| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Casdin Capital, LLC | 7,423,574 | 9,251,108 | +1,827,534 | 4.58 | 4.37 | -0.21 | buy |
| Bellevue Group AG | 6,377,115 | 7,377,184 | +1,000,069 | 0.68 | 0.85 | +0.17 | buy |
| MPM BioImpact LLC | 1,274,459 | 2,033,041 | +758,582 | 1.29 | 2.16 | +0.87 | buy |
| BRAIDWELL LP | 3,006,799 | 3,499,427 | +492,628 | 0.61 | 0.70 | +0.09 | buy |
| Candriam S.C.A. | 703,429 | 1,092,705 | +389,276 | 0.03 | 0.04 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,039,015 | 5,280,291 | +241,276 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 230,000 | 460,000 | +230,000 | 0.14 | 0.26 | +0.12 | buy |
| ALGERT GLOBAL LLC | 476,888 | 513,277 | +36,389 | 0.11 | 0.10 | 0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 14,965 | 39,491 | +24,526 | 0.02 | 0.06 | +0.05 | buy |
| Finepoint Capital LP | 1,605,346 | 1,626,146 | +20,800 | 2.97 | 0.84 | -2.13 | buy |
| China Universal Asset Management Co., Ltd. | 15,594 | 25,751 | +10,157 | 0.01 | 0.02 | +0.01 | buy |
| Corton Capital Inc. | 20,630 | 29,763 | +9,133 | 0.07 | 0.10 | +0.03 | buy |
| BRANDYWINE MANAGERS, LLC | 31,807 | 38,429 | +6,622 | 0.22 | 0.29 | +0.07 | buy |
| TrueMark Investments, LLC | 54,445 | 60,004 | +5,559 | 0.12 | 0.14 | +0.01 | buy |
| NEOS Investment Management LLC | 54,605 | 58,290 | +3,685 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 273,616 | 276,904 | +3,288 | 0.02 | 0.02 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 76,971 | 77,671 | +700 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 36,418 | 36,133 | +285 | 0.01 | 0.01 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 11,569 | 11,781 | +212 | 0.04 | 0.04 | +0.00 | buy |
| BESSEMER GROUP INC | 584,463 | 584,633 | +170 | 0.01 | 0.01 | +0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 396 | 543 | +147 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 11,778 | 11,550 | -228 | 0.00 | 0.00 | -0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 147,610 | 146,424 | -1,186 | 0.01 | 0.01 | +0.00 | sell |
| Entropy Technologies, LP | 22,809 | 12,202 | -10,607 | 0.02 | 0.01 | -0.01 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 22,854 | 10,811 | -12,043 | 0.02 | 0.02 | -0.00 | sell |
| Rafferty Asset Management, LLC | 193,932 | 180,030 | -13,902 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 35,800 | 18,553 | -17,247 | 0.04 | 0.03 | -0.01 | sell |
| Susquehanna Portfolio Strategies, LLC | 208,356 | 130,000 | -78,356 | 0.06 | 0.06 | +0.01 | sell |
| PDT Partners, LLC | 226,632 | 127,272 | -99,360 | 0.14 | 0.08 | -0.06 | sell |