| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 1.68 | 1.63 | -0.05 | hold |
| VANGUARD GROUP INC | 11,704,866 | 14,463,614 | +2,758,748 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 8,448,574 | 9,251,108 | +802,534 | 4.21 | 4.37 | +0.16 | buy |
| Bellevue Group AG | 6,377,115 | 7,377,184 | +1,000,069 | 0.68 | 0.85 | +0.17 | buy |
| NORGES BANK | 3,319,342 | 5,917,515 | +2,598,173 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,963,401 | 5,517,516 | +1,554,115 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,039,015 | 5,280,291 | +241,276 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,248,406 | 4,300,216 | +51,810 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 3,568,058 | +3,568,058 | 0.00 | 1.80 | +1.80 | buy |
| BRAIDWELL LP | 3,006,799 | 3,499,427 | +492,628 | 0.61 | 0.70 | +0.09 | buy |
| CITADEL ADVISORS LLC | 1,163,336 | 2,909,371 | +1,746,035 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,364,797 | 2,732,270 | +367,473 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 2,682,083 | +2,682,083 | 0.00 | 0.33 | +0.33 | buy |
| EcoR1 Capital, LLC | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.61 | +0.61 | buy |
| MPM BioImpact LLC | 1,274,459 | 2,033,041 | +758,582 | 1.29 | 2.16 | +0.87 | buy |
| GOLDMAN SACHS GROUP INC | 1,484,518 | 1,975,465 | +490,947 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 26,926 | 1,819,983 | +1,793,057 | 0.00 | 0.14 | +0.13 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,520,340 | 1,748,663 | +228,323 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,650,000 | +1,650,000 | 0.00 | 0.02 | +0.02 | buy |
| Finepoint Capital LP | 1,605,346 | 1,626,146 | +20,800 | 2.97 | 1.40 | -1.57 | buy |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.52 | 0.60 | +0.08 | hold |
| First Light Asset Management, LLC | 0 | 1,542,406 | +1,542,406 | 0.00 | 0.91 | +0.91 | buy |
| MARSHALL WACE, LLP | 276,702 | 1,405,714 | +1,129,012 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 35,063 | 1,396,842 | +1,361,779 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,349,400 | +1,349,400 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 795,482 | 1,251,323 | +455,841 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,191,183 | 1,230,376 | +39,193 | 0.03 | 0.03 | +0.00 | buy |
| First Turn Management, LLC | 0 | 1,226,354 | +1,226,354 | 0.00 | 1.37 | +1.37 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Candriam S.C.A. | 703,429 | 1,092,705 | +389,276 | 0.03 | 0.04 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,149,177 | 1,059,607 | -89,570 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 821,391 | 1,035,789 | +214,398 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 730,022 | 1,015,567 | +285,545 | 0.01 | 0.02 | +0.00 | buy |
| Foresite Capital Management IV, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 4.63 | +4.63 | buy |
| MORGAN STANLEY | 1,242,278 | 962,111 | -280,167 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 0 | 945,839 | +945,839 | 0.00 | 3.00 | +3.00 | buy |
| NORTHERN TRUST CORP | 814,412 | 938,266 | +123,854 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 910,000 | +910,000 | 0.00 | 0.54 | +0.54 | buy |
| Ikarian Capital, LLC | 0 | 693,350 | +693,350 | 0.00 | 1.52 | +1.52 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 909,037 | 671,095 | -237,942 | 0.01 | 0.01 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 626,058 | +626,058 | 0.00 | 2.37 | +2.37 | buy |
| TWO SIGMA ADVISERS, LP | 424,800 | 614,200 | +189,400 | 0.01 | 0.01 | +0.00 | buy |
| BESSEMER GROUP INC | 584,463 | 584,633 | +170 | 0.01 | 0.01 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 541,124 | 541,124 | 0 | 0.04 | 0.05 | +0.01 | hold |
| ALGERT GLOBAL LLC | 476,888 | 513,277 | +36,389 | 0.10 | 0.10 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 230,000 | 460,000 | +230,000 | 0.14 | 0.26 | +0.12 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 419,242 | +419,242 | 0.00 | 0.67 | +0.67 | buy |
| Exome Asset Management LLC | 0 | 414,629 | +414,629 | 0.00 | 1.98 | +1.98 | buy |
