| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 3,568,058 | 8,068,058 | +4,500,000 | 1.80 | 2.20 | +0.39 | buy |
| Candriam S.C.A. | 703,429 | 1,729,199 | +1,025,770 | 0.03 | 0.04 | +0.01 | buy |
| Exome Asset Management LLC | 414,629 | 1,083,487 | +668,858 | 1.98 | 3.36 | +1.37 | buy |
| Finepoint Capital LP | 1,626,146 | 2,175,646 | +549,500 | 0.84 | 0.55 | -0.29 | buy |
| ALGERT GLOBAL LLC | 513,277 | 994,923 | +481,646 | 0.10 | 0.10 | 0.00 | buy |
| MPM BioImpact LLC | 2,033,041 | 2,268,825 | +235,784 | 2.16 | 1.33 | -0.83 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 112,048 | 330,699 | +218,651 | 0.06 | 0.11 | 0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 109,912 | 297,165 | +187,253 | 0.06 | 0.10 | +0.04 | buy |
| Rafferty Asset Management, LLC | 180,030 | 249,561 | +69,531 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 39,584 | 86,641 | +47,057 | 0.03 | 0.04 | +0.01 | buy |
| Mesirow Financial Investment Management, Inc. | 14,536 | 32,916 | +18,380 | 0.00 | 0.00 | +0.00 | buy |
| CONGRESS ASSET MANAGEMENT CO | 146,424 | 157,485 | +11,061 | 0.01 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 25,751 | 35,491 | +9,740 | 0.02 | 0.01 | -0.01 | buy |
| NEOS Investment Management LLC | 58,290 | 64,655 | +6,365 | 0.01 | 0.01 | -0.01 | buy |
| E Fund Management Co., Ltd. | 11,550 | 17,654 | +6,104 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 11,781 | 14,873 | +3,092 | 0.04 | 0.03 | -0.01 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 77,671 | 80,371 | +2,700 | 0.01 | 0.01 | -0.00 | buy |
| Bellevue Group AG | 7,377,184 | 7,377,292 | +108 | 0.85 | 0.59 | -0.26 | buy |
| Ikarian Capital, LLC | 693,350 | 693,308 | -42 | 0.68 | 0.39 | -0.30 | sell |
| BESSEMER GROUP INC | 584,633 | 584,463 | -170 | 0.01 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 26,368 | 22,325 | -4,043 | 0.11 | 0.04 | -0.07 | sell |
| TrueMark Investments, LLC | 60,004 | 55,400 | -4,604 | 0.14 | 0.07 | -0.06 | sell |
| Intellectus Partners, LLC | 67,675 | 61,425 | -6,250 | 0.12 | 0.06 | -0.07 | sell |
| SHERBROOKE PARK ADVISERS LLC | 39,491 | 28,959 | -10,532 | 0.06 | 0.04 | -0.03 | sell |
| PDT Partners, LLC | 127,272 | 108,599 | -18,673 | 0.08 | 0.04 | -0.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,650,000 | 1,400,000 | -250,000 | 0.02 | 0.01 | -0.01 | sell |
| Casdin Capital, LLC | 9,251,108 | 8,948,574 | -302,534 | 4.37 | 2.45 | -1.91 | sell |
| EcoR1 Capital, LLC | 2,500,000 | 641,426 | -1,858,574 | 0.61 | 0.10 | -0.51 | sell |