| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 0.77 | 1.10 | +0.33 | hold |
| Commodore Capital LP | 13,350,000 | 17,000,000 | +3,650,000 | 3.26 | 4.33 | +1.07 | buy |
| Point72 Asset Management, L.P. | 13,445,704 | 14,773,676 | +1,327,972 | 0.11 | 0.17 | +0.06 | buy |
| BlackRock, Inc. | 13,954,486 | 13,759,382 | -195,104 | 0.00 | 0.00 | +0.00 | sell |
| Casdin Capital, LLC | 11,398,574 | 11,341,381 | -57,193 | 3.59 | 4.94 | +1.34 | sell |
| VANGUARD GROUP INC | 9,379,851 | 9,395,744 | +15,893 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 8,230,870 | 8,345,610 | +114,740 | 0.63 | 0.91 | +0.28 | buy |
| TANG CAPITAL MANAGEMENT LLC | 8,068,058 | 8,068,058 | 0 | 1.41 | 1.62 | +0.21 | hold |
| STATE STREET CORP | 5,202,791 | 5,065,990 | -136,801 | 0.00 | 0.00 | +0.00 | sell |
| Nextech Invest, Ltd. | 3,846,409 | 3,846,409 | 0 | 2.52 | 3.06 | +0.54 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,229,666 | 3,054,586 | -175,080 | 0.00 | 0.00 | +0.00 | sell |
| Kynam Capital Management, LP | 2,887,014 | 2,887,014 | 0 | 1.08 | 1.12 | +0.05 | hold |
| DIMENSIONAL FUND ADVISORS LP | 2,789,460 | 2,482,950 | -306,510 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 2,282,680 | 2,282,680 | 0 | 1.37 | 1.95 | +0.58 | hold |
| GOLDMAN SACHS GROUP INC | 1,935,167 | 1,868,871 | -66,296 | 0.00 | 0.00 | +0.00 | sell |
| TCG Crossover Management, LLC | 0 | 1,810,351 | +1,810,351 | 0.00 | 0.46 | +0.46 | buy |
| MORGAN STANLEY | 1,422,346 | 1,764,096 | +341,750 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.25 | 0.34 | +0.09 | hold |
| AQR CAPITAL MANAGEMENT LLC | 1,083,465 | 1,301,036 | +217,571 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,320,130 | 1,195,843 | -124,287 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,174,971 | +1,174,971 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,162,092 | 1,165,434 | +3,342 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.04 | 0.04 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,875,936 | 1,137,681 | -1,738,255 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,139,800 | 1,124,300 | -15,500 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,106,260 | 1,111,331 | +5,071 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,023,384 | 1,095,635 | +72,251 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,508,210 | 1,023,110 | -485,100 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 1,018,115 | 1,018,115 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Foresite Capital Management IV, LLC | 1,000,000 | 1,000,000 | 0 | 2.79 | 2.86 | +0.06 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,870,362 | 744,044 | -1,126,318 | 0.01 | 0.00 | -0.00 | sell |
| BESSEMER GROUP INC | 584,530 | 584,463 | -67 | 0.00 | 0.00 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 541,124 | 541,124 | 0 | 0.03 | 0.05 | +0.02 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 794,619 | 501,238 | -293,381 | 0.01 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 533,409 | 479,056 | -54,353 | 0.19 | 0.19 | +0.01 | sell |
| Ikarian Capital, LLC | 743,308 | 467,362 | -275,946 | 0.85 | 0.49 | -0.36 | sell |
| JPMORGAN CHASE & CO | 4,338,403 | 462,379 | -3,876,024 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 556,522 | 461,879 | -94,643 | 0.00 | 0.00 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 460,000 | 460,000 | 0 | 0.20 | 0.27 | +0.06 | hold |
| CONGRESS ASSET MANAGEMENT CO | 156,700 | 408,842 | +252,142 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 1,002,016 | 408,840 | -593,176 | 0.07 | 0.04 | -0.04 | sell |
| AMERICAN CENTURY COMPANIES INC | 349,420 | 393,704 | +44,284 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 394,122 | 379,363 | -14,759 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 358,371 | 371,578 | +13,207 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 273,383 | 361,190 | +87,807 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 238,814 | 339,080 | +100,266 | 0.02 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 288,450 | 288,450 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 149,701 | 240,459 | +90,758 | 0.19 | 0.31 | +0.12 | buy |
| Swiss National Bank | 227,000 | 232,700 | +5,700 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 699,000 | 223,123 | -475,877 | 0.44 | 0.17 | -0.27 | sell |
| ROYAL BANK OF CANADA | 438,032 | 220,553 | -217,479 | 0.00 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 180,000 | 220,000 | +40,000 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 221,853 | 217,592 | -4,261 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 190,488 | 214,823 | +24,335 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 408,902 | 202,244 | -206,658 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 14,117 | 197,706 | +183,589 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 179,324 | 196,459 | +17,135 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 298,510 | 187,821 | -110,689 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 0 | 186,388 | +186,388 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 184,951 | +184,951 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 158,179 | 162,742 | +4,563 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 212,126 | 162,465 | -49,661 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 173,090 | 152,253 | -20,837 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 181,957 | 151,575 | -30,382 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 145,251 | 145,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 106,287 | 138,551 | +32,264 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 222,987 | 137,841 | -85,146 | 0.02 | 0.02 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 306,069 | 136,889 | -169,180 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 80,562 | 129,422 | +48,860 | 0.02 | 0.06 | +0.04 | buy |
| Savant Capital, LLC | 168,447 | 120,374 | -48,073 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 279,212 | 120,272 | -158,940 | 0.03 | 0.02 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 109,787 | 120,191 | +10,404 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 99,056 | 118,256 | +19,200 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 112,316 | 112,316 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 84,980 | 101,540 | +16,560 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 104,257 | 98,290 | -5,967 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 101,057 | 97,947 | -3,110 | 0.05 | 0.03 | -0.01 | sell |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NEOS Investment Management LLC | 97,150 | 93,465 | -3,685 | 0.00 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 97,150 | 93,465 | -3,685 | 0.09 | 0.04 | -0.05 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 166,668 | 87,418 | -79,250 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 92,528 | 82,425 | -10,103 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 81,384 | +81,384 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 72,618 | 79,873 | +7,255 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 76,446 | +76,446 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 82,363 | 70,029 | -12,334 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 56,993 | 67,928 | +10,935 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 75,117 | 63,215 | -11,902 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 61,629 | +61,629 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 68,615 | 61,164 | -7,451 | 0.00 | 0.00 | +0.00 | sell |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allspring Global Investments Holdings, LLC | 60,331 | 59,743 | -588 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 55,174 | 56,454 | +1,280 | 0.00 | 0.00 | +0.00 | buy |
| Intellectus Partners, LLC | 61,425 | 56,425 | -5,000 | 0.05 | 0.06 | +0.01 | sell |
| Dynamic Technology Lab Private Ltd | 16,935 | 54,153 | +37,218 | 0.01 | 0.05 | +0.04 | buy |
| Private Capital Advisors, Inc. | 441,739 | 53,648 | -388,091 | 0.19 | 0.03 | -0.16 | sell |
| PDT Partners, LLC | 53,637 | 53,637 | 0 | 0.01 | 0.02 | +0.01 | hold |
| EntryPoint Capital, LLC | 46,959 | 50,917 | +3,958 | 0.08 | 0.10 | +0.02 | buy |
| MAYPORT, LLC | 0 | 49,681 | +49,681 | 0.00 | 0.06 | +0.06 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,697 | 47,621 | +18,924 | 0.00 | 0.00 | +0.00 | buy |