| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 7,423,574 | 8,448,574 | +1,025,000 | 4.59 | 4.21 | -0.38 | buy |
| Bellevue Group AG | 5,926,618 | 6,377,115 | +450,497 | 0.75 | 0.68 | -0.07 | buy |
| MPM BioImpact LLC | 832,017 | 1,274,459 | +442,442 | 1.11 | 1.29 | +0.18 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 397,918 | 616,220 | +218,302 | 0.03 | 0.04 | +0.01 | buy |
| Candriam S.C.A. | 508,429 | 703,429 | +195,000 | 0.03 | 0.03 | +0.00 | buy |
| ALGERT GLOBAL LLC | 301,935 | 476,888 | +174,953 | 0.10 | 0.11 | 0.00 | buy |
| Finepoint Capital LP | 1,490,170 | 1,605,346 | +115,176 | 3.17 | 2.97 | -0.20 | buy |
| PDT Partners, LLC | 152,991 | 226,632 | +73,641 | 0.12 | 0.14 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 15,325 | 53,442 | +38,117 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 72,349 | 36,418 | +35,931 | 0.02 | 0.01 | 0.00 | sell |
| ROYCE & ASSOCIATES LP | 14,222 | 48,381 | +34,159 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 22,780 | 54,605 | +31,825 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 725,000 | 750,000 | +25,000 | 0.59 | 0.49 | -0.10 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 57,826 | 76,971 | +19,145 | 0.01 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 26,391 | 35,800 | +9,409 | 0.05 | 0.04 | -0.00 | buy |
| Bayesian Capital Management, LP | 38,600 | 43,900 | +5,300 | 0.03 | 0.03 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 8,702 | 11,569 | +2,867 | 0.04 | 0.04 | -0.00 | buy |
| Corton Capital Inc. | 18,109 | 20,630 | +2,521 | 0.06 | 0.07 | +0.02 | buy |
| Woodline Partners LP | 273,008 | 273,616 | +608 | 0.02 | 0.02 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 23,088 | 22,854 | -234 | 0.03 | 0.02 | -0.01 | sell |
| CONGRESS ASSET MANAGEMENT CO | 149,082 | 147,610 | -1,472 | 0.01 | 0.01 | -0.00 | sell |
| Intellectus Partners, LLC | 69,260 | 67,675 | -1,585 | 0.15 | 0.12 | -0.03 | sell |
| China Universal Asset Management Co., Ltd. | 25,210 | 15,594 | -9,616 | 0.03 | 0.01 | -0.01 | sell |
| E Fund Management Co., Ltd. | 21,930 | 11,778 | -10,152 | 0.01 | 0.00 | -0.01 | sell |
| SHERBROOKE PARK ADVISERS LLC | 44,692 | 14,965 | -29,727 | 0.07 | 0.02 | -0.06 | sell |
| Prosight Management, LP | 450,000 | 385,000 | -65,000 | 1.04 | 0.75 | -0.29 | sell |
| BAILLIE GIFFORD & CO | 353,226 | 284,058 | -69,168 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 464,060 | 193,932 | -270,128 | 0.01 | 0.00 | -0.01 | sell |
| BRAIDWELL LP | 3,743,999 | 3,006,799 | -737,200 | 1.00 | 0.61 | -0.39 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,879,597 | 5,039,015 | -1,840,582 | 0.01 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 4,005,170 | 541,124 | -3,464,046 | 0.37 | 0.04 | -0.33 | sell |