| Trexquant Investment LP | 184,621 | 411,862 | +227,241 | 0.02 | 0.04 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 450,345 | 376,645 | -73,700 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 376,014 | +376,014 | 0.00 | 0.24 | +0.24 | buy |
| Cubist Systematic Strategies, LLC | 0 | 359,332 | +359,332 | 0.00 | 0.04 | +0.04 | buy |
| Maven Securities LTD | 0 | 337,426 | +337,426 | 0.00 | 0.27 | +0.27 | buy |
| Monashee Investment Management LLC | 0 | 320,000 | +320,000 | 0.00 | 0.25 | +0.25 | buy |
| HARBOURVEST PARTNERS LLC | 296,402 | 296,402 | 0 | 1.03 | 1.09 | +0.06 | hold |
| Bank of New York Mellon Corp | 354,667 | 278,707 | -75,960 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 273,616 | 276,904 | +3,288 | 0.02 | 0.02 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 219,725 | 276,452 | +56,727 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 115,278 | 251,819 | +136,541 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 209,649 | 223,289 | +13,640 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 178,088 | 220,667 | +42,579 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 167,800 | 219,600 | +51,800 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 215,588 | 215,547 | -41 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 208,708 | +208,708 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 189,320 | 191,724 | +2,404 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 206,056 | 186,656 | -19,400 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 198,402 | 185,329 | -13,073 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 193,932 | 180,030 | -13,902 | 0.00 | 0.00 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 120,011 | 160,458 | +40,447 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 163,895 | 157,912 | -5,983 | 0.00 | 0.00 | +0.00 | sell |
| HighTower Advisors, LLC | 303,345 | 154,920 | -148,425 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 147,610 | 146,424 | -1,186 | 0.01 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 562,855 | 138,281 | -424,574 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 43,805 | 130,467 | +86,662 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 208,356 | 130,000 | -78,356 | 0.06 | 0.06 | +0.01 | sell |
| PDT Partners, LLC | 226,632 | 127,272 | -99,360 | 0.14 | 0.08 | -0.06 | sell |
| Legal & General Group Plc | 87,806 | 123,297 | +35,491 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 114,513 | 114,156 | -357 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 112,048 | +112,048 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 109,912 | +109,912 | 0.00 | 0.06 | +0.06 | buy |
| Jump Financial, LLC | 0 | 101,975 | +101,975 | 0.00 | 0.01 | +0.01 | buy |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.01 | 0.01 | +0.00 | hold |
| FMR LLC | 70,476 | 89,772 | +19,296 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 43,590 | 87,386 | +43,796 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,699 | 84,453 | +47,754 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 84,431 | 82,527 | -1,904 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 66,150 | 80,683 | +14,533 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,796 | 78,060 | -21,736 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 76,971 | 77,671 | +700 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 13,819 | 76,139 | +62,320 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 76,539 | 73,886 | -2,653 | 0.00 | 0.00 | +0.00 | sell |
| Intellectus Partners, LLC | 67,675 | 67,675 | 0 | 0.12 | 0.12 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56,111 | 61,822 | +5,711 | 0.00 | 0.00 | +0.00 | buy |
| TrueMark Investments, LLC | 54,445 | 60,004 | +5,559 | 0.12 | 0.14 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEOS Investment Management LLC | 54,605 | 58,290 | +3,685 | 0.01 | 0.01 | -0.00 | buy |
| MetLife Investment Management, LLC | 57,689 | 57,689 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 55,450 | 55,450 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 0 | 55,084 | +55,084 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 53,514 | 53,186 | -328 | 0.00 | 0.00 | +0.00 | sell |