| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,365,805 | 3,970,045 | +1,604,240 | 0.54 | 1.09 | +0.56 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 335,071 | 1,684,299 | +1,349,228 | 0.02 | 0.09 | +0.08 | buy |
| Bellevue Group AG | 4,885,000 | 5,936,082 | +1,051,082 | 0.66 | 1.00 | +0.34 | buy |
| Casdin Capital, LLC | 6,923,574 | 7,387,943 | +464,369 | 6.44 | 7.98 | +1.54 | buy |
| Finepoint Capital LP | 870,870 | 1,317,870 | +447,000 | 3.65 | 4.58 | +0.93 | buy |
| Rhenman & Partners Asset Management AB | 190,000 | 390,000 | +200,000 | 0.17 | 0.43 | +0.26 | buy |
| ArrowMark Colorado Holdings LLC | 3,810,579 | 3,914,246 | +103,667 | 0.39 | 0.48 | +0.09 | buy |
| PDT Partners, LLC | 140,849 | 194,889 | +54,040 | 0.15 | 0.24 | +0.09 | buy |
| ALGERT GLOBAL LLC | 200,823 | 232,141 | +31,318 | 0.08 | 0.10 | 0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 29,366 | 46,696 | +17,330 | 0.01 | 0.01 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 146,846 | 133,733 | +13,113 | 0.03 | 0.11 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 3,135 | 14,257 | +11,122 | 0.01 | 0.03 | +0.02 | buy |
| PROFUND ADVISORS LLC | 63,931 | 54,029 | +9,902 | 0.03 | 0.03 | 0.00 | sell |
| Dynamic Technology Lab Private Ltd | 14,638 | 20,763 | +6,125 | 0.01 | 0.02 | +0.01 | buy |
| Corton Capital Inc. | 39,402 | 42,786 | +3,384 | 0.17 | 0.15 | -0.02 | buy |
| VIRTUS ADVISERS, LLC | 8,272 | 9,295 | +1,023 | 0.04 | 0.06 | +0.02 | buy |
| CONGRESS ASSET MANAGEMENT CO | 146,434 | 146,974 | +540 | 0.01 | 0.01 | +0.00 | buy |
| Intellectus Partners, LLC | 50,560 | 49,860 | -700 | 0.13 | 0.16 | +0.02 | sell |
| E Fund Management Co., Ltd. | 19,403 | 17,486 | -1,917 | 0.01 | 0.01 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 41,192 | 38,064 | -3,128 | 0.07 | 0.08 | +0.01 | sell |
| BAILLIE GIFFORD & CO | 394,450 | 373,596 | -20,854 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,608,946 | 8,581,167 | -27,779 | 0.01 | 0.01 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 497,490 | 467,966 | -29,524 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 377,745 | 327,548 | -50,197 | 0.02 | 0.02 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 132,210 | 68,606 | -63,604 | 0.02 | 0.01 | -0.01 | sell |
| Integral Health Asset Management, LLC | 800,000 | 600,000 | -200,000 | 0.95 | 0.95 | -0.00 | sell |
| Candriam S.C.A. | 971,070 | 721,070 | -250,000 | 0.06 | 0.05 | -0.00 | sell |
| MPM BioImpact LLC | 1,352,133 | 832,017 | -520,116 | 3.04 | 2.14 | -0.89 | sell |
| T. Rowe Price Investment Management, Inc. | 2,263,360 | 814,814 | -1,448,546 | 0.01 | 0.01 | -0.01 | sell |