| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 3.59 | 6.81 | +3.22 | hold |
| FMR LLC | 3,695,431 | 20,110,113 | +16,414,682 | 0.00 | 0.02 | +0.01 | buy |
| Casdin Capital, LLC | 14,418,574 | 16,035,240 | +1,616,666 | 10.86 | 15.02 | +4.15 | buy |
| BlackRock, Inc. | 12,975,299 | 15,288,202 | +2,312,903 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 9,751,141 | 14,106,187 | +4,355,046 | 1.92 | 4.10 | +2.18 | buy |
| Commodore Capital LP | 17,000,000 | 12,000,000 | -5,000,000 | 9.79 | 13.37 | +3.59 | sell |
| STATE STREET CORP | 6,233,545 | 10,125,381 | +3,891,836 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,924,938 | 7,708,507 | +5,783,569 | 0.00 | 0.01 | +0.01 | buy |
| Nextech Invest, Ltd. | 5,526,506 | 6,776,506 | +1,250,000 | 3.87 | 6.02 | +2.15 | buy |
| Bellevue Group AG | 7,795,242 | 6,185,970 | -1,609,272 | 1.85 | 2.44 | +0.59 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,510,636 | 4,726,576 | +1,215,940 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 4,273,356 | 4,273,356 | 0 | 1.22 | 1.92 | +0.71 | hold |
| ALLIANCEBERNSTEIN L.P. | 145,251 | 4,095,600 | +3,950,349 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,432,003 | 3,851,071 | +2,419,068 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 3,650,000 | +3,650,000 | 0.00 | 1.39 | +1.39 | buy |
| GOLDMAN SACHS GROUP INC | 2,541,861 | 3,408,701 | +866,840 | 0.00 | 0.01 | +0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 3,343,496 | +3,343,496 | 0.00 | 0.20 | +0.20 | buy |
| Kynam Capital Management, LP | 1,424,259 | 3,300,000 | +1,875,741 | 0.90 | 3.41 | +2.51 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,940,536 | 3,127,564 | +187,028 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 2,826,783 | +1,666,666 | 0.07 | 0.27 | +0.20 | buy |
| BANK OF AMERICA CORP /DE/ | 1,937,695 | 2,695,108 | +757,413 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 2,359,586 | 2,415,672 | +56,086 | 1.81 | 2.76 | +0.94 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 668,289 | 2,238,929 | +1,570,640 | 0.00 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 19,592 | 2,077,297 | +2,057,705 | 0.00 | 0.04 | +0.04 | buy |
| NORTHERN TRUST CORP | 1,675,387 | 1,953,456 | +278,069 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,915,459 | +1,915,459 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 48,915 | 1,856,913 | +1,807,998 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 0 | 1,789,056 | +1,789,056 | 0.00 | 0.09 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,590,000 | 1,740,000 | -850,000 | 0.04 | 0.05 | +0.01 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 1,500,817 | +1,500,817 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,111,891 | 1,500,817 | +388,926 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 1,564,173 | 1,410,029 | -154,144 | 0.39 | 0.03 | -0.36 | sell |
| PANAGORA ASSET MANAGEMENT INC | 818,041 | 1,291,182 | +473,141 | 0.03 | 0.07 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,290,032 | 1,279,473 | -10,559 | 0.01 | 0.01 | +0.00 | sell |
| Foresite Capital Management IV, LLC | 1,000,000 | 1,250,000 | +250,000 | 4.20 | 8.06 | +3.86 | buy |
| UBS Group AG | 527,611 | 1,094,980 | +567,369 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 1,075,126 | +1,075,126 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 400,000 | 1,050,000 | +650,000 | 0.23 | 0.96 | +0.73 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 1,015,693 | +1,015,693 | 0.00 | 0.41 | +0.41 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 837,038 | 961,702 | +124,664 | 0.02 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 679,342 | 929,692 | +250,350 | 0.03 | 0.05 | +0.03 | buy |
| JPMORGAN CHASE & CO | 647,518 | 801,657 | +154,139 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 346,317 | 783,065 | +436,748 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 719,576 | +719,576 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,369,149 | 700,921 | -668,228 | 0.01 | 0.01 | -0.00 | sell |
| EcoR1 Capital, LLC | 1,904,762 | 697,948 | -1,206,814 | 0.81 | 0.65 | -0.16 | sell |
| Invesco Ltd. | 669,874 | 692,584 | +22,710 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 618,938 | 626,141 | +7,203 | 0.04 | 0.07 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 347,733 | 591,675 | +243,942 | 0.00 | 0.01 | +0.00 | buy |
| TFG Asset Management GP Ltd | 181,543 | 570,311 | +388,768 | 0.35 | 1.74 | +1.38 | buy |
| Rhenman & Partners Asset Management AB | 360,000 | 566,000 | +206,000 | 0.44 | 1.00 | +0.56 | buy |
| ArrowMark Colorado Holdings LLC | 541,124 | 541,124 | 0 | 0.14 | 0.42 | +0.28 | hold |
| HighVista Strategies LLC | 421,881 | 506,235 | +84,354 | 1.16 | 2.16 | +1.00 | buy |
| AMERIPRISE FINANCIAL INC | 356,924 | 480,076 | +123,152 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 176,265 | 473,682 | +297,417 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 382,920 | 462,756 | +79,836 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 457,869 | 457,869 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Boxer Capital Management, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.63 | +0.63 | buy |
| Eversept Partners, LP | 270,705 | 434,314 | +163,609 | 0.18 | 0.44 | +0.27 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 414,005 | +414,005 | 0.00 | 0.18 | +0.18 | buy |
| LORD, ABBETT & CO. LLC | 0 | 410,723 | +410,723 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 302,196 | 392,691 | +90,495 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 372,169 | +372,169 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 16,840 | 361,407 | +344,567 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 358,333 | +358,333 | 0.00 | 0.32 | +0.32 | buy |
| Logos Global Management LP | 750,000 | 350,000 | -400,000 | 0.38 | 0.28 | -0.10 | sell |
| Duquesne Family Office LLC | 0 | 349,000 | +349,000 | 0.00 | 0.15 | +0.15 | buy |
| TD ASSET MANAGEMENT INC | 214,170 | 347,946 | +133,776 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 210,468 | 278,327 | +67,859 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209,707 | 263,506 | +53,799 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 29,754 | 248,233 | +218,479 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 216,933 | 241,076 | +24,143 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 216,052 | 238,836 | +22,784 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 238,000 | 236,600 | -1,400 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 408,436 | 233,836 | -174,600 | 0.70 | 0.63 | -0.07 | sell |
| DIADEMA PARTNERS LP | 0 | 230,677 | +230,677 | 0.00 | 1.52 | +1.52 | buy |
| ALPS ADVISORS INC | 145,490 | 220,386 | +74,896 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 109,952 | 203,737 | +93,785 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 673,599 | 192,399 | -481,200 | 0.01 | 0.00 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 0 | 184,178 | +184,178 | 0.00 | 0.03 | +0.03 | buy |
| Tidal Investments LLC | 154,100 | 176,782 | +22,682 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 154,100 | 176,782 | +22,682 | 0.10 | 0.11 | +0.00 | buy |
| Rafferty Asset Management, LLC | 150,618 | 174,785 | +24,167 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 174,099 | 169,944 | -4,155 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 129,612 | 164,036 | +34,424 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 158,017 | +158,017 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 59,508 | 156,906 | +97,398 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 94,248 | 152,017 | +57,769 | 0.01 | 0.02 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 186,123 | 149,664 | -36,459 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 82,056 | 127,676 | +45,620 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 205,310 | 126,829 | -78,481 | 0.01 | 0.01 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 162,236 | 125,949 | -36,287 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 48,120 | 120,197 | +72,077 | 0.01 | 0.08 | +0.06 | buy |
| Creative Planning | 101,349 | 114,131 | +12,782 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,039,179 | 112,989 | -2,926,190 | 0.06 | 0.00 | -0.06 | sell |
| Caption Management, LLC | 0 | 103,006 | +103,006 | 0.00 | 0.07 | +0.07 | buy |
| Cinctive Capital Management LP | 0 | 102,569 | +102,569 | 0.00 | 0.08 | +0.08 | buy |
| Susquehanna Portfolio Strategies, LLC | 339,080 | 101,291 | -237,789 | 0.05 | 0.03 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 0 | 99,348 | +99,348 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,158 | 96,549 | -50,609 | 0.00 | 0.00 | -0.00 | sell |