| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 0.67 | 0.77 | +0.10 | hold |
| BlackRock, Inc. | 14,478,798 | 13,954,486 | -524,312 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 10,827,067 | 13,445,704 | +2,618,637 | 0.08 | 0.11 | +0.03 | buy |
| Commodore Capital LP | 0 | 13,350,000 | +13,350,000 | 0.00 | 3.26 | +3.26 | buy |
| Casdin Capital, LLC | 9,098,574 | 11,398,574 | +2,300,000 | 1.95 | 3.59 | +1.64 | buy |
| VANGUARD GROUP INC | 12,105,420 | 9,379,851 | -2,725,569 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 7,377,292 | 8,230,870 | +853,578 | 0.43 | 0.63 | +0.19 | buy |
| TANG CAPITAL MANAGEMENT LLC | 8,068,058 | 8,068,058 | 0 | 1.17 | 1.41 | +0.24 | hold |
| STATE STREET CORP | 5,159,192 | 5,202,791 | +43,599 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 4,909,771 | 4,338,403 | -571,368 | 0.00 | 0.00 | +0.00 | sell |
| Nextech Invest, Ltd. | 3,846,409 | 3,846,409 | 0 | 2.34 | 2.52 | +0.18 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,070,118 | 3,229,666 | +159,548 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,063,292 | 2,887,014 | -176,278 | 0.69 | 1.08 | +0.39 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,477,791 | 2,875,936 | -601,855 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,799,091 | 2,789,460 | -9,631 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 2,295,924 | 2,282,680 | -13,244 | 1.03 | 1.37 | +0.33 | sell |
| GOLDMAN SACHS GROUP INC | 2,077,995 | 1,935,167 | -142,828 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,942,875 | 1,870,362 | -1,072,513 | 0.01 | 0.01 | -0.00 | sell |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.26 | 0.25 | -0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 2,276,110 | 1,508,210 | -767,900 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 1,593,186 | 1,422,346 | -170,840 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 554,428 | 1,320,130 | +765,702 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,142,928 | 1,162,092 | +19,164 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.03 | 0.04 | +0.01 | hold |
| TWO SIGMA ADVISERS, LP | 751,200 | 1,139,800 | +388,600 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,064,858 | 1,106,260 | +41,402 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 364,946 | 1,083,465 | +718,519 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 843,856 | 1,023,384 | +179,528 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 1,518,561 | 1,018,115 | -500,446 | 0.03 | 0.02 | -0.01 | sell |
| ALGERT GLOBAL LLC | 931,251 | 1,002,016 | +70,765 | 0.06 | 0.07 | +0.01 | buy |
| Foresite Capital Management IV, LLC | 1,000,000 | 1,000,000 | 0 | 2.36 | 2.79 | +0.44 | hold |
| NORGES BANK | 4,635,137 | 835,874 | -3,799,263 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 682,028 | 794,619 | +112,591 | 0.01 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 743,308 | 743,308 | 0 | 0.63 | 0.85 | +0.22 | hold |
| TFG Asset Management GP Ltd | 619,000 | 699,000 | +80,000 | 0.52 | 0.44 | -0.08 | buy |
| BESSEMER GROUP INC | 584,530 | 584,530 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 469,171 | 556,522 | +87,351 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 541,124 | 541,124 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Eversept Partners, LP | 0 | 533,409 | +533,409 | 0.00 | 0.19 | +0.19 | buy |
| Rhenman & Partners Asset Management AB | 460,000 | 460,000 | 0 | 0.14 | 0.20 | +0.06 | hold |
| Private Capital Advisors, Inc. | 100,000 | 441,739 | +341,739 | 0.03 | 0.19 | +0.15 | buy |
| ROYAL BANK OF CANADA | 0 | 438,032 | +438,032 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 372,353 | 410,896 | +38,543 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 301,550 | 408,902 | +107,352 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 171,080 | 394,122 | +223,042 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 329,905 | 358,371 | +28,466 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 393,375 | 358,225 | -35,150 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 308,752 | 349,420 | +40,668 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 256,783 | 306,069 | +49,286 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 205,721 | 298,510 | +92,789 | 0.00 | 0.00 | +0.00 | buy |
| HARBOURVEST PARTNERS LLC | 296,402 | 296,402 | 0 | 0.51 | 1.12 | +0.62 | hold |
| Verition Fund Management LLC | 139,244 | 290,599 | +151,355 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 320,395 | 288,450 | -31,945 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 356,165 | 279,212 | -76,953 | 0.02 | 0.03 | +0.01 | sell |
| Invesco Ltd. | 184,831 | 273,383 | +88,552 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 79,913 | 241,230 | +161,317 | 0.01 | 0.03 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 238,814 | +238,814 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 227,000 | 227,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 226,737 | 222,987 | -3,750 | 0.02 | 0.02 | +0.00 | sell |
| RHUMBLINE ADVISERS | 174,125 | 221,853 | +47,728 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 205,579 | 212,126 | +6,547 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 184,533 | 190,488 | +5,955 | 0.00 | 0.00 | +0.00 | buy |
| CW Advisors, LLC | 186,063 | 186,063 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rafferty Asset Management, LLC | 205,068 | 181,957 | -23,111 | 0.00 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 180,000 | 180,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| IEQ CAPITAL, LLC | 56,334 | 179,324 | +122,990 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 275,558 | 173,090 | -102,468 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 170,196 | +170,196 | 0.00 | 0.01 | +0.01 | buy |
| Savant Capital, LLC | 78,814 | 168,447 | +89,633 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 166,668 | 166,668 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 43,015 | 158,179 | +115,164 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 156,202 | 156,700 | +498 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 149,701 | +149,701 | 0.00 | 0.19 | +0.19 | buy |
| ALLIANCEBERNSTEIN L.P. | 168,281 | 145,251 | -23,030 | 0.00 | 0.00 | +0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 382,900 | 127,036 | -255,864 | 0.02 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 260,313 | 123,393 | -136,920 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 129,215 | 112,316 | -16,899 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 70,769 | 109,787 | +39,018 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 106,287 | 106,287 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSBC HOLDINGS PLC | 116,408 | 104,257 | -12,151 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 6,055 | 101,057 | +95,002 | 0.00 | 0.05 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 156,456 | 99,056 | -57,400 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 89,110 | 97,150 | +8,040 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 89,110 | 97,150 | +8,040 | 0.07 | 0.09 | +0.02 | buy |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ALPS ADVISORS INC | 0 | 92,528 | +92,528 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 114,619 | 87,551 | -27,068 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 75,514 | 84,980 | +9,466 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 84,069 | 82,363 | -1,706 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 52,479 | 80,562 | +28,083 | 0.01 | 0.02 | +0.01 | buy |
| MetLife Investment Management, LLC | 65,272 | 75,117 | +9,845 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 23,117 | 72,618 | +49,501 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 96,313 | 71,217 | -25,096 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 65,340 | 68,615 | +3,275 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 61,425 | 61,425 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Allspring Global Investments Holdings, LLC | 63,606 | 60,331 | -3,275 | 0.00 | 0.00 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 68,937 | 60,000 | -8,937 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 20,269 | 56,993 | +36,724 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 31,778 | 55,174 | +23,396 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 81,428 | 54,243 | -27,185 | 0.00 | 0.00 | -0.00 | sell |