| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,365,805 | 3,970,045 | +1,604,240 | 0.54 | 1.09 | +0.56 | buy |
| NORGES BANK | 1,506,828 | 3,068,973 | +1,562,145 | 0.00 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 335,071 | 1,684,299 | +1,349,228 | 0.02 | 0.09 | +0.08 | buy |
| Bellevue Group AG | 4,885,000 | 5,936,082 | +1,051,082 | 0.66 | 1.00 | +0.34 | buy |
| JPMORGAN CHASE & CO | 5,136,484 | 6,065,595 | +929,111 | 0.01 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 6,923,574 | 7,387,943 | +464,369 | 6.49 | 8.02 | +1.53 | buy |
| Finepoint Capital LP | 870,870 | 1,317,870 | +447,000 | 3.65 | 5.02 | +1.37 | buy |
| AMERIPRISE FINANCIAL INC | 95,216 | 459,543 | +364,327 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,017,668 | 1,359,155 | +341,487 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.66 | +0.66 | buy |
| Rhenman & Partners Asset Management AB | 190,000 | 390,000 | +200,000 | 0.17 | 0.43 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 144,700 | 323,700 | +179,000 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,805 | 877,813 | +163,008 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 60,959 | 186,299 | +125,340 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,970,988 | 2,081,510 | +110,522 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,133 | 114,488 | +108,355 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 3,810,579 | 3,914,246 | +103,667 | 0.39 | 0.48 | +0.09 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 98,413 | +98,413 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 10,552,362 | 10,650,387 | +98,025 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 891,605 | 983,387 | +91,782 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 82,761 | +82,761 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 143,722 | 226,312 | +82,590 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 215,469 | 294,785 | +79,316 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 657,541 | 728,704 | +71,163 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 57,347 | +57,347 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 140,849 | 194,889 | +54,040 | 0.15 | 0.24 | +0.09 | buy |
| SG Americas Securities, LLC | 38,414 | 91,973 | +53,559 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 264,354 | 312,190 | +47,836 | 0.00 | 0.00 | +0.00 | buy |
| Pennant Investors, LP | 0 | 42,400 | +42,400 | 0.00 | 0.14 | +0.14 | buy |
| Qube Research & Technologies Ltd | 0 | 34,962 | +34,962 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 32,025 | +32,025 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 200,823 | 232,141 | +31,318 | 0.08 | 0.10 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 0 | 29,911 | +29,911 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 29,669 | +29,669 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 39,202 | 66,336 | +27,134 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 305,200 | 329,600 | +24,400 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 801,358 | 824,350 | +22,992 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 22,110 | +22,110 | 0.00 | 0.02 | +0.02 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 29,366 | 46,696 | +17,330 | 0.01 | 0.01 | +0.01 | buy |
| Gotham Asset Management, LLC | 0 | 16,135 | +16,135 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,264 | 17,400 | +15,136 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 14,314 | +14,314 | 0.00 | 0.05 | +0.05 | buy |
| ROYAL BANK OF CANADA | 15,158 | 27,797 | +12,639 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 12,191 | +12,191 | 0.00 | 0.03 | +0.03 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 89,102 | 101,161 | +12,059 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 85,388 | 97,386 | +11,998 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,501 | +11,501 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 11,467 | +11,467 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 3,135 | 14,257 | +11,122 | 0.01 | 0.03 | +0.02 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 68,937 | +8,937 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 46,013 | 54,285 | +8,272 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 38,900 | 46,850 | +7,950 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 7,775 | +7,775 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 0 | 7,484 | +7,484 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 14,638 | 20,763 | +6,125 | 0.01 | 0.02 | +0.01 | buy |
| HSBC HOLDINGS PLC | 15,017 | 19,520 | +4,503 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 400,673 | 404,916 | +4,243 | 0.01 | 0.01 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,875 | +3,875 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 11,168 | 14,962 | +3,794 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 39,402 | 42,786 | +3,384 | 0.17 | 0.15 | -0.02 | buy |
| ProShare Advisors LLC | 19,713 | 22,820 | +3,107 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 12,916 | 15,321 | +2,405 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,828 | +1,828 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 27,900 | 29,500 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 35,551 | 36,678 | +1,127 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 8,272 | 9,295 | +1,023 | 0.04 | 0.06 | +0.02 | buy |
| Smithfield Trust Co | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 146,434 | 146,974 | +540 | 0.01 | 0.01 | +0.00 | buy |
| C M BIDWELL & ASSOCIATES LTD | 0 | 396 | +396 | 0.00 | 0.00 | +0.00 | buy |
| ADIRONDACK TRUST CO | 0 | 344 | +344 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 420 | 647 | +227 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 87 | +87 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 8 | 12 | +4 | 0.00 | 0.00 | 0.00 | buy |
| BOSTON FAMILY OFFICE LLC | 12,397 | 12,397 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CANADA LIFE ASSURANCE Co | 8,624 | 8,624 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BESSEMER GROUP INC | 584,463 | 584,463 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 8,970 | 8,970 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 23,088 | 23,088 | 0 | 0.04 | 0.04 | +0.01 | hold |
| BRANDYWINE MANAGERS, LLC | 31,807 | 31,807 | 0 | 0.45 | 0.38 | -0.07 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,089 | 11,089 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOURVEST PARTNERS LLC | 296,402 | 296,402 | 0 | 0.85 | 1.09 | +0.25 | hold |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.06 | 0.15 | +0.09 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,165 | 19,165 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blackstone Inc. | 35,618 | 35,618 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 486 | 486 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 46,053 | 46,053 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 7,900 | 7,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Rock Springs Capital Management LP | 673,966 | 673,966 | 0 | 0.15 | 0.18 | +0.03 | hold |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.85 | 0.80 | -0.05 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 1.93 | 2.73 | +0.80 | hold |
| Your Advocates Ltd., LLP | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 250,000 | 250,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Erste Asset Management GmbH | 23,100 | 23,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIDUCIARY TRUST CO | 27,971 | 27,971 | 0 | 0.00 | 0.01 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 5,222 | 5,222 | 0 | 0.00 | 0.00 | +0.00 | hold |