| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 5,998,574 | 6,923,574 | +925,000 | 6.58 | 6.49 | -0.09 | buy |
| Bellevue Group AG | 4,170,800 | 4,885,000 | +714,200 | 0.75 | 0.66 | -0.09 | buy |
| ArrowMark Colorado Holdings LLC | 3,418,669 | 3,810,579 | +391,910 | 0.47 | 0.39 | -0.08 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,345,517 | 8,608,946 | +263,429 | 0.01 | 0.01 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 263,507 | 497,490 | +233,983 | 0.00 | 0.01 | +0.00 | buy |
| Finepoint Capital LP | 701,570 | 870,870 | +169,300 | 3.05 | 3.65 | +0.60 | buy |
| PDT Partners, LLC | 23,092 | 140,849 | +117,757 | 0.04 | 0.15 | +0.11 | buy |
| Integral Health Asset Management, LLC | 700,000 | 800,000 | +100,000 | 1.15 | 0.95 | -0.20 | buy |
| ALGERT GLOBAL LLC | 124,250 | 200,823 | +76,573 | 0.07 | 0.08 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 59,389 | 112,101 | +52,712 | 0.08 | 0.09 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 96,385 | 146,846 | +50,461 | 0.04 | 0.03 | 0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 72,800 | 98,000 | +25,200 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 220,482 | 205,420 | +15,062 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 32,675 | 39,402 | +6,727 | 0.19 | 0.17 | -0.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 12,200 | 14,500 | +2,300 | 0.00 | 0.00 | -0.00 | buy |
| Intellectus Partners, LLC | 48,560 | 50,560 | +2,000 | 0.18 | 0.13 | -0.05 | buy |
| China Universal Asset Management Co., Ltd. | 1,594 | 3,135 | +1,541 | 0.01 | 0.01 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 40,278 | 41,192 | +914 | 0.10 | 0.07 | -0.03 | buy |
| CONGRESS ASSET MANAGEMENT CO | 146,227 | 146,434 | +207 | 0.02 | 0.01 | -0.01 | buy |
| CI INVESTMENTS INC. | 5,926 | 5,754 | +172 | 0.00 | 0.00 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 9,092 | 8,272 | -820 | 0.07 | 0.04 | -0.03 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 9,500 | 7,900 | -1,600 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,354,368 | 1,352,133 | -2,235 | 3.43 | 3.04 | -0.39 | sell |
| E Fund Management Co., Ltd. | 33,708 | 19,403 | -14,305 | 0.03 | 0.01 | -0.02 | sell |
| BAILLIE GIFFORD & CO | 411,308 | 394,450 | -16,858 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 113,113 | 63,931 | -49,182 | 0.08 | 0.03 | -0.05 | sell |
| GILDER GAGNON HOWE & CO LLC | 186,102 | 132,210 | -53,892 | 0.03 | 0.02 | -0.02 | sell |
| Rafferty Asset Management, LLC | 627,013 | 377,745 | -249,268 | 0.04 | 0.02 | -0.03 | sell |
| BVF INC/IL | 3,120,521 | 2,365,805 | -754,716 | 1.09 | 0.54 | -0.56 | sell |