| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 0 | 1,903,245 | +1,903,245 | 0.00 | 0.29 | +0.29 | buy |
| Casdin Capital, LLC | 11,341,381 | 13,003,574 | +1,662,193 | 4.94 | 6.83 | +1.90 | buy |
| TCG Crossover Management, LLC | 1,810,351 | 3,220,186 | +1,409,835 | 0.46 | 0.90 | +0.44 | buy |
| STATE STREET CORP | 5,065,990 | 6,426,111 | +1,360,121 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 1,141,880 | +1,141,880 | 0.00 | 0.11 | +0.11 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,174,971 | 2,099,912 | +924,941 | 0.01 | 0.03 | +0.02 | buy |
| Nextech Invest, Ltd. | 3,846,409 | 4,701,506 | +855,097 | 3.06 | 3.85 | +0.79 | buy |
| NORGES BANK | 0 | 837,417 | +837,417 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 560,298 | +560,298 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,137,681 | 1,645,403 | +507,722 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 361,190 | 865,481 | +504,291 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 500,000 | +500,000 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 472,045 | +472,045 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,095,635 | 1,560,265 | +464,630 | 0.01 | 0.02 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 451,500 | +451,500 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 398,167 | +398,167 | 0.00 | 0.49 | +0.49 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 389,563 | +389,563 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,054,586 | 3,409,363 | +354,777 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 240,459 | 545,079 | +304,620 | 0.31 | 1.19 | +0.88 | buy |
| VANGUARD GROUP INC | 9,395,744 | 9,691,445 | +295,701 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,764,096 | 2,018,464 | +254,368 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 31,945 | 220,949 | +189,004 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,124,300 | 1,289,800 | +165,500 | 0.01 | 0.02 | +0.01 | buy |
| XTX Topco Ltd | 0 | 157,406 | +157,406 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 744,044 | 896,909 | +152,865 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 152,253 | 296,017 | +143,764 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 114,143 | +114,143 | 0.00 | 0.00 | +0.00 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 0 | 104,953 | +104,953 | 0.00 | 0.05 | +0.05 | buy |
| Squarepoint Ops LLC | 0 | 94,210 | +94,210 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,889 | 222,929 | +86,040 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 82,559 | +82,559 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 78,368 | +78,368 | 0.00 | 0.01 | +0.01 | buy |
| Jain Global LLC | 0 | 66,587 | +66,587 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 118,256 | 181,988 | +63,732 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 61,853 | +61,853 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 60,203 | +60,203 | 0.00 | 0.08 | +0.08 | buy |
| ALPS ADVISORS INC | 82,425 | 142,321 | +59,896 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 101,540 | 157,892 | +56,352 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 214,823 | 259,411 | +44,588 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 151,575 | 193,756 | +42,181 | 0.00 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 42,000 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 39,447 | +39,447 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 33,700 | 72,586 | +38,886 | 0.01 | 0.02 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 393,704 | 432,493 | +38,789 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 220,000 | 250,000 | +30,000 | 0.02 | 0.03 | +0.01 | buy |
| Blueshift Asset Management, LLC | 0 | 26,814 | +26,814 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,111,331 | 1,136,702 | +25,371 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 23,126 | +23,126 | 0.00 | 0.01 | +0.01 | buy |
| Callan Family Office, LLC | 0 | 20,531 | +20,531 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 81,384 | 101,160 | +19,776 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 93,465 | 113,230 | +19,765 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 93,465 | 111,555 | +18,090 | 0.04 | 0.07 | +0.03 | buy |
| Focus Partners Wealth | 0 | 17,333 | +17,333 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 11,669 | 28,952 | +17,283 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 14,314 | 30,930 | +16,616 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 29,399 | 45,799 | +16,400 | 0.00 | 0.00 | +0.00 | buy |
| AssuredPartners Investment Advisors, LLC | 0 | 16,123 | +16,123 | 0.00 | 0.02 | +0.02 | buy |
| WINTON GROUP Ltd | 0 | 16,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 15,052 | +15,052 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 162,465 | 177,486 | +15,021 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 38,709 | 53,201 | +14,492 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 63,215 | 77,536 | +14,321 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 13,639 | +13,639 | 0.00 | 0.03 | +0.03 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 12,900 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 12,551 | +12,551 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 0 | 12,502 | +12,502 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 288,450 | 300,464 | +12,014 | 0.00 | 0.00 | +0.00 | buy |
| Duncan Williams Asset Management, LLC | 0 | 11,763 | +11,763 | 0.00 | 0.02 | +0.02 | buy |
| CAPTRUST FINANCIAL ADVISORS | 25,228 | 35,566 | +10,338 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 479,056 | 489,137 | +10,081 | 0.19 | 0.23 | +0.04 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,621 | 57,234 | +9,613 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 76,446 | 84,163 | +7,717 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,244 | 209,848 | +7,604 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 371,578 | 378,703 | +7,125 | 0.00 | 0.00 | +0.00 | buy |
| Plante Moran Financial Advisors, LLC | 2,000 | 8,764 | +6,764 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 70,029 | 76,679 | +6,650 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 79,873 | 85,836 | +5,963 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 59,743 | 65,447 | +5,704 | 0.00 | 0.00 | +0.00 | buy |
| Private Capital Advisors, Inc. | 53,648 | 59,311 | +5,663 | 0.03 | 0.05 | +0.02 | buy |
| CONGRESS ASSET MANAGEMENT CO | 408,842 | 414,167 | +5,325 | 0.01 | 0.02 | +0.01 | buy |
| Swiss National Bank | 232,700 | 238,000 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 12,373 | 17,277 | +4,904 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 28,776 | 33,391 | +4,615 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 120,191 | 123,994 | +3,803 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 1,139 | 4,426 | +3,287 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 11,175 | 12,984 | +1,809 | 0.02 | 0.03 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,665 | 8,422 | +1,757 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 8,100 | 8,900 | +800 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 680 | +680 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 10,336 | 11,002 | +666 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 3,530 | 4,140 | +610 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 47,147 | 47,644 | +497 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 454 | +454 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1,006 | 1,453 | +447 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 354 | +354 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 4,200 | 4,424 | +224 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,618 | 1,769 | +151 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 32,982 | 33,130 | +148 | 0.05 | 0.08 | +0.03 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 93 | +93 | 0.00 | 0.00 | +0.00 | buy |
| SageView Advisory Group, LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |