| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | 27,904,963 | 0 | 1.10 | 2.36 | +1.26 | hold |
| Commodore Capital LP | 17,000,000 | 17,000,000 | 0 | 4.33 | 9.57 | +5.24 | hold |
| Point72 Asset Management, L.P. | 14,773,676 | 13,859,172 | -914,504 | 0.17 | 0.18 | +0.02 | sell |
| BlackRock, Inc. | 13,759,382 | 13,228,502 | -530,880 | 0.00 | 0.00 | +0.00 | sell |
| Casdin Capital, LLC | 11,341,381 | 13,003,574 | +1,662,193 | 4.94 | 6.83 | +1.90 | buy |
| VANGUARD GROUP INC | 9,395,744 | 9,691,445 | +295,701 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 8,345,610 | 8,345,364 | -246 | 0.91 | 1.34 | +0.43 | sell |
| STATE STREET CORP | 5,065,990 | 6,426,111 | +1,360,121 | 0.00 | 0.00 | +0.00 | buy |
| Nextech Invest, Ltd. | 3,846,409 | 4,701,506 | +855,097 | 3.06 | 3.85 | +0.79 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,054,586 | 3,409,363 | +354,777 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,810,351 | 3,220,186 | +1,409,835 | 0.46 | 0.90 | +0.44 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,482,950 | 2,480,350 | -2,600 | 0.00 | 0.00 | +0.00 | sell |
| MPM BioImpact LLC | 2,282,680 | 2,232,451 | -50,229 | 1.95 | 2.16 | +0.21 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,174,971 | 2,099,912 | +924,941 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 1,764,096 | 2,018,464 | +254,368 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,903,245 | +1,903,245 | 0.00 | 0.29 | +0.29 | buy |
| GOLDMAN SACHS GROUP INC | 1,868,871 | 1,859,634 | -9,237 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,137,681 | 1,645,403 | +507,722 | 0.00 | 0.00 | +0.00 | buy |
| Alphabet Inc. | 1,568,753 | 1,568,753 | 0 | 0.34 | 0.51 | +0.17 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,095,635 | 1,560,265 | +464,630 | 0.01 | 0.02 | +0.01 | buy |
| Kynam Capital Management, LP | 2,887,014 | 1,424,259 | -1,462,755 | 1.12 | 0.78 | -0.34 | sell |
| TWO SIGMA ADVISERS, LP | 1,124,300 | 1,289,800 | +165,500 | 0.01 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,301,036 | 1,163,124 | -137,912 | 0.00 | 0.01 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 1,160,117 | 1,160,117 | 0 | 0.04 | 0.06 | +0.01 | hold |
| ExodusPoint Capital Management, LP | 0 | 1,141,880 | +1,141,880 | 0.00 | 0.11 | +0.11 | buy |
| NORTHERN TRUST CORP | 1,165,434 | 1,138,688 | -26,746 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,111,331 | 1,136,702 | +25,371 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,195,843 | 1,040,949 | -154,894 | 0.00 | 0.00 | +0.00 | sell |
| Foresite Capital Management IV, LLC | 1,000,000 | 1,000,000 | 0 | 2.86 | 3.68 | +0.82 | hold |
| MILLENNIUM MANAGEMENT LLC | 744,044 | 896,909 | +152,865 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 361,190 | 865,481 | +504,291 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 837,417 | +837,417 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,018,115 | 679,115 | -339,000 | 0.03 | 0.02 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,023,110 | 647,899 | -375,211 | 0.01 | 0.01 | +0.00 | sell |
| Allianz Asset Management GmbH | 0 | 560,298 | +560,298 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 240,459 | 545,079 | +304,620 | 0.31 | 1.19 | +0.88 | buy |
| ArrowMark Colorado Holdings LLC | 541,124 | 541,124 | 0 | 0.05 | 0.10 | +0.05 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 500,000 | +500,000 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 479,056 | 489,137 | +10,081 | 0.19 | 0.23 | +0.04 | buy |
| Trexquant Investment LP | 0 | 472,045 | +472,045 | 0.00 | 0.04 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 460,000 | 460,000 | 0 | 0.27 | 0.36 | +0.10 | hold |
| BESSEMER GROUP INC | 584,463 | 457,869 | -126,594 | 0.00 | 0.01 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 501,238 | 456,648 | -44,590 | 0.00 | 0.01 | +0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 451,500 | +451,500 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 393,704 | 432,493 | +38,789 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 462,379 | 425,958 | -36,421 | 0.00 | 0.00 | +0.00 | sell |
| CONGRESS ASSET MANAGEMENT CO | 408,842 | 414,167 | +5,325 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 461,879 | 414,143 | -47,736 | 0.00 | 0.00 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 398,167 | +398,167 | 0.00 | 0.49 | +0.49 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 389,563 | +389,563 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 371,578 | 378,703 | +7,125 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 339,080 | 339,080 | 0 | 0.03 | 0.04 | +0.02 | hold |
| Nuveen, LLC | 288,450 | 300,464 | +12,014 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 152,253 | 296,017 | +143,764 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 214,823 | 259,411 | +44,588 | 0.00 | 0.00 | +0.00 | buy |
| Raiffeisen Bank International AG | 220,000 | 250,000 | +30,000 | 0.02 | 0.03 | +0.01 | buy |
| Swiss National Bank | 232,700 | 238,000 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,889 | 222,929 | +86,040 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 31,945 | 220,949 | +189,004 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 217,592 | 215,741 | -1,851 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 202,244 | 209,848 | +7,604 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 151,575 | 193,756 | +42,181 | 0.00 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 186,388 | 186,388 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 118,256 | 181,988 | +63,732 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 162,465 | 177,486 | +15,021 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 196,459 | 162,285 | -34,174 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 162,742 | 162,222 | -520 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 101,540 | 157,892 | +56,352 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 157,406 | +157,406 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 408,840 | 146,500 | -262,340 | 0.04 | 0.02 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 145,251 | 145,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 82,425 | 142,321 | +59,896 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 120,191 | 123,994 | +3,803 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 138,551 | 117,677 | -20,874 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 114,143 | +114,143 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 93,465 | 113,230 | +19,765 | 0.00 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 93,465 | 111,555 | +18,090 | 0.04 | 0.07 | +0.03 | buy |
| Legal & General Group Plc | 112,316 | 109,208 | -3,108 | 0.00 | 0.00 | +0.00 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 0 | 104,953 | +104,953 | 0.00 | 0.05 | +0.05 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 81,384 | 101,160 | +19,776 | 0.00 | 0.00 | +0.00 | buy |
| ICONIQ Capital, LLC | 94,697 | 94,697 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Squarepoint Ops LLC | 0 | 94,210 | +94,210 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 187,821 | 87,037 | -100,784 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 79,873 | 85,836 | +5,963 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 76,446 | 84,163 | +7,717 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 82,559 | +82,559 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 78,368 | +78,368 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 63,215 | 77,536 | +14,321 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 70,029 | 76,679 | +6,650 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 184,951 | 76,476 | -108,475 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 33,700 | 72,586 | +38,886 | 0.01 | 0.02 | +0.01 | buy |
| CWM, LLC | 67,928 | 67,603 | -325 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 0 | 66,587 | +66,587 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 59,743 | 65,447 | +5,704 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 61,853 | +61,853 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 60,203 | +60,203 | 0.00 | 0.08 | +0.08 | buy |
| DekaBank Deutsche Girozentrale | 60,000 | 60,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Private Capital Advisors, Inc. | 53,648 | 59,311 | +5,663 | 0.03 | 0.05 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 47,621 | 57,234 | +9,613 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 56,454 | 56,454 | 0 | 0.00 | 0.00 | +0.00 | hold |