | 0.18 | 0.14 | -0.04 | hold |
| PDT Partners, LLC | 152,991 | 226,632 | +73,641 | 0.12 | 0.14 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 450,172 | 219,725 | -230,447 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 235,186 | 215,588 | -19,598 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 557,296 | 209,649 | -347,647 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 208,356 | 208,356 | 0 | 0.04 | 0.06 | +0.02 | hold |
| TD ASSET MANAGEMENT INC | 358,656 | 206,056 | -152,600 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 141,439 | 198,402 | +56,963 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 464,060 | 193,932 | -270,128 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 287,926 | 189,320 | -98,606 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 184,621 | +184,621 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 149,194 | 178,088 | +28,894 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 163,500 | 167,800 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 156,387 | 163,895 | +7,508 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 137,434 | 156,254 | +18,820 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 153,769 | 153,769 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONGRESS ASSET MANAGEMENT CO | 149,082 | 147,610 | -1,472 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 144,986 | +144,986 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 120,011 | +120,011 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 139,996 | 115,278 | -24,718 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 116,883 | 114,513 | -2,370 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13,939 | 106,169 | +92,230 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 105,518 | +105,518 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 187,982 | 101,365 | -86,617 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,353 | 99,796 | +41,443 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 27,421 | 98,404 | +70,983 | 0.02 | 0.04 | +0.03 | buy |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 87,087 | 87,806 | +719 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 84,013 | 84,431 | +418 | 0.00 | 0.00 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 57,826 | 76,971 | +19,145 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 68,859 | 76,539 | +7,680 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 53,414 | 71,913 | +18,499 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,086,089 | 70,476 | -1,015,613 | 0.00 | 0.00 | -0.00 | sell |
| Intellectus Partners, LLC | 69,260 | 67,675 | -1,585 | 0.15 | 0.12 | -0.03 | sell |
| AQR CAPITAL MANAGEMENT LLC | 14,550 | 67,243 | +52,693 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 65,441 | 66,150 | +709 | 0.01 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 999,639 | 65,989 | -933,650 | 0.02 | 0.00 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 61,424 | +61,424 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 68,937 | 60,000 | -8,937 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 46,053 | 57,689 | +11,636 | 0.00 | 0.00 | -0.00 | buy |
| Ensign Peak Advisors, Inc | 44,600 | 55,450 | +10,850 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 22,780 | 54,605 | +31,825 | 0.01 | 0.01 | +0.00 | buy |
| TrueMark Investments, LLC | 54,445 | 54,445 | 0 | 0.41 | 0.12 | -0.29 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,720 | 54,391 | -9,329 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 15,325 | 53,442 | +38,117 | 0.01 | 0.01 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 14,222 | 48,381 | +34,159 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 49,374 | 48,300 | -1,074 | 0.01 | 0.01 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 46,702 | +46,702 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 14,506 | 44,511 | +30,005 | 0.00 | 0.01 | +0.00 | buy |
| Bayesian Capital Management, LP | 38,600 | 43,900 | +5,300 | 0.03 | 0.03 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,531 | 43,805 | +10,274 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 414,977 | 43,590 | -371,387 | 0.00 | 0.00 | -0.00 | sell |
| Pennant Investors, LP | 42,400 | 42,400 | 0 | 0.10 | 0.08 | -0.02 | hold |
| HSBC HOLDINGS PLC | 18,939 | 41,339 | +22,400 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 9,569 | 38,656 | +29,087 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 51,615 | 37,970 | -13,645 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 36,331 | 36,960 | +629 | 0.04 | 0.02 | -0.02 | buy